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1.
Antibacterial activity of some 5-dialkylaminomethylhydantoins and related derivatives.
Fujisaki, Fumiko; Toyofuku, Keiko; Egami, Mayu; Ishida, Shiori; Nakamoto, Naho; Kashige, Nobuhiro; Miake, Fumio; Sumoto, Kunihiro.
Chem Pharm Bull (Tokyo) ; 61(10): 1090-3, 2013.
Article in English | MEDLINE | ID: mdl-24088702

ABSTRACT

In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C2-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.


Subject(s)
Anti-Bacterial Agents/chemistry , Hydantoins/chemistry , Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Escherichia coli/drug effects , Hydantoins/chemical synthesis , Hydantoins/pharmacology , Microbial Sensitivity Tests , Staphylococcus aureus/drug effects , Structure-Activity Relationship
2.
Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.
Ikeda, Fumika; Yoshida, Kenichi; Toki, Tsutomu; Uechi, Tamayo; Ishida, Shiori; Nakajima, Yukari; Sasahara, Yoji; Okuno, Yusuke; Kanezaki, Rika; Terui, Kiminori; Kamio, Takuya; Kobayashi, Akie; Fujita, Takashi; Sato-Otsubo, Aiko; Shiraishi, Yuichi; Tanaka, Hiroko; Chiba, Kenichi; Muramatsu, Hideki; Kanno, Hitoshi; Ohga, Shouichi; Ohara, Akira; Kojima, Seiji; Kenmochi, Naoya; Miyano, Satoru; Ogawa, Seishi; Ito, Etsuro.
Haematologica ; 102(3): e93-e96, 2017 03.
Article in English | MEDLINE | ID: mdl-27909223

Subject(s)
Anemia, Diamond-Blackfan/genetics , Exome , Haploinsufficiency , Point Mutation , RNA, Ribosomal, 18S/genetics , Ribosomal Proteins/genetics , Adult , Alternative Splicing , Anemia, Diamond-Blackfan/metabolism , Anemia, Diamond-Blackfan/pathology , Animals , CRISPR-Cas Systems , Cell Proliferation , Child, Preschool , Embryo, Nonmammalian , Exons , Female , Gene Editing , Gene Expression , Humans , Infant , K562 Cells , Pedigree , RNA, Ribosomal, 18S/metabolism , Ribosomal Proteins/deficiency , Siblings , Exome Sequencing , Zebrafish
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