Your browser doesn't support javascript.

BVS del Sindicato Médico del Uruguay

Portal de Búsqueda de la BVS

Home > Búsqueda > ()
XML
Imprimir Exportar

Formato de exportación:

Exportar

Email
Adicionar mas contactos
| |

Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis.

Ruiz-Grosso, Paulo; Cachay, Rodrigo; de la Flor, Adriana; Schwalb, Alvaro; Ugarte-Gil, Cesar.
PLoS One ; 15(1): e0227472, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31923280

BACKGROUND:

Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment.

METHODS:

We systematically reviewed studies that evaluated depressive symptoms (DS) directly or indirectly through psychological distress (PD) and measured negative treatment outcomes of drug-sensitive pulmonary TB, defined as death, loss to follow-up, or non-adherence. Sources included PubMed, Global Health Library, Embase, Scopus and Web of Science from inception to August 2019.

RESULTS:

Of the 2,970 studies initially identified, eight articles were eligible for inclusion and two were used for the primary outcome meta-analysis. We found a strong association between DS and negative TB treatment outcomes (OR = 4.26; CI95%2.33-7.79; I2 = 0%). DS were also associated with loss to follow-up (OR = 8.70; CI95%6.50-11.64; I2 = 0%) and death (OR = 2.85; CI95%1.52-5.36; I2 = 0%). Non-adherence was not associated with DS and PD (OR = 1.34; CI95%0.70-2.72; I2 = 94.36) or PD alone (OR = 0.92; CI95%0.81-1.05; I2 = 0%).

CONCLUSIONS:

DS are associated with the negative TB treatment outcomes of death and loss to follow-up. Considerable heterogeneity exists in the definition of depression and outcomes such as non-adherence across the limited number of studies on this topic.