Search | VHL Search Portal

1.

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.

Allouche, Jennifer; Rachmin, Inbal; Adhikari, Kaustubh; Pardo, Luba M; Lee, Ju Hee; McConnell, Alicia M; Kato, Shinichiro; Fan, Shaohua; Kawakami, Akinori; Suita, Yusuke; Wakamatsu, Kazumasa; Igras, Vivien; Zhang, Jianming; Navarro, Paula P; Lugo, Camila Makhlouta; Noonan, Haley R; Christie, Kathleen A; Itin, Kaspar; Mujahid, Nisma; Lo, Jennifer A; Won, Chong Hyun; Evans, Conor L; Weng, Qing Yu; Wang, Hequn; Osseiran, Sam; Lovas, Alyssa; Németh, István; Cozzio, Antonio; Navarini, Alexander A; Hsiao, Jennifer J; Nguyen, Nhu; Kemény, Lajos V; Iliopoulos, Othon; Berking, Carola; Ruzicka, Thomas; Gonzalez-José, Rolando; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Acuna-Alonso, Victor; Gallo, Carla; Poletti, Giovanni; Bedoya, Gabriel; Rothhammer, Francisco; Ito, Shosuke; Schiaffino, Maria Vittoria; Chao, Luke H; Kleinstiver, Benjamin P; Tishkoff, Sarah; Zon, Leonard I; Nijsten, Tamar.

Cell ; 184(16): 4268-4283.e20, 2021 08 05.

Article in English | MEDLINE | ID: mdl-34233163

2.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Zhong, Lei; D'Urso, Agustina; Toiber, Debra; Sebastian, Carlos; Henry, Ryan E; Vadysirisack, Douangsone D; Guimaraes, Alexander; Marinelli, Brett; Wikstrom, Jakob D; Nir, Tomer; Clish, Clary B; Vaitheesvaran, Bhavapriya; Iliopoulos, Othon; Kurland, Irwin; Dor, Yuval; Weissleder, Ralph; Shirihai, Orian S; Ellisen, Leif W; Espinosa, Joaquin M; Mostoslavsky, Raul.

Cell ; 140(2): 280-93, 2010 Jan 22.

Article in English | MEDLINE | ID: mdl-20141841

3.

Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.

Jonasch, Eric; Donskov, Frede; Iliopoulos, Othon; Rathmell, W Kimryn; Narayan, Vivek K; Maughan, Benjamin L; Oudard, Stephane; Else, Tobias; Maranchie, Jodi K; Welsh, Sarah J; Thamake, Sanjay; Park, Eric K; Perini, Rodolfo F; Linehan, W Marston; Srinivasan, Ramaprasad.

N Engl J Med ; 385(22): 2036-2046, 2021 11 25.

Article in English | MEDLINE | ID: mdl-34818478

4.

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.

Black, Joshua C; Atabakhsh, Elnaz; Kim, Jaegil; Biette, Kelly M; Van Rechem, Capucine; Ladd, Brendon; Burrowes, Paul D; Donado, Carlos; Mattoo, Hamid; Kleinstiver, Benjamin P; Song, Bing; Andriani, Grasiella; Joung, J Keith; Iliopoulos, Othon; Montagna, Cristina; Pillai, Shiv; Getz, Gad; Whetstine, Johnathan R.

Genes Dev ; 29(10): 1018-31, 2015 May 15.

Article in English | MEDLINE | ID: mdl-25995187

5.

Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement.

Bratslavsky, Gennady; Mendhiratta, Neil; Daneshvar, Michael; Brugarolas, James; Ball, Mark W; Metwalli, Adam; Nathanson, Katherine L; Pierorazio, Phillip M; Boris, Ronald S; Singer, Eric A; Carlo, Maria I; Daly, Mary B; Henske, Elizabeth P; Hyatt, Colette; Middleton, Lindsay; Morris, Gloria; Jeong, Anhyo; Narayan, Vivek; Rathmell, W Kimryn; Vaishampayan, Ulka; Lee, Bruce H; Battle, Dena; Hall, Michael J; Hafez, Khaled; Jewett, Michael A S; Karamboulas, Christina; Pal, Sumanta K; Hakimi, A Ari; Kutikov, Alexander; Iliopoulos, Othon; Linehan, W Marston; Jonasch, Eric; Srinivasan, Ramaprasad; Shuch, Brian.

