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Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
Libri, Vincenzo; Yandim, Cihangir; Athanasopoulos, Stavros; Loyse, Naomi; Natisvili, Theona; Law, Pui Pik; Chan, Ping Kei; Mohammad, Tariq; Mauri, Marta; Tam, Kin Tung; Leiper, James; Piper, Sophie; Ramesh, Aravind; Parkinson, Michael H; Huson, Les; Giunti, Paola; Festenstein, Richard.
Afiliación
  • Libri V; Leonard Wolfson Experimental Neurology Centre, University College London, London, UK; National Institute for Health Research Wellcome Trust Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, UK.
  • Yandim C; Gene Control Mechanisms and Disease Group, Department of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
  • Athanasopoulos S; National Institute for Health Research Wellcome Trust Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, UK.
  • Loyse N; National Institute for Health Research Wellcome Trust Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, UK.
  • Natisvili T; Gene Control Mechanisms and Disease Group, Department of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
  • Law PP; Gene Control Mechanisms and Disease Group, Department of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
  • Chan PK; Gene Control Mechanisms and Disease Group, Department of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
  • Mohammad T; National Institute for Health Research Wellcome Trust Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, UK.
  • Mauri M; Max Delbrück Centre for Molecular Medicine, Berlin, Germany.
  • Tam KT; School of Biological Sciences, University of Hong Kong, Hong Kong, China.
  • Leiper J; Nitric Oxide Signalling Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
  • Piper S; Nitric Oxide Signalling Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
  • Ramesh A; Intensive Care Department, Christchurch Hospital, Christchurch, New Zealand.
  • Parkinson MH; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
  • Huson L; National Institute for Health Research Wellcome Trust Imperial Clinical Research Facility, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, UK.
  • Giunti P; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
  • Festenstein R; Gene Control Mechanisms and Disease Group, Department of Medicine and MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK. Electronic address: r.festenstein@imperial.ac.uk.
Lancet ; 384(9942): 504-13, 2014 Aug 09.
Article en En | MEDLINE | ID: mdl-24794816
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complejo Vitamínico B / Ataxia de Friedreich / Niacinamida / Proteínas de Unión a Hierro Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Lancet Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complejo Vitamínico B / Ataxia de Friedreich / Niacinamida / Proteínas de Unión a Hierro Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Lancet Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido