ABSTRACT
The development of a malignant soft tissue tumour (malignant fibrous histiocytoma) in a surgical wound is reported. Although rare, this occurrence has important diagnostic implications and the management is discussed.
Subject(s)
Abdominal Muscles/pathology , Cicatrix/pathology , Histiocytoma, Benign Fibrous/pathology , Postoperative Complications/pathology , Abdominal Muscles/surgery , Aged , Cholecystectomy , Cicatrix/surgery , Histiocytoma, Benign Fibrous/surgery , Humans , Male , Postoperative Complications/surgeryABSTRACT
The value and accuracy of aspiration cytology was assessed in the management of 444 patients presenting with a solid breast lump. The first 233 patients were assessed cytologically and frozen-section histology was performed when indicated. In this group a correct positive cytological diagnosis was made in 80% of cases. There were no false positive results. The next 211 patients were assessed cytologically and, when a firm diagnosis of malignancy was made, definitive treatment was carried out without frozen-section histology. In this group cytology was 90.6% reliable in diagnosing malignancy. No mastectomies were performed for benign disease. The use of frozen-section histology has been reduced by about 80%.
Subject(s)
Biopsy, Needle/instrumentation , Breast Neoplasms/diagnosis , Cytodiagnosis/methods , Breast Diseases/diagnosis , Cysts/diagnosis , Diagnosis, Differential , Female , Frozen Sections , Humans , Neoplasm MetastasisABSTRACT
C-reactive protein and four other acute phase reactant proteins of non-cardiac, origin (orosomucoid, alpha 1- antitrypsin, heptoglobin, and alpha 2- macroglobulin) were studied serially by laser immunonephelometric assay in sera from 17 patients with myocardial infarction. A similar comparison was made in 57 patients undergoing surgery and 72 patients with acute infection. C-reactive protein was consistently the most sensitive acute phase reactant in all three conditions. After myocardial infarction, a raised serum C-reactive protein level was found on admission in four patients before a rise in creatine kinase MB isoenzyme (CK MB). The peak C-reactive protein level was reached on the third post-infarct day and it then declined over seven days with a half-life similar to myocardial tropomyosin. Serial monitoring of serum C-reactive protein, in parallel with cardiac proteins of short half-life (CK MB) and long half-life (tropomyosin), provides maximal information for diagnosis and for detecting post-infarct complications.