Cancer ; 127(21): 3957-3966, 2021 Nov 01.

Article in English | MEDLINE | ID: mdl-34343338

6.

Evaluation, diagnosis and surveillance of renal masses in the setting of VHL disease.

Chahoud, Jad; McGettigan, Melissa; Parikh, Nainesh; Boris, Ronald S; Iliopoulos, Othon; Rathmell, W Kimryn; Daniels, Anthony B; Jonasch, Eric; Spiess, Philippe E.

World J Urol ; 39(7): 2409-2415, 2021 Jul.

Article in English | MEDLINE | ID: mdl-32936333

7.

Loss of RBF1 changes glutamine catabolism.

Nicolay, Brandon N; Gameiro, Paulo A; Tschöp, Katrin; Korenjak, Michael; Heilmann, Andreas M; Asara, John M; Stephanopoulos, Gregory; Iliopoulos, Othon; Dyson, Nicholas J.

Genes Dev ; 27(2): 182-96, 2013 Jan 15.

Article in English | MEDLINE | ID: mdl-23322302

8.

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.

Metallo, Christian M; Gameiro, Paulo A; Bell, Eric L; Mattaini, Katherine R; Yang, Juanjuan; Hiller, Karsten; Jewell, Christopher M; Johnson, Zachary R; Irvine, Darrell J; Guarente, Leonard; Kelleher, Joanne K; Vander Heiden, Matthew G; Iliopoulos, Othon; Stephanopoulos, Gregory.

Nature ; 481(7381): 380-4, 2011 Nov 20.

Article in English | MEDLINE | ID: mdl-22101433

9.

Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass.

Dahl, Douglas M; Simeone, Joseph F; Iliopoulos, Othon; Saylor, Philip J; Wu, Chin-Lee.

N Engl J Med ; 379(21): 2064-2072, 2018 11 22.

Article in English | MEDLINE | ID: mdl-30462933

10.

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

Zimmer, Michael; Ebert, Benjamin L; Neil, Christopher; Brenner, Keith; Papaioannou, Ioannis; Melas, Antonia; Tolliday, Nicola; Lamb, Justin; Pantopoulos, Kostas; Golub, Todd; Iliopoulos, Othon.

Mol Cell ; 32(6): 838-48, 2008 Dec 26.

Article in English | MEDLINE | ID: mdl-19111663

11.

Clusterin glycopeptide variant characterization reveals significant site-specific glycan changes in the plasma of clear cell renal cell carcinoma.

Gbormittah, Francisca O; Bones, Jonathan; Hincapie, Marina; Tousi, Fateme; Hancock, William S; Iliopoulos, Othon.

J Proteome Res ; 14(6): 2425-36, 2015 Jun 05.

Article in English | MEDLINE | ID: mdl-25855029

12.

Comparative studies of the proteome, glycoproteome, and N-glycome of clear cell renal cell carcinoma plasma before and after curative nephrectomy.

Gbormittah, Francisca O; Lee, Ling Y; Taylor, KyOnese; Hancock, William S; Iliopoulos, Othon.

J Proteome Res ; 13(11): 4889-900, 2014 Nov 07.

Article in English | MEDLINE | ID: mdl-25184692

13.

Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.

Gameiro, Paulo A; Laviolette, Laura A; Kelleher, Joanne K; Iliopoulos, Othon; Stephanopoulos, Gregory.

J Biol Chem ; 288(18): 12967-77, 2013 May 03.

Article in English | MEDLINE | ID: mdl-23504317

14.

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.

