An intersubunit electrostatic interaction in the GABA<sub>A</sub> receptor facilitates its responses to benzodiazepines.

Pflanz, Natasha C; Daszkowski, Anna W; Cornelison, Garrett L; Trudell, James R; Mihic, S John

An intersubunit electrostatic interaction in the GABA_A receptor facilitates its responses to benzodiazepines.

Pflanz, Natasha C; Daszkowski, Anna W; Cornelison, Garrett L; Trudell, James R; Mihic, S John.

Afiliación

Pflanz NC; Department of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712.
Daszkowski AW; Department of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712.
Cornelison GL; Department of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712.
Trudell JR; Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305.
Mihic SJ; Department of Neuroscience, Division of Pharmacology and Toxicology, Waggoner Center for Alcohol and Addiction Research, Institutes for Neuroscience and Cell and Molecular Biology, University of Texas, Austin, Texas 78712. Electronic address: mihic@austin.utexas.edu.

J Biol Chem ; 293(21): 8264-8274, 2018 05 25.

Article en En | MEDLINE | ID: mdl-29622679

Asunto(s)

Benzodiazepinas/farmacología; Moduladores del GABA/farmacología; Activación del Canal Iónico; Receptores de GABA-A/metabolismo; Electricidad Estática; Sustitución de Aminoácidos; Animales; Cristalografía por Rayos X; Humanos; Conformación Proteica; Subunidades de Proteína; Receptores de GABA-A/química; Receptores de GABA-A/genética; Xenopus laevis

Palabras clave

Cys-loop receptor; GABA receptor; Xenopus; allosteric regulation; benzodiazepines; cysteine-mediated cross-linking; electrophysiology; electrostatics; ionotropic receptor; sedative

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzodiazepinas / Activación del Canal Iónico / Receptores de GABA-A / Moduladores del GABA / Electricidad Estática Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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