Search details
1.
Structural basis for dual-mode inhibition of the ABC transporter MsbA.
Nature
; 557(7704): 196-201, 2018 05.
Article
in English
| MEDLINE | ID: mdl-29720648
2.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Article
in English
| MEDLINE | ID: mdl-35065235
3.
Enyne Amides to Fused Pyridones: Scope and Limitations.
J Org Chem
; 86(20): 14177-14191, 2021 10 15.
Article
in English
| MEDLINE | ID: mdl-34337936
4.
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
Bioorg Med Chem Lett
; 29(16): 2090-2093, 2019 08 15.
Article
in English
| MEDLINE | ID: mdl-31311734
5.
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
Bioorg Med Chem Lett
; 26(18): 4492-4496, 2016 09 15.
Article
in English
| MEDLINE | ID: mdl-27499454
6.
Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity.
J Med Chem
; 65(5): 4085-4120, 2022 03 10.
Article
in English
| MEDLINE | ID: mdl-35184554
7.
A novel series of IKKß inhibitors part II: description of a potent and pharmacologically active series of analogs.
Bioorg Med Chem Lett
; 21(1): 423-6, 2011 Jan 01.
Article
in English
| MEDLINE | ID: mdl-21074992
8.
A novel series of IKKß inhibitors part I: Initial SAR studies of a HTS hit.
Bioorg Med Chem Lett
; 21(1): 417-22, 2011 Jan 01.
Article
in English
| MEDLINE | ID: mdl-21074993
9.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem
; 64(16): 11841-11856, 2021 08 26.
Article
in English
| MEDLINE | ID: mdl-34251202
10.
Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.
J Med Chem
; 49(5): 1562-75, 2006 Mar 09.
Article
in English
| MEDLINE | ID: mdl-16509574
11.
Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
ACS Med Chem Lett
; 7(10): 896-901, 2016 Oct 13.
Article
in English
| MEDLINE | ID: mdl-27774125
12.
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1914-31, 2014 Mar 13.
Article
in English
| MEDLINE | ID: mdl-24195700
13.
De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.
J Med Chem
; 56(7): 3115-9, 2013 Apr 11.
Article
in English
| MEDLINE | ID: mdl-23509929
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