Else, Tobias; Jonasch, Eric; Iliopoulos, Othon; Beckermann, Kathryn E; Narayan, Vivek; Maughan, Benjamin L; Oudard, Stephane; Maranchie, Jodi K; Iversen, Ane B; Goldberg, Cynthia M; Fu, Wei; Perini, Rodolfo F; Liu, Yanfang; Linehan, W Marston; Srinivasan, Ramaprasad.

Clin Cancer Res ; 30(9): 1750-1757, 2024 May 01.

Article in English | MEDLINE | ID: mdl-38393723

15.

Diseases of Hereditary Renal Cell Cancers.

Iliopoulos, Othon.

Urol Clin North Am ; 50(2): 205-215, 2023 May.

Article in English | MEDLINE | ID: mdl-36948667

16.

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species.

Roider, Elisabeth; Lakatos, Alexandra I T; McConnell, Alicia M; Wang, Poguang; Mueller, Alina; Kawakami, Akinori; Tsoi, Jennifer; Szabolcs, Botond L; Ascsillán, Anna A; Suita, Yusuke; Igras, Vivien; Lo, Jennifer A; Hsiao, Jennifer J; Lapides, Rebecca; Pál, Dorottya M P; Lengyel, Anna S; Navarini, Alexander; Okazaki, Arimichi; Iliopoulos, Othon; Németh, István; Graeber, Thomas G; Zon, Leonard; Giese, Roger W; Kemeny, Lajos V; Fisher, David E.

bioRxiv ; 2023 Nov 14.

Article in English | MEDLINE | ID: mdl-38014031

17.

Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

Mizukami, Yusuke; Jo, Won-Seok; Duerr, Eva-Maria; Gala, Manish; Li, Jingnan; Zhang, Xiaobo; Zimmer, Michael A; Iliopoulos, Othon; Zukerberg, Lawrence R; Kohgo, Yutaka; Lynch, Maureen P; Rueda, Bo R; Chung, Daniel C.

Nat Med ; 11(9): 992-7, 2005 Sep.

Article in English | MEDLINE | ID: mdl-16127434

18.

Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL.

Arevalo, Aileen; Patel, Neal; Muraki, Peter; Ohtake, Shinji; Bratslavsky, Gennady; Clark, Chandra; Mann, Joshua; Iliopoulos, Othon; Jonasch, Eric; Srinivasan, Ramaprasad; Shuch, Brian.

J Kidney Cancer VHL ; 9(3): 41-46, 2022.

Article in English | MEDLINE | ID: mdl-36310638

19.

Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial.

Meric-Bernstam, Funda; Tannir, Nizar M; Iliopoulos, Othon; Lee, Richard J; Telli, Melinda L; Fan, Alice C; DeMichele, Angela; Haas, Naomi B; Patel, Manish R; Harding, James J; Voss, Martin H; Owonikoko, Taofeek K; Carthon, Bradley; Srinivasan, Ramaprasad; Bendell, Johanna C; Jenkins, Yonchu; Whiting, Sam H; Orford, Keith; Bennett, Mark K; Bauer, Todd M.

Clin Cancer Res ; 28(8): 1540-1548, 2022 04 14.

Article in English | MEDLINE | ID: mdl-35140121

20.

Seventh BHD international symposium: recent scientific and clinical advancement.

Woodford, Mark R; Andreou, Avgi; Baba, Masaya; van de Beek, Irma; Di Malta, Chiara; Glykofridis, Iris; Grimes, Hannah; Henske, Elizabeth P; Iliopoulos, Othon; Kurihara, Masatoshi; Lazor, Romain; Linehan, W Marston; Matsumoto, Kenki; Marciniak, Stefan J; Namba, Yukiko; Pause, Arnim; Rajan, Neil; Ray, Anindita; Schmidt, Laura S; Shi, Wei; Steinlein, Ortrud K; Thierauf, Julia; Zoncu, Roberto; Webb, Anna; Mollapour, Mehdi.

Oncotarget ; 13: 173-181, 2022.

Article in English | MEDLINE | ID: mdl-35070081

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