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1.

Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.

Castle, Andrew R; Kang, Sang-Gyun; Eskandari-Sedighi, Ghazaleh; Wohlgemuth, Serene; Nguyen, My-Anh; Drucker, Daniel J; Mulvihill, Erin E; Westaway, David.

Proc Natl Acad Sci U S A ; 120(1): e2209815120, 2023 01 03.

Article in English | MEDLINE | ID: mdl-36574660

2.

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He, Shun; Kahles, Florian; Rattik, Sara; Nairz, Manfred; McAlpine, Cameron S; Anzai, Atsushi; Selgrade, Daniel; Fenn, Ashley M; Chan, Christopher T; Mindur, John E; Valet, Colin; Poller, Wolfram C; Halle, Lennard; Rotllan, Noemi; Iwamoto, Yoshiko; Wojtkiewicz, Gregory R; Weissleder, Ralph; Libby, Peter; Fernández-Hernando, Carlos; Drucker, Daniel J; Nahrendorf, Matthias; Swirski, Filip K.

Nature ; 566(7742): 115-119, 2019 02.

Article in English | MEDLINE | ID: mdl-30700910

3.

Treatment of type 2 diabetes with the designer cytokine IC7Fc.

Findeisen, Maria; Allen, Tamara L; Henstridge, Darren C; Kammoun, Helene; Brandon, Amanda E; Baggio, Laurie L; Watt, Kevin I; Pal, Martin; Cron, Lena; Estevez, Emma; Yang, Christine; Kowalski, Greg M; O'Reilly, Liam; Egan, Casey; Sun, Emily; Thai, Le May; Krippner, Guy; Adams, Timothy E; Lee, Robert S; Grötzinger, Joachim; Garbers, Christoph; Risis, Steve; Kraakman, Michael J; Mellet, Natalie A; Sligar, James; Kimber, Erica T; Young, Richard L; Cowley, Michael A; Bruce, Clinton R; Meikle, Peter J; Baldock, Paul A; Gregorevic, Paul; Biden, Trevor J; Cooney, Gregory J; Keating, Damien J; Drucker, Daniel J; Rose-John, Stefan; Febbraio, Mark A.

Nature ; 574(7776): 63-68, 2019 10.

Article in English | MEDLINE | ID: mdl-31554967

4.

Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.

Sourris, Karly C; Ding, Yi; Maxwell, Scott S; Al-Sharea, Annas; Kantharidis, Phillip; Mohan, Muthukumar; Rosado, Carlos J; Penfold, Sally A; Haase, Claus; Xu, Yangsong; Forbes, Josephine M; Crawford, Simon; Ramm, Georg; Harcourt, Brooke E; Jandeleit-Dahm, Karin; Advani, Andrew; Murphy, Andrew J; Timmermann, Daniel B; Karihaloo, Anil; Knudsen, Lotte Bjerre; El-Osta, Assam; Drucker, Daniel J; Cooper, Mark E; Coughlan, Melinda T.

Kidney Int ; 105(1): 132-149, 2024 Jan.

Article in English | MEDLINE | ID: mdl-38069998

5.

The expanding incretin universe: from basic biology to clinical translation.

Drucker, Daniel J; Holst, Jens J.

Diabetologia ; 66(10): 1765-1779, 2023 10.

Article in English | MEDLINE | ID: mdl-36976349

6.

Transforming type 1 diabetes: the next wave of innovation.

Drucker, Daniel J.

Diabetologia ; 64(5): 1059-1065, 2021 05.

Article in English | MEDLINE | ID: mdl-33550440

7.

Glucagon-Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T-Cell Proliferation.

Moschovaki Filippidou, Foteini; Kirsch, Alexander H; Thelen, Matthias; Kétszeri, Máté; Artinger, Katharina; Aringer, Ida; Schabhüttl, Corinna; Mooslechner, Agnes A; Frauscher, Bianca; Pollheimer, Marion; Niedrist, Tobias; Meinitzer, Andreas; Drucker, Daniel J; Pieber, Thomas R; Eller, Philipp; Rosenkranz, Alexander R; Heinemann, Akos; Eller, Kathrin.

Am J Pathol ; 190(2): 400-411, 2020 02.

Article in English | MEDLINE | ID: mdl-31759969

8.

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension.

Helmstädter, Johanna; Frenis, Katie; Filippou, Konstantina; Grill, Alexandra; Dib, Mobin; Kalinovic, Sanela; Pawelke, Franziska; Kus, Kamil; Kröller-Schön, Swenja; Oelze, Matthias; Chlopicki, Stefan; Schuppan, Detlef; Wenzel, Philip; Ruf, Wolfram; Drucker, Daniel J; Münzel, Thomas; Daiber, Andreas; Steven, Sebastian.

Arterioscler Thromb Vasc Biol ; 40(1): 145-158, 2020 01.

Article in English | MEDLINE | ID: mdl-31747801

9.

