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1.

Chemical Evolution of Natural Product Structure.

Grigalunas, Michael; Brakmann, Susanne; Waldmann, Herbert.

J Am Chem Soc ; 144(8): 3314-3329, 2022 03 02.

Article in English | MEDLINE | ID: mdl-35188375

2.

Pseudo Natural Products-Chemical Evolution of Natural Product Structure.

Karageorgis, George; Foley, Daniel J; Laraia, Luca; Brakmann, Susanne; Waldmann, Herbert.

Angew Chem Int Ed Engl ; 60(29): 15705-15723, 2021 07 12.

Article in English | MEDLINE | ID: mdl-33644925

3.

Optical Control of Transcription: Genetically Encoded Photoswitchable Variants of T7 RNA Polymerase.

Seifert, Swantje; Ehrt, Christiane; Lückfeldt, Lena; Lubeck, Melissa; Schramm, Frederik; Brakmann, Susanne.

Chembiochem ; 20(22): 2813-2817, 2019 11 18.

Article in English | MEDLINE | ID: mdl-31192518

4.

The double mutation L109M and R448M of HIV-1 reverse transcriptase decreases fidelity of DNA synthesis by promoting mismatch elongation.

Heyn, Bianca; Pogodalla, Nicole; Brakmann, Susanne.

Biol Chem ; 396(12): 1315-23, 2015 Dec.

Article in English | MEDLINE | ID: mdl-26351907

5.

Exonucleolytic degradation of high-density labeled DNA studied by fluorescence correlation spectroscopy.

Ehrlich, Nicky; Anhalt, Katrin; Paulsen, Hauke; Brakmann, Susanne; Hübner, Christian G.

Analyst ; 137(5): 1160-7, 2012 Mar 07.

Article in English | MEDLINE | ID: mdl-22268065

6.

Directed evolution of an error-prone T7 DNA polymerase that attenuates viral replication.

Söte, Sandra; Kleine, Stefan; Schlicke, Marina; Brakmann, Susanne.

Chembiochem ; 12(10): 1551-8, 2011 Jul 04.

Article in English | MEDLINE | ID: mdl-21626635

7.

Single-molecule analysis: A ribosome in action.

Brakmann, Susanne.

Nature ; 464(7291): 987-8, 2010 Apr 15.

Article in English | MEDLINE | ID: mdl-20393548

8.

Activity-based selection of HIV-1 reverse transcriptase variants with decreased polymerization fidelity.

Stumpp, Sascha N; Heyn, Bianca; Brakmann, Susanne.

Biol Chem ; 391(6): 665-74, 2010 Jun.

Article in English | MEDLINE | ID: mdl-20370322

9.

Exonuclease III action on microarrays: observation of DNA degradation by fluorescence correlation spectroscopy.

Ehrlich, Nicky; Anhalt, Katrin; Hübner, Christian; Brakmann, Susanne.

Anal Biochem ; 399(2): 251-6, 2010 Apr 15.

Article in English | MEDLINE | ID: mdl-20004637

10.

Sequencing single DNA molecules in real time.

Ibach, Jenny; Brakmann, Susanne.

Angew Chem Int Ed Engl ; 48(26): 4683-5, 2009.

Article in English | MEDLINE | ID: mdl-19415712

11.

LOV Domains in the Design of Photoresponsive Enzymes.

Seifert, Swantje; Brakmann, Susanne.

ACS Chem Biol ; 13(8): 1914-1920, 2018 08 17.

Article in English | MEDLINE | ID: mdl-29905467

12.

Optimal enzymes for single-molecule sequencing.

Brakmann, Susanne.

Curr Pharm Biotechnol ; 5(1): 119-26, 2004 Feb.

Article in English | MEDLINE | ID: mdl-14965214

13.

High-density labeling of DNA for single molecule sequencing.

Brakmann, Susanne.

Methods Mol Biol ; 283: 137-44, 2004.

Article in English | MEDLINE | ID: mdl-15197307

14.

