1.
Bioorg Med Chem Lett
; 14(17): 4585-9, 2004 Sep 06.
Article
in English
| MEDLINE
| ID: mdl-15357997
ABSTRACT
A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).