Endogenous serum testosterone in males after different doses and routes of administration of medroxyprogesterone acetate.
J Reprod Med
; 25(4): 157-60, 1980 Oct.
Article
en En
| MEDLINE
| ID: mdl-7431362
ABSTRACT
PIP: The effects of different doses and routes of administration (both oral and intramuscular) of medroxyprogesterone acetate on endogenous testosterone secretions were studied in healthy male volunteers. There were 3 treatment groups. Serum testosterone levels, measured by radioimmunoassay before, during, and after different doses of medroxyprogesterone acetate, were significantly lowered (P0.05) in these subjects. A tendency to return toward pretreatment values was noted within 3-6 weeks after the last dose of medroxyprogesterone acetate. Testosterone levels were suppressed for the longest period of time through intramuscular administration. No indication of drug-induced toxicity, as judged by vital signs, systemic side effects, standard laboratory evaluations and some special clinical evaluations, was found during treatment or in the period immediately following therapy. No serious or untoward side effects were encountered.
Palabras clave
Androgens; Biology; Clinical Research; Contraception; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents--administraction and dosage; Endocrine System; Family Planning; Hormones; Human Volunteers; Medroxyprogesterone Acetate--administraction and dosage; Men; Physiology; Research Methodology; Testosterone--analysis
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Testosterona
/
Medroxiprogesterona
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Reprod Med
Año:
1980
Tipo del documento:
Article