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Bioorg Med Chem Lett
; 25(7): 1586-91, 2015 Apr 01.
Article
in English
| MEDLINE
| ID: mdl-25728129
ABSTRACT
Two new curcuminoids 1 and 2, and a new phenylbutenoid dimer 3, were isolated from Bangle (Zingiber purpureum). Their structures were determined on the basis of comprehensive spectroscopic data and their biogenetic pathway. Compounds 1 and 2 are the first example of curcumin coupled with phenylbutenoid. Compounds 1 and 2 promoted neurite outgrowth of NGF-mediated PC12 cells at concentrations ranging from 1 to 10 µM. In addition, compound 1 was found to accelerate the prevention of Aß42 aggregation.