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Co-infection with distinct Trypanosoma cruzi strains induces an activated immune response in human monocytes.

Magalhães, Luísa M D; Passos, Lívia S A; Chiari, Egler; Galvão, Lúcia M C; Koh, Carolina C; Rodrigues-Alves, Marina L; Giunchetti, Rodolfo C; Gollob, Kenneth; Dutra, Walderez O.
Parasite Immunol ; 41(11): e12668, 2019 11.
Artículo en Inglés | MEDLINE | ID: mdl-31494949


The aim of the study was to evaluate the immune response triggered by the first contact of human monocytes with two T cruzi strains from distinct discrete typing units (DTUs) IV and V, and whether co-infection with these strains leads to changes in monocyte immune profiles, which could in turn influence the subsequent infection outcome. METHODS AND


We evaluated the influence of in vitro single- and co-infection with AM64 and 3253 strains on immunological characteristics of human monocytes. Single infection of monocytes with AM64 or 3253 induced opposing anti-inflammatory and inflammatory responses, respectively. Co-infection was observed in over 50% of monocytes after 15 hours of culture, but this percentage dropped ten-fold after 72 hours. Co-infection led to high monocyte activation and an increased percentage of both IL-10 and TNF. The decreased percentage of co-infected cells observed after 72 hours was associated with a decreased frequency of TNF-expressing cells.


Our results show that the exacerbated response observed in co-infection with immune-polarizing strains is associated with a decreased frequency of co-infected cells, suggesting that the activated response favours parasite control. These findings may have implications for designing new Chagas disease preventive strategies.