Identification of a T7 RNA polymerase variant that permits the enzymatic synthesis of fully 2'-O-methyl-modified RNA.

Ibach, Jenny; Dietrich, Laura; Koopmans, Kyra R M; Nöbel, Nico; Skoupi, Marc; Brakmann, Susanne.

J Biotechnol ; 167(3): 287-95, 2013 Sep 10.

Article in English | MEDLINE | ID: mdl-23871655

15.

DNA-based barcodes, nanoparticles, and nanostructures for the ultrasensitive detection and quantification of proteins.

Brakmann, Susanne.

Angew Chem Int Ed Engl ; 43(43): 5730-4, 2004 Nov 05.

Article in English | MEDLINE | ID: mdl-15523731

16.

A further step towards single-molecule sequencing: Escherichia coli exonuclease III degrades DNA that is fluorescently labeled at each base pair.

Brakmann, Susanne; Löbermann, Sylvia.

Angew Chem Int Ed Engl ; 41(17): 3215-7, 2002 Sep 02.

Article in English | MEDLINE | ID: mdl-12207394

17.

High-Density Labeling of DNA: Preparation and Characterization of the Target Material for Single-Molecule Sequencing The authors are grateful to Dr. Dmitri Czerny of the Max Planck Institute for Biophysical Chemistry, Göttingen, for generating the electron micrograph. Our work was supported by the Max-Planck-Gesellschaft, the BMBF together with Roche Diagnostics (grant no.: 0311003), and the Deutsche Forschungsgemeinschaft (grant no.: Ei 411/1-1).

Brakmann, Susanne; Löbermann, Sylvia.

Angew Chem Int Ed Engl ; 40(8): 1427-1429, 2001 Apr 17.

Article in English | MEDLINE | ID: mdl-11317292

18.

High-Density Labeling of DNA: Preparation and Characterization of the Target Material for Single-Molecule Sequencing.

Brakmann, Susanne; Löbermann, Sylvia.

Angew Chem Int Ed Engl ; 40(8): 1427-1429, 2001 Apr 17.

Article in English | MEDLINE | ID: mdl-29712349

19.

Expression and purification of histidine-tagged bacteriophage T7 DNA polymerase.

Schlicke, Marina; Brakmann, Susanne.

Protein Expr Purif ; 39(2): 247-53, 2005 Feb.

Article in English | MEDLINE | ID: mdl-15642476

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Chemical Evolution of Natural Product Structure.

Pseudo Natural Products-Chemical Evolution of Natural Product Structure.

Optical Control of Transcription: Genetically Encoded Photoswitchable Variants of T7 RNA Polymerase.

The double mutation L109M and R448M of HIV-1 reverse transcriptase decreases fidelity of DNA synthesis by promoting mismatch elongation.

Exonucleolytic degradation of high-density labeled DNA studied by fluorescence correlation spectroscopy.

Directed evolution of an error-prone T7 DNA polymerase that attenuates viral replication.

Single-molecule analysis: A ribosome in action.

Activity-based selection of HIV-1 reverse transcriptase variants with decreased polymerization fidelity.

Exonuclease III action on microarrays: observation of DNA degradation by fluorescence correlation spectroscopy.

Sequencing single DNA molecules in real time.

LOV Domains in the Design of Photoresponsive Enzymes.

Optimal enzymes for single-molecule sequencing.

High-density labeling of DNA for single molecule sequencing.

Identification of a T7 RNA polymerase variant that permits the enzymatic synthesis of fully 2'-O-methyl-modified RNA.

DNA-based barcodes, nanoparticles, and nanostructures for the ultrasensitive detection and quantification of proteins.

A further step towards single-molecule sequencing: Escherichia coli exonuclease III degrades DNA that is fluorescently labeled at each base pair.

High-Density Labeling of DNA: Preparation and Characterization of the Target Material for Single-Molecule Sequencing.

Expression and purification of histidine-tagged bacteriophage T7 DNA polymerase.