Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics.

To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., sweat), play a critical role, because they can be deployed at a large scale to monitor the individuals' drug transcourse profiles (semi)continuously and longitudinally. To this end, voltammetry-based sensing modalities are suitable, as in principle they can detect and quantify electroactive drugs on the basis of the target's redox signature. However, the target's redox signature in complex biofluid matrices can be confounded by the immediate biofouling effects and distorted/buried by the interfering voltammetric responses of endogenous electroactive species. Here, we devise a wearable voltammetric sensor development strategy-centering on engineering the molecule-surface interactions-to simultaneously mitigate biofouling and create an "undistorted potential window" within which the target drug's voltammetric response is dominant and interference is eliminated. To inform its clinical utility, our strategy was adopted to track the temporal profile of circulating acetaminophen (a widely used analgesic and antipyretic) in saliva and sweat, using a surface-modified boron-doped diamond sensing interface (cross-validated with laboratory-based assays, R2 ∼ 0.94). Through integration of the engineered sensing interface within a custom-developed smartwatch, and augmentation with a dedicated analytical framework (for redox peak extraction), we realized a wearable solution to seamlessly render drug readouts with minute-level temporal resolution. Leveraging this solution, we demonstrated the pharmacokinetic correlation and significance of sweat readings.

[Spatiotemporal variations and attribution analysis of reference evapotranspiration in the Fenwei Plain under climate change]. / æ°”å€™å˜åŒ–èƒŒæ™¯ä¸‹æ±¾æ¸­å¹³åŽŸå‚è€ƒä½œç‰©è’¸æ•£é‡çš„æ—¶ç©ºå˜åŒ–ä¸Žå½’å› åˆ†æž.

Reference crop evapotranspiration (ET0) is a crucial variable for estimating the ecological water demand of vegetation. Under climate change, the trends of ET0 change vary in different regions. The study of spatial and temporal variations in ET0 and attribution analysis at the regional scale is more conducive to the regional agricultural water management and ecological water demand estimation under the changing environment. We analyzed the change trend, spatial distribution and the contribution of meteorological factors to annual ET0 change of the Fenwei Plain during a historical period (1985-2015) and a future period (2030-2060) based on the latest climate data and high-precision grid data from the Sixth International Coupled Model Intercomparison Project (CMIP6). The results showed that the meteorological data from CMIP6 could be used for the prediction of ET0 after bias correction, and that the prediction accuracy of the multi-model ensemble approach (R2 of 82.9%, RMSE of 14.9 mm) was higher than that of a single climate model. ET0 in the Fenwei Plain showed a significant decreasing trend in the historical period, but a non-significant increasing and significant increasing trend in the future period under the SSP245 and SSP585 scenarios, respectively. The vapor pressure deficit had the largest contribution to the ET0 change in both the historical and future periods, and was the primary meteorological factor affecting the ET0 change in the Fenwei Plain under the climate change. Solar radiation and wind speed were important meteorological factors affecting the ET0 change in the historical period, while temperature and wind speed were the important meteorological factors affecting the ET0 change in the future period. The meteorological factors that had great contribution to ET0 change were due to the larger multi-year relative change rates, rather than the high sensitivity of these meteorological factors to ET0. The ET0 of the plain under the SSP245 and SSP585 scenarios increased by 4.2% and 3.1% in the future period, respectively, compared with the historical period. The differences in the spatial distribution of the result were mainly from the eastern and western regions of the plain. Based on the high-precision spatial and temporal distribution of ET0, the spatial and temporal data could be used as a reference for the development of various adaptation for climate change in the Fenwei Plain.

Electric field control of the magnetocaloric effect.

Through strain-mediated magnetoelectric coupling, it is demonstrated that the magnetocaloric effect of a ferromagnetic shape-memory alloy can be controlled by an electric field. Large hysteresis and the limited operating temperature region are effectively overcome by applying an electric field on a laminate comprising a piezoelectric and the alloy. Accordingly, a model for an active magnetic refrigerator with high efficiency is proposed in principle.

Preparation, characterization and photocatalytic properties of CdS nanoparticles dotted on the surface of carbon nanotubes.

Cadmium sulfide (CdS) nanoparticles dotted on the surface of multiwalled carbon nanotubes (MWCNTs) have been synthesized by the polyol method. The as-prepared materials were characterized by x-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, and Brunauer-Emmett-Teller adsorption analysis. The results indicate that CdS nanoparticles with diameter of 5-8 nm are thickly and uniformly coated on the surface of the MWCNTs. The photodegradation of azo dye using these materials was evaluated by the degradation of Brilliant Red X-3B under visible light. The coated nanotubes show higher photocatalytic activity than both CdS alone and a CdS/activated carbon sample; in addition, there is an optimum content of MWCNTs. The presence of MWCNTs can also hamper the photocorrosion of CdS. The mechanism for the enhancement of MWCNTs on the adsorption and photocatalytic property of CdS is investigated for the first time.