ABSTRACT
Basing on their rich clinical and experimental experience the authors conclude that hyperglycemia in purulent conditions results from receptors insufficiency of somatic cells membranes which arises due to either their block or destruction by endotoxicosis factors which are likely to be of leukocytic nature. Early cleansing of the purulent focus and detoxication provide normalization of the carbohydrate metabolism.
Subject(s)
Hyperglycemia/diagnosis , Adult , Aged , Cholangitis/complications , Cholecystitis/complications , Humans , Hyperglycemia/complications , Middle Aged , Peritonitis/complications , Pyelonephritis/complications , Suppuration/complicationsABSTRACT
On the basis of personal investigations and literature data the author considers metastatic abscesses in sepsis to be formed in necrosis foci resulting from the action of proteolytic enzymes, prostaglandins, cationic proteins and leukocytes with pathogenic microbes included.
Subject(s)
Abscess/transmission , Bacterial Infections/transmission , Sepsis/microbiology , Abscess/microbiology , Bacterial Infections/microbiology , Embolism/microbiology , HumansABSTRACT
On the basis of clinical observations and literature data the author made a conclusion concerning the development of disseminated necrosis in the abdominal organs following massive profuse gastroduodenal hemorrhages. The earlier idea of the toxic effect of the blood collected in the intestine has neither clinical nor experimental support.
Subject(s)
Digestive System/blood supply , Gastrointestinal Hemorrhage/complications , Ischemia/etiology , Acute Disease , Duodenal Diseases/complications , Fever/etiology , Gastrointestinal Hemorrhage/surgery , Humans , Leukocytosis/etiology , Necrosis , Stomach Diseases/complications , Time FactorsABSTRACT
Based on clinical observations of pyo-necrotic lesions of the foot in patients with diabetic mellitus and on an analysis of their personal operations performed on these patients the authors support the tendency to local necrotomies. Two original operations are proposed: ablation of the great toe with a preliminary transection of the tendon of the long flexor and radical operation of the deep phlegmon of the foot with the dissection of plantar aponeurosis and short flexors of the toes. These methods allow the general amount of amputations and lethality to be decreased.
Subject(s)
Cellulitis/prevention & control , Diabetic Angiopathies/complications , Foot Diseases/complications , Amputation, Surgical , Bacteria, Anaerobic , Bacterial Infections/etiology , Bacterial Infections/prevention & control , Bacterial Infections/surgery , Cellulitis/etiology , Cellulitis/surgery , Diabetic Angiopathies/surgery , Foot/pathology , Foot/surgery , Foot Diseases/etiology , Foot Diseases/surgery , Humans , Necrosis/surgery , Sympathectomy , Tendons/surgery , Toes/pathology , Toes/surgeryABSTRACT
The content of cationic proteins in leukocytes was established in 65 patients with peritonitis and purulent diseases of soft tissues. It was established that all of the patients had a decreased content of cationic proteins in the granules of polymorphonuclear leukocytes, its degree depending on the gravity of the pyo-inflammatory process. The authors consider it to be associated with the release of cationic proteins and proteolytic enzymes into the circulating blood and to be of value in the improvement of antimicrobial properties of blood.
Subject(s)
Blood Proteins/analysis , Neutrophils/analysis , Suppuration/blood , Adult , Blood Bactericidal Activity , Cations , Humans , Male , Middle Aged , Peritonitis/blood , Time FactorsABSTRACT
Under study was the kinetics of changes in the kinin content, the activity of kininase and blood proteolytic activity in acute purulent peritonitis in 63 patients. The kinin activity was judged indirectly by the kinin level in blood. The results of the study indicated that in acute purulent peritonitis the kinin concentration in blood is decreased in proportion with the gravity of the disease course.
Subject(s)
Kinins/blood , Peritonitis/blood , Acute Disease , Adult , Aged , Bradykinin/blood , Humans , Kininogens/blood , Lysine Carboxypeptidase/blood , Peptidyl-Dipeptidase A/blood , Peritonitis/enzymologyABSTRACT
Jejunostomy was put in 21 patients operated on the gastrointestinal tract, and on the 3-4 day after operation it was used for entero-probe nutrition (amino acid mixtures, fat emulsions, glucose solutions meant for parenteral nutrition, 3 1 a day at a speed 30-50 drops per minute). Clinical observations have shown high therapeutic effect, safely and technical simplicity of this entero-probe nutrition.
Subject(s)
Amino Acids/administration & dosage , Dietary Fats/administration & dosage , Digestive System Diseases/surgery , Enteral Nutrition/methods , Glucose/administration & dosage , Jejunostomy , Adult , Aged , Female , Humans , Male , Middle Aged , Postoperative CareABSTRACT
The level of cationic proteins was studied in 52 patients with peritonitis and purulent processes of soft tissues. The authors have shown its elevation to be dependent on the degree of the disease. The improved state of the patients and recovery was followed by a decreased content of cationic proteins in blood, their fractional composition being normalized.