1.
Chem Pharm Bull (Tokyo)
; 61(10): 1090-3, 2013.
Article
in English
| MEDLINE
| ID: mdl-24088702
ABSTRACT
In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C2-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.
Subject(s)
Anti-Bacterial Agents/chemistry , Hydantoins/chemistry , Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Escherichia coli/drug effects , Hydantoins/chemical synthesis , Hydantoins/pharmacology , Microbial Sensitivity Tests , Staphylococcus aureus/drug effects , Structure-Activity Relationship
2.
Haematologica
; 102(3): e93-e96, 2017 03.
Article
in English
| MEDLINE
| ID: mdl-27909223