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Experimental evidences that P21 protein controls Trypanosoma cruzi replication and modulates the pathogenesis of infection
Teixeira, Thaise L; Castilhos, Patrícia; Rodrigues, Cassiano C; Silva, Aline A. da; Brígido, Rebecca TS; Teixeira, Samuel C; Borges, Bruna C; Santos, Marlus A. Dos; Martins, Flávia A; Santos, Paulo César F; Servato, João Paulo S; Silva, Marcelo Santos da; Silva, M.J.B. da; Elias, Maria Carolina; Silva, Claudio V. da.
Afiliación
  • Castilhos, Patrícia; Instituto Butantan. Laboratório Especial de Ciclo Celular.
  • Rodrigues, Cassiano C; Instituto Butantan. Laboratório Especial de Ciclo Celular.
Microb pathog ; 135: 103618, 2019.
Article en En | SES-SP, SESSP-IBPROD, SES-SP | ID: but-ib16129
Biblioteca responsable: BR78.1
Ubicación: BR78.1
ABSTRACT
P21 is a protein secreted by Trypanosoma cruzi (T. cruzi). Previous studies have shown a spectrum of biological activities performed by P21 such as induction of phagocytosis, leukocyte chemotaxis and inhibition of angiogenesis. However, the activity of P21 in T. cruzi infection remains unknown. Here, we reported the role of P21 in mice harboring late T. cruzi infection. Treatment with recombinant P21 protein (rP21) reduced parasite load and angiogenesis, and induced fibrosis in the cardiac tissue of infected mice. In addition, rP21 reduced the growth of epimastigotes, inhibited intracellular replication of amastigotes and modulated the parasite cell cycle. Our data suggest that P21 controls parasite replication in the host, supporting the survival of both parasite and host.
Texto completo: 1 Colección: 06-national / BR Banco de datos: SES-SP / SESSP-IBPROD Idioma: En Revista: Microb pathog Año: 2019 Tipo del documento: Article
Texto completo: 1 Colección: 06-national / BR Banco de datos: SES-SP / SESSP-IBPROD Idioma: En Revista: Microb pathog Año: 2019 Tipo del documento: Article