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1.
Proc Natl Acad Sci U S A ; 117(12): 6936-6941, 2020 03 24.
Article in English | MEDLINE | ID: mdl-32152105

ABSTRACT

The growth of the internet has spawned new "attention markets," in which people devote increasing amounts of time to consuming online content, but the neurobehavioral mechanisms that drive engagement in these markets have yet to be elucidated. We used functional MRI (FMRI) to examine whether individuals' neural responses to videos could predict their choices to start and stop watching videos as well as whether group brain activity could forecast aggregate video view frequency and duration out of sample on the internet (i.e., on youtube.com). Brain activity during video onset predicted individual choice in several regions (i.e., increased activity in the nucleus accumbens [NAcc] and medial prefrontal cortex [MPFC] as well as decreased activity in the anterior insula [AIns]). Group activity during video onset in only a subset of these regions, however, forecasted both aggregate view frequency and duration (i.e., increased NAcc and decreased AIns)-and did so above and beyond conventional measures. These findings extend neuroforecasting theory and tools by revealing that activity in brain regions implicated in anticipatory affect at the onset of video viewing (but not initial choice) can forecast time allocation out of sample in an internet attention market.


Subject(s)
Attention/physiology , Brain/physiology , Choice Behavior , Internet/statistics & numerical data , Nervous System Physiological Phenomena , Social Media , Video Recording , Adult , Cerebral Cortex/physiology , Female , Humans , Magnetic Resonance Imaging , Male , Nucleus Accumbens/physiology , Prefrontal Cortex/physiology
2.
Int J Mol Sci ; 23(10)2022 May 10.
Article in English | MEDLINE | ID: mdl-35628128

ABSTRACT

Lipid structural diversity strongly affects biomembrane chemico-physical and structural properties in addition to membrane-associated events. At high concentrations, cholesterol increases membrane order and rigidity, while polyunsaturated lipids are reported to increase disorder and flexibility. How these different tendencies balance in composite bilayers is still controversial. In this study, electron paramagnetic resonance spectroscopy, small angle neutron scattering, and neutron reflectivity were used to investigate the structural properties of cholesterol-containing lipid bilayers in the fluid state with increasing amounts of polyunsaturated omega-3 lipids. Either the hybrid 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine or the symmetric 1,2-docosahexaenoyl-sn-glycero-3-phosphocholine were added to the mixture of the naturally abundant 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine and cholesterol. Our results indicate that the hybrid and the symmetric omega-3 phospholipids affect the microscopic organization of lipid bilayers differently. Cholesterol does not segregate from polyunsaturated phospholipids and, through interactions with them, is able to suppress the formation of non-lamellar structures induced by the symmetric polyunsaturated lipid. However, this order/disorder balance leads to a bilayer whose structural organization cannot be ascribed to either a liquid ordered or to a canonical liquid disordered phase, in that it displays a very loose packing of the intermediate segments of lipid chains.


Subject(s)
Fatty Acids, Omega-3 , Lipid Bilayers , Cholesterol/chemistry , Lipid Bilayers/chemistry , Phospholipids/chemistry , Phosphorylcholine
3.
Soft Matter ; 17(34): 7914-7920, 2021 Sep 14.
Article in English | MEDLINE | ID: mdl-34373877

ABSTRACT

The hydrodynamic drag force on a spherical particle in shear flow near-wall is investigated using optical tweezers and microfluidics. Simple shear flow is applied using a microfluidic channel at different volumetric flow rates. The hydrodynamic drag force exerted on the particle is detected from the displacement of the trapped particle. The effect of the wall is obtained from the force balance of the trapping and hydrodynamic drag force employing the exact solution of the theoretical model using the lubrication theory for a sphere near the wall. Here, we report the experimentally obtained hydrodynamic drag force coefficient under the influence of shear flow. The drag correction factor increases with decreasing distance from the wall due to the effect of the wall surface. We found that the calculated hydrodynamic drag force coefficient is in quantitative comparison with the theoretical prediction for a shear flow past a sphere near-wall. This study provides a straightforward investigation of the effect of the shear flow on the hydrodynamic drag force coefficient on a particle near the wall. Furthermore, these pieces of information can be used in various applications, particularly in optimizing microfluidic designs for mixing and separations of particles or exploiting the formation of the concentration gradient of particles perpendicular to flow directions caused by the non-linear hydrodynamic interactions.

4.
Molecules ; 26(20)2021 Oct 11.
Article in English | MEDLINE | ID: mdl-34684714

ABSTRACT

Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125-2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (Opn, Dmp1, and Mepe) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration.


Subject(s)
Bone Regeneration/physiology , Carrageenan/pharmacology , Osteogenesis/drug effects , Animals , Bone Regeneration/drug effects , Carrageenan/metabolism , Cell Culture Techniques , Cell Differentiation/drug effects , Cell Line , Cell Proliferation/drug effects , Mice , Osteoblasts/drug effects , Osteoblasts/metabolism , Osteogenesis/physiology , Tissue Engineering/methods
5.
Angew Chem Int Ed Engl ; 60(42): 22812-22817, 2021 Oct 11.
Article in English | MEDLINE | ID: mdl-34379346

ABSTRACT

The introduction of "water-in-salt" electrolyte (WiSE) concept opens a new horizon to aqueous electrochemistry that is benefited from the formation of a solid-electrolyte interphase (SEI). However, such SEI still faces multiple challenges, including dissolution, mechanical damaging, and incessant reforming, which result in poor cycling stability. Here, we report a polymeric additive, polyacrylamide (PAM) that effectively stabilizes the interphase in WiSE. With the addition of 5 molar % PAM to 21 mol kg-1 LiTFSI electrolyte, a LiMn2 O4 ∥L-TiO2 full cell exhibits enhanced cycling stability with 86 % capacity retention after 100 cycles at 1 C. The formation mechanism and evolution of PAM-assisted SEI was investigated using operando small angle neutron scattering and density functional theory (DFT) calculations, which reveal that PAM minimizes the presence of free water molecules at the anode/electrolyte interface, accelerates the TFSI- anion decomposition, and densifies the SEI.

6.
Crit Care Med ; 48(1): e48-e57, 2020 01.
Article in English | MEDLINE | ID: mdl-31714400

ABSTRACT

OBJECTIVES: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