1.
Org Lett
; 24(1): 85-89, 2022 Jan 14.
Article
in English
| MEDLINE
| ID: mdl-34913706
ABSTRACT
Herein we report ketones as feedstock materials in radical cross-coupling reactions under Ni/photoredox dual catalysis. In this approach, simple condensation first converts ketones into prearomatic intermediates that then act as activated radical sources for cross-coupling with aryl halides. Our strategy enables the direct benzylation/benzoylation of (hetero)arenes under mild reaction conditions with high functional group tolerance.