Targeting of the P2X7 receptor in pancreatic cancer and stellate cells.

Giannuzzo, Andrea; Saccomano, Mara; Napp, Joanna; Ellegaard, Maria; Alves, Frauke; Novak, Ivana

Giannuzzo, Andrea; Saccomano, Mara; Napp, Joanna; Ellegaard, Maria; Alves, Frauke; Novak, Ivana.

Afiliación

Giannuzzo A; Section for Cell Biology and Physiology, August Krogh Building, Department of Biology, University of Copenhagen, Denmark.
Saccomano M; Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Hermann-Rein-Straße 3, Göttingen, D-37075, Germany.
Napp J; Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, Hermann-Rein-Straße 3, Göttingen, D-37075, Germany.
Ellegaard M; Department of Haematology and Medical Oncology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen, D-37075, Germany.
Alves F; Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen, D-37075, Germany.
Novak I; Departments of Clinical Biochemistry and Endocrinology, Rigshospitalet, Research Center for Ageing and Osteoporosis, Glostrup, Denmark.

Int J Cancer ; 139(11): 2540-52, 2016 12 01.

Article en En | MEDLINE | ID: mdl-27513892

Asunto(s)

Adamantano/análogos & derivados; Aminoquinolinas/farmacología; Carcinoma Ductal Pancreático/tratamiento farmacológico; Carcinoma Ductal Pancreático/metabolismo; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/metabolismo; Receptores Purinérgicos P2X7/biosíntesis; Adamantano/farmacología; Animales; Carcinoma Ductal Pancreático/patología; Procesos de Crecimiento Celular/efectos de los fármacos; Línea Celular Tumoral; Xenoinjertos; Humanos; Mediciones Luminiscentes; Masculino; Ratones; Ratones Endogámicos BALB C; Terapia Molecular Dirigida; Neoplasias Pancreáticas/patología; Células Estrelladas Pancreáticas/efectos de los fármacos; Células Estrelladas Pancreáticas/metabolismo; Células Estrelladas Pancreáticas/patología; Receptores Purinérgicos P2X7/metabolismo

Palabras clave

AZ10606120; P2X7; PDAC; fibrosis; stellate cells

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adamantano / Carcinoma Ductal Pancreático / Receptores Purinérgicos P2X7 / Aminoquinolinas Límite: Animals / Humans / Male Idioma: En Revista: Int J Cancer Año: 2016 Tipo del documento: Article País de afiliación: Dinamarca

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