Body weight homeostat that regulates fat mass independently of leptin in rats and mice.

Jansson, John-Olov; Palsdottir, Vilborg; Hägg, Daniel A; Schéle, Erik; Dickson, Suzanne L; Anesten, Fredrik; Bake, Tina; Montelius, Mikael; Bellman, Jakob; Johansson, Maria E; Cone, Roger D; Drucker, Daniel J; Wu, Jianyao; Aleksic, Biljana; Törnqvist, Anna E; Sjögren, Klara; Gustafsson, Jan-Åke; Windahl, Sara H; Ohlsson, Claes.

Proc Natl Acad Sci U S A ; 115(2): 427-432, 2018 01 09.

Article in English | MEDLINE | ID: mdl-29279372

10.

Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors.

Nauck, Michael A; Meier, Juris J; Cavender, Matthew A; Abd El Aziz, Mirna; Drucker, Daniel J.

Circulation ; 136(9): 849-870, 2017 Aug 29.

Article in English | MEDLINE | ID: mdl-28847797

11.

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Claussnitzer, Melina; Dankel, Simon N; Kim, Kyoung-Han; Quon, Gerald; Meuleman, Wouter; Haugen, Christine; Glunk, Viktoria; Sousa, Isabel S; Beaudry, Jacqueline L; Puviindran, Vijitha; Abdennur, Nezar A; Liu, Jannel; Svensson, Per-Arne; Hsu, Yi-Hsiang; Drucker, Daniel J; Mellgren, Gunnar; Hui, Chi-Chung; Hauner, Hans; Kellis, Manolis.

N Engl J Med ; 373(10): 895-907, 2015 Sep 03.

Article in English | MEDLINE | ID: mdl-26287746

12.

Physiology and pharmacology of the enteroendocrine hormone glucagon-like peptide-2.

Drucker, Daniel J; Yusta, Bernardo.

Annu Rev Physiol ; 76: 561-83, 2014.

Article in English | MEDLINE | ID: mdl-24161075

13.

Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy.

Takashima, Satoru; Fujita, Hiroki; Fujishima, Hiromi; Shimizu, Tatsunori; Sato, Takehiro; Morii, Tsukasa; Tsukiyama, Katsushi; Narita, Takuma; Takahashi, Takamune; Drucker, Daniel J; Seino, Yutaka; Yamada, Yuichiro.

Kidney Int ; 90(4): 783-96, 2016 10.

Article in English | MEDLINE | ID: mdl-27475229

14.

Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

Takai, Shingo; Yasumatsu, Keiko; Inoue, Mayuko; Iwata, Shusuke; Yoshida, Ryusuke; Shigemura, Noriatsu; Yanagawa, Yuchio; Drucker, Daniel J; Margolskee, Robert F; Ninomiya, Yuzo.

FASEB J ; 29(6): 2268-80, 2015 Jun.

Article in English | MEDLINE | ID: mdl-25678625

15.

Cardiovascular actions of incretin-based therapies.

Ussher, John R; Drucker, Daniel J.

Circ Res ; 114(11): 1788-803, 2014 May 23.

Article in English | MEDLINE | ID: mdl-24855202

16.

N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway.

Johswich, Anita; Longuet, Christine; Pawling, Judy; Abdel Rahman, Anas; Ryczko, Michael; Drucker, Daniel J; Dennis, James W.

J Biol Chem ; 289(23): 15927-41, 2014 Jun 06.

Article in English | MEDLINE | ID: mdl-24742675

17.

A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity.

Noyan-Ashraf, Mohammad Hossein; Shikatani, Eric Akihiko; Schuiki, Irmgard; Mukovozov, Ilya; Wu, Jun; Li, Ren-Ke; Volchuk, Allen; Robinson, Lisa Annette; Billia, Filio; Drucker, Daniel J; Husain, Mansoor.

Circulation ; 127(1): 74-85, 2013 Jan 01.

Article in English | MEDLINE | ID: mdl-23186644

18.

The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.

Fujita, Hiroki; Morii, Tsukasa; Fujishima, Hiromi; Sato, Takehiro; Shimizu, Tatsunori; Hosoba, Mihoko; Tsukiyama, Katsushi; Narita, Takuma; Takahashi, Takamune; Drucker, Daniel J; Seino, Yutaka; Yamada, Yuichiro.

Kidney Int ; 85(3): 579-89, 2014 Mar.

Article in English | MEDLINE | ID: mdl-24152968

19.

GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents.

Ye, Jianping; Hao, Zheng; Mumphrey, Michael B; Townsend, R Leigh; Patterson, Laurel M; Stylopoulos, Nicholas; Münzberg, Heike; Morrison, Christopher D; Drucker, Daniel J; Berthoud, Hans-Rudolf.

Am J Physiol Regul Integr Comp Physiol ; 306(5): R352-62, 2014 Mar 01.

Article in English | MEDLINE | ID: mdl-24430883

20.

Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity.