ABSTRACT
Proceeding from the G. I. Kozinets et al. (1977) classification of human red cells, 9 types of red cells were distinguished with scanning electron microscopy in peripheral blood of Wistar male rats: discocytes, discocytes with processes on their surface, mulberry-like red cells, dome-like red cells, spherical red cells with smooth and rough surface, red cells similar to a flat ball, degeneratively altered red cells. Percentage of different shapes of the erythrocytes was determined.
Subject(s)
Erythrocytes/cytology , Animals , Male , Microscopy, Electron, Scanning , Rats , Rats, Inbred StrainsABSTRACT
Hemophiliac patients develop disorders of the immune status as a result of transfusion therapy: a decrease in the number of T-lymphocytes and the ratio T-helpers/T-suppressors resulting from a decrease in the number of T-helpers, enhancement of immunoglobulinogenesis, and an increase in the level of circulating immune complexes. A degree of the above changes depends on a dose and period of the use of antihemophilic drugs. Hemophiliac patients require immunological monitoring, clinical substantiation of doses and a prolonged period of administration of blood preparations.
Subject(s)
Hemophilia A/complications , Immune System Diseases/etiology , Acute Disease , Adolescent , Adult , Blood Transfusion , Dose-Response Relationship, Immunologic , Factor VIII/administration & dosage , Hemophilia A/immunology , Hemophilia A/therapy , Hemophilia B/complications , Hemophilia B/immunology , Hemophilia B/therapy , Hemorrhage/etiology , Hemorrhage/immunology , Humans , Immune System Diseases/immunology , Immune System Diseases/therapy , Immunity, Cellular , Immunoglobulins/analysis , Time FactorsABSTRACT
The experiments on guinea pigs and male CBA mice have shown that short-term daily administration of lipidin-2 (3 infusions) in a dose of 2 g/kg induces a decrease in T-lymphocyte proliferative activity. Increased multiplicity of the agent infusions up to 7 and 14 is attended by reversible quantitative and functional changes in the T-lymphocyte population and D-cells.
Subject(s)
Fat Emulsions, Intravenous/pharmacology , Immunity, Cellular/drug effects , Phospholipids/pharmacology , Plant Oils/pharmacology , Animals , Dietary Fats, Unsaturated/administration & dosage , Dietary Fats, Unsaturated/pharmacology , Emulsions , Fat Emulsions, Intravenous/administration & dosage , Glycerol , Guinea Pigs , Leukocyte Count/drug effects , Male , Mice , Mice, Inbred CBA , Parenteral Nutrition , Phospholipids/administration & dosage , Plant Oils/administration & dosage , Sunflower Oil , T-Lymphocytes/drug effects , T-Lymphocytes/immunology , Time FactorsABSTRACT
The influence of an intralipid fatty emulsion on the absorbability of polyamine amino acid mixtures was studied during their administration through a tube into the duodenum of white rats. Polyamine was administered in a dose of 0.25 g of nominal protein, intralipid in a dose of 0.2 g of fat/g bw/day. It was found that polyamine administered into the small intestine was intensely absorbed during the first two hours which was evidence by an increased content of amino acids in the blood. Intralipid used simultaneously with polyamine intensified the absorption of the latter. Preliminary administration of intralipid promoted a more rapid polyamine absorption, especially of side branch chain amino acids. The results obtained have presented an experimental validation of using nitrous compounds after preliminary administration of fatty emulsions in enteral tube feeding.
Subject(s)
Amino Acids/blood , Enteral Nutrition , Fat Emulsions, Intravenous/administration & dosage , Amino Acids/administration & dosage , Animals , Fat Emulsions, Intravenous/metabolism , Intestinal Absorption , Male , RatsABSTRACT
Hemoblastosis morbidity in children and adult populations and its structure were studied during the period of 1981-1992 at Rovensky district of Ukraine, 6 northern districts of which were affected by radionuclides after Chernobyl AES accident. Primary documentation, actual and archival records were the object of study: registration diaries, records and ambulatory cards. Expeditional method of investigation. During the last 11 years a rise of hemoblastosise morbidity was stated in Rovensky district, especially after the accident, and it was confirmed by a profound statistical analysis of data on leukemia morbidity before and after the accident. Among different nosological forms after the accident the rate of leukemia morbidity as well as myeloma disease and malignant lymphoma morbidity, rose markedly. No significant difference was marked in hemoblastoses (excluding acute leukemia) in non-contaminated and contaminated with radionuclides regions of the district, and in contaminated zones depending on effective equivalent doze. Acute leukemia morbidity in contaminated regions after the accident was statistically reliably higher.
Subject(s)
Accidents , Leukemia, Radiation-Induced/epidemiology , Neoplasms, Radiation-Induced/epidemiology , Nuclear Reactors , Adult , Child , Humans , Retrospective Studies , Ukraine/epidemiologyABSTRACT
Jejunostomy was put in 21 patients operated on the gastrointestinal tract, and on the 3-4 day after operation it was used for entero-probe nutrition (amino acid mixtures, fat emulsions, glucose solutions meant for parenteral nutrition, 3 1 a day at a speed 30-50 drops per minute). Clinical observations have shown high therapeutic effect, safely and technical simplicity of this entero-probe nutrition.