[Interrelationships between the tissue link of the hemostatic system and the sympatho-adrenal system following transfusion of heterogenous blood]. / Vzaimootnosheniia mezhdu tkanevym zvenom sistemy gemostaza i simpato-adrenalovoi sistemoi pri transfuzii geterogennoi krovi

In an experiment using 86 white rats it was found that during incompatible hemotransfusion shifts take place not only in the humoral but also in the tissue link of the hemostatic system. It was also seen that the rise of the functional condition of sympatho-adrenal system precedes those changes of hemostatic figures of the tissues. The interrelationships between a tissue link of the hemostatic system and sympatho-adrenal system under the incompatible hemotransfusion were demonstrated.

[Effect of additional administration of essential amino acids on assimilability of casein hydrolysate in rats with toxic hepatitis]. / Vliianie dopolnitel'nogo primeneniia nezamenimykh aminokislot na usvoiaemost' gidrolizata kazeina u krys s toksicheskim gepatom.

The effect of certain amino acids on assimilability of casein hydrolysate was studied in albino rats with toxic hepatitis. It is established that in case of this pathology casein hydrolysate is uncapable of correcting completely the disturbed protein and nucleic metabolism. An additional administration under these conditions of amino acids, methionine in particular, changes the negative nitrogeneous balance to the positive one, that evidences for an increase in assimilability of the introduced casein hydrolysate, lowers the excretion of amino nitorgen with urea and rises the DNA content in the liver tissue. Triptophan and lysine favour an increase in the protein content in the nuclei and mitochondria of hepatocytes.

[Correction of nitrogen metabolism in rats with toxic hepatitis by parenteral administration of an amino acid mixture]. / Korrektsii azotistogo obmena parenteral'no vvedennoi aminokislotnoi smes'iu pri toksicheskom gepatite u krys.

The nitrogen metabolism in rats with toxic affection of the liver caused by administration of CCl4 was studied as affected by the amino acid mixture moriamine S-2. It is established that with toxic hepatitis the nitrogen metabolism is sharply disturbed, especially during protein deficiency. The following evidences for this fact: a rise in the depth of the nitrogen negative balance, an increase in the intensity of amine nitrogen and ammonia excretion with urea as well as an increase in the amount of amine nitrogen in blood and tissues with a simultaneous decrease in the content of protein. The parenteral administration of the amino acid mixture for eight days to the animals with a toxic affection of the liver is more effective when nitrogen preparation is combined with the group B vitamin, vitamin C, insulin, nerobolyl and sirepar.

[Effectiveness of parenteral feeding with various hydrolysates in alloxan diabetes in white rats]. / Effektivnost' parenteral'nogo pitaniia razlichnymi gidrolizatami pri alloksanovom diabete u belykh krys

The effect of applying various hydrolysates for parenteral feeding (caseine hydrolysate, hydrolysin L-103, aminosol, moriamine S-2) in albino rats with alloxan-induced diabetes was investigated. The assimilation of the hydrolysates introduced was found in these animals to be down by comparison with intact ones. It was only administration of nitrogenous media containing a sufficient amount of aminic nitrogen (moriamine S-2) that helped establish a positive nitrogenous balance and to prevent a loss of weight and the dry weight of the tissues.

[Role of the thyroid gland in the effects of parenteral feeding]. / Rol' shchitovidnoi zhelezy v éffektakh parenteral'nogo pitaniia.

In 82 albino rats with experimental thyrotoxicosis the assimilation of parenterally administered amino acid mixture of mori-amine S-2 was investigation. In thyrotoxicosis the assimilation of the amino acid mixture was found to be down. It is only a combination of mori-amine S-2 with vitamins, hormones and 6-methyluracil that facilitates the utilization of free amino acids by the tissues (this being borne out by a falling level of aminic nitrogen in the blood, skeletal muscles, heart and liver), persistently upholds the positive nitrous balance, prevents losses of the body weight and foces down oxygen consumption.

[Possibility of using the urea increment index for assessing the anabolic effectiveness of parenteral nitrogen feeding in toxic hepatitis]. / Vozmozhnost' ispol'zovaniia pokazatelia inkrementa mocheviny dlia otsenki anabolicheskoi éffektivnosti azotistogo parenteral'nogo pitaniia pri toksicheskom gepatite.

To determine the anabolic effectiveness of nitrous preparations for the parenteral alimentation an urea increment rate in normal albino rats and in the ones with parenchymatous hepatitis was used. With subcutaneous introduction of nitrous preparations moriamine S-2, aminosol, polyamine and of an improved caseine hydrolysate the level of the blood urea was found to attain the maximum in 6 hours. With toxic lesion of the liver the ureogenic function remains intact and, for this reason, this test may be used for assessing the anabolic effectiveness of the preparations with a changed functional state of the liver in different pathological conditions. The urea increment rate may be recommended for determining the biological value of the preparations for nitrogenous parenteral alimentation.

[Morphofunctional liver studies of white rats with toxic hepatitis maintained on parenteral nitrogen feeding]. / Morfofunktsional'noe issledovanie pecheni u belykh krys a toksicheskim gepatitom pri parenteral'nom azotistom pitanii.

Subcutaneous administration of noriamine S-2, a mixture of crystalline amino acids, and improved casein hydrolysate to rats on protein-free diet for 8 days completely made for protein insufficiency and did not materially affect the morphological appearance of liver tissue. in toxic hepatitis, administration of the above preparations improved liver function. However, the morphofunctional parameters did not completely return to normal.

[Hemostasis and homeostasis]. / Gemostaz i gomeostaz.

It has been established as a result of experimental and clinical studies that the phase of hypercoagulation of the DIC syndrome is marked by an appreciable increase of noradrenaline content in blood and tissues whereas the phase of hypocoagulation by a considerable diminution of the substance in blood and tissues. During hypercoagulation of the DIC syndrome, the function of mast cells in the animals' tissues rises. On the contrary, administration of heparin reduces the noradrenaline content in tissues to a considerable degree. All the four prostaglandin groups (A2, B2, F2 and E2) alter the function of the tissue component within the system of regulation of the aggregate state of the blood. At the same time their effect is determined by the specificity of the respective prostaglandin, by exposure, and by the character of the metabolism of the respective tissues. The data obtained provide new evidence in favour of the author's conception that hemostasis is a private case of homeostasis both as regards the biological significance of the process and its common character with respect to the neuroendocrine forms of regulation.

[Biochemical mechanisms of the effect of prostaglandin E2 on the effect of parenteral nitrogenous nutrition]. / Nekotorye biokhimicheskie mekhanizmy vliiania prostaglandina E2 na éffekty parenteral'nogo azotistogo pitaniia.

Activation of lipid peroxidation (LPP) processes in the hepatocytes of animals suffering from toxic hepatitis leads to disorders of membrane function and causes disorders of transports processes (activity of adenosine triphosphatase, active sodium transport) in them. Administration of prostaglandin E2 (PGE2) as a potent antioxidant simultaneously with casein hydrolysate to animals with experimental pathology intensifies the effect of the nitrous preparation and promotes normalization of the studied processes (LPP, adenosine triphosphatase activity, active sodium transport). Thus, through its action on LPP and the transport systems, PGE2 influences the effect of casein hydrolysate.

[The effect of prostaglandin E2 on transport processes in the hepatocytes during parenteral feeding against a background of protein starvation]. / Vliianie prostaglandina E2 na transportnye protsessy v gepatotsitakh pri parenteral'nom pitanii na fone belkovogo golodaniia.

Experiments were conducted in 50 white rats (180-220 g bw). Activities of total, Mg2-dependent, Na+, K+ and Ca2(+)-ATPases and sodium transport in hepatocytes of the animals under normal conditions and in the presence of protein deficiency were studied in five test series. Protein deficiency was found to be attended by a significant rise in the activity of the enzymes studied, and by disorders in sodium transport in hepatocytes. Administration of casein hydrolysate, in the presence of protein deficiency in the animals, induced a tendency to normalization of the processes studied. Casein hydrolysate used simultaneously with PGE2 produced more pronounced changes in ATP activity and sodium transport in hepatocytes. Basing on the results of the investigations it has been suggested that casein hydrolysate effect can be intensified by PGE2, thus it can be widely used in clinical practice.