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1.
CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase.
Nucleic Acids Res
; 51(D1): D1230-D1241, 2023 01 06.
Article
in English
| MEDLINE | ID: mdl-36373660
2.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Article
in English
| MEDLINE | ID: mdl-35065235
3.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Article
in English
| MEDLINE | ID: mdl-27479743
4.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc Natl Acad Sci U S A
; 112(32): E4410-7, 2015 Aug 11.
Article
in English
| MEDLINE | ID: mdl-26216984
5.
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 25(1): 75-82, 2015 Jan 01.
Article
in English
| MEDLINE | ID: mdl-25466195
6.
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 24(24): 5683-5687, 2014 Dec 15.
Article
in English
| MEDLINE | ID: mdl-25467161
7.
Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 24(16): 3764-71, 2014 Aug 15.
Article
in English
| MEDLINE | ID: mdl-25037916
8.
Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 23(20): 5533-9, 2013 Oct 15.
Article
in English
| MEDLINE | ID: mdl-24012183
9.
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 23(11): 3186-94, 2013 Jun 01.
Article
in English
| MEDLINE | ID: mdl-23628333
10.
Clinical Targeted Next-Generation Panel Sequencing Reveals MYC Amplification Is a Poor Prognostic Factor in Osteosarcoma.
JCO Precis Oncol
; 7: e2200334, 2023 03.
Article
in English
| MEDLINE | ID: mdl-36996377
11.
Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer.
Nat Med
; 28(8): 1581-1589, 2022 08.
Article
in English
| MEDLINE | ID: mdl-35739269
12.
Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor.
JCO Precis Oncol
; 52021.
Article
in English
| MEDLINE | ID: mdl-34964003
13.
Ushering in the next generation of precision trials for pediatric cancer.
Science
; 363(6432): 1175-1181, 2019 Mar 15.
Article
in English
| MEDLINE | ID: mdl-30872517
14.
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.
Nat Commun
; 10(1): 137, 2019 01 11.
Article
in English
| MEDLINE | ID: mdl-30635584
15.
Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 10(1): 2527, 2019 Jun 04.
Article
in English
| MEDLINE | ID: mdl-31164653
16.
Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling.
Mol Cell Biol
; 24(10): 4255-66, 2004 May.
Article
in English
| MEDLINE | ID: mdl-15121846
17.
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nat Commun
; 8: 15522, 2017 05 25.
Article
in English
| MEDLINE | ID: mdl-28541300
18.
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 8(1): 103, 2017 07 24.
Article
in English
| MEDLINE | ID: mdl-28740126
19.
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
ACS Med Chem Lett
; 7(10): 896-901, 2016 Oct 13.
Article
in English
| MEDLINE | ID: mdl-27774125
20.
Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.
Cell Rep
; 13(5): 1033-45, 2015 Nov 03.
Article
in English
| MEDLINE | ID: mdl-26565915