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1.

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome.

Hirsch, Pascal; Tagirdzhanov, Azat; Kushnareva, Aleksandra; Olkhovskii, Ilia; Graf, Simon; Schmartz, Georges P; Hegemann, Julian D; Bozhüyük, Kenan A J; Müller, Rolf; Keller, Andreas; Gurevich, Alexey.

Nucleic Acids Res ; 52(D1): D579-D585, 2024 Jan 05.

Article in English | MEDLINE | ID: mdl-37994699

2.

Current developments in antibiotic discovery: Global microbial diversity as a source for evolutionary optimized anti-bacterials: Global microbial diversity as a source for evolutionary optimized anti-bacterials.

Hegemann, Julian D; Birkelbach, Joy; Walesch, Sebastian; Müller, Rolf.

EMBO Rep ; 24(1): e56184, 2023 01 09.

Article in English | MEDLINE | ID: mdl-36541849

3.

Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials.

Walesch, Sebastian; Birkelbach, Joy; Jézéquel, Gwenaëlle; Haeckl, F P Jake; Hegemann, Julian D; Hesterkamp, Thomas; Hirsch, Anna K H; Hammann, Peter; Müller, Rolf.

EMBO Rep ; 24(1): e56033, 2023 01 09.

Article in English | MEDLINE | ID: mdl-36533629

4.

The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide.

Baquero, Fernando; Beis, Konstantinos; Craik, David J; Li, Yanyan; Link, A James; Rebuffat, Sylvie; Salomón, Raúl; Severinov, Konstantin; Zirah, Séverine; Hegemann, Julian D.

Nat Prod Rep ; 41(3): 469-511, 2024 Mar 20.

Article in English | MEDLINE | ID: mdl-38164764

5.

Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT.

Sarksian, Raymond; Hegemann, Julian D; Simon, Max A; Acedo, Jeella Z; van der Donk, Wilfred A.

J Am Chem Soc ; 144(14): 6373-6382, 2022 04 13.

Article in English | MEDLINE | ID: mdl-35352944

6.

Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions.

Huang, Shanqing; Wang, Ying; Cai, Chuangxu; Xiao, Xiuyun; Liu, Shulei; Ma, Yeying; Xie, Xiangqian; Liang, Yong; Chen, Hao; Zhu, Jiapeng; Hegemann, Julian D; Yao, Hongwei; Wei, Wanqing; Wang, Huan.

Angew Chem Int Ed Engl ; 61(45): e202211382, 2022 11 07.

Article in English | MEDLINE | ID: mdl-36102578

7.

Identification of the Catalytic Residues in the Cyclase Domain of the Class IV Lanthipeptide Synthetase SgbL.

Hegemann, Julian D; Süssmuth, Roderich D.

Chembiochem ; 22(22): 3169-3172, 2021 11 16.

Article in English | MEDLINE | ID: mdl-34490957

8.

Exploring structural signatures of the lanthipeptide prochlorosin 2.8 using tandem mass spectrometry and trapped ion mobility-mass spectrometry.

Jeanne Dit Fouque, Kevin; Hegemann, Julian D; Santos-Fernandez, Miguel; Le, Tung T; Gomez-Hernandez, Mario; van der Donk, Wilfred A; Fernandez-Lima, Francisco.

Anal Bioanal Chem ; 413(19): 4815-4824, 2021 Aug.

Article in English | MEDLINE | ID: mdl-34105020

9.

A Bifunctional Leader Peptidase/ABC Transporter Protein Is Involved in the Maturation of the Lasso Peptide Cochonodin I from Streptococcus suis.

Hegemann, Julian D; Jeanne Dit Fouque, Kevin; Santos-Fernandez, Miguel; Fernandez-Lima, Francisco.

J Nat Prod ; 84(10): 2683-2691, 2021 10 22.

Article in English | MEDLINE | ID: mdl-34597519

10.

Generation of Lasso Peptide-Based ClpP Binders.

Malik, Imran T; Hegemann, Julian D; Brötz-Oesterhelt, Heike.

Int J Mol Sci ; 23(1)2021 Dec 31.

Article in English | MEDLINE | ID: mdl-35008890

11.

Light-Controlled Tyrosine Nitration of Proteins.

Long, Tengfang; Liu, Lei; Tao, Youqi; Zhang, Wanli; Quan, Jiale; Zheng, Jie; Hegemann, Julian D; Uesugi, Motonari; Yao, Wenbing; Tian, Hong; Wang, Huan.

Angew Chem Int Ed Engl ; 60(24): 13414-13422, 2021 06 07.

Article in English | MEDLINE | ID: mdl-33847040

12.

Factors Governing the Thermal Stability of Lasso Peptides.

Hegemann, Julian D.

Chembiochem ; 21(1-2): 7-18, 2020 01 15.

Article in English | MEDLINE | ID: mdl-31243865

13.

Structural signatures of the class III lasso peptide BI-32169 and the branched-cyclic topoisomers using trapped ion mobility spectrometry-mass spectrometry and tandem mass spectrometry.

Jeanne Dit Fouque, Kevin; Bisram, Vikash; Hegemann, Julian D; Zirah, Séverine; Rebuffat, Sylvie; Fernandez-Lima, Francisco.

Anal Bioanal Chem ; 411(24): 6287-6296, 2019 Sep.

Article in English | MEDLINE | ID: mdl-30707269

14.

Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems.

Hegemann, Julian D; van der Donk, Wilfred A.

J Am Chem Soc ; 140(17): 5743-5754, 2018 05 02.

Article in English | MEDLINE | ID: mdl-29633842

15.

Identification of Lasso Peptide Topologies Using Native Nanoelectrospray Ionization-Trapped Ion Mobility Spectrometry-Mass Spectrometry.

Dit Fouque, Kevin Jeanne; Moreno, Javier; Hegemann, Julian D; Zirah, Séverine; Rebuffat, Sylvie; Fernandez-Lima, Francisco.

Anal Chem ; 90(8): 5139-5146, 2018 04 17.

Article in English | MEDLINE | ID: mdl-29579382

16.

Metal ions induced secondary structure rearrangements: mechanically interlocked lasso vs. unthreaded branched-cyclic topoisomers.

Jeanne Dit Fouque, Kevin; Moreno, Javier; Hegemann, Julian D; Zirah, Séverine; Rebuffat, Sylvie; Fernandez-Lima, Francisco.

Analyst ; 143(10): 2323-2333, 2018 May 15.

Article in English | MEDLINE | ID: mdl-29721555

17.

Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System.

Martin-Gómez, Helena; Linne, Uwe; Albericio, Fernando; Tulla-Puche, Judit; Hegemann, Julian D.

J Nat Prod ; 81(9): 2050-2056, 2018 09 28.

Article in English | MEDLINE | ID: mdl-30178995

18.

Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin.

Zhu, Shaozhou; Hegemann, Julian D; Fage, Christopher D; Zimmermann, Marcel; Xie, Xiulan; Linne, Uwe; Marahiel, Mohamed A.

J Biol Chem ; 291(26): 13662-78, 2016 Jun 24.

Article in English | MEDLINE | ID: mdl-27151214

19.

Lasso peptides: an intriguing class of bacterial natural products.

Hegemann, Julian D; Zimmermann, Marcel; Xie, Xiulan; Marahiel, Mohamed A.

Acc Chem Res ; 48(7): 1909-19, 2015 Jul 21.

Article in English | MEDLINE | ID: mdl-26079760

20.

Structure and Mechanism of the SphingopyxinâI Lasso Peptide Isopeptidase.

Fage, Christopher D; Hegemann, Julian D; Nebel, Annika J; Steinbach, Roman M; Zhu, Shaozhou; Linne, Uwe; Harms, Klaus; Bange, Gert; Marahiel, Mohamed A.

Angew Chem Int Ed Engl ; 55(41): 12717-21, 2016 10 04.

Article in English | MEDLINE | ID: mdl-27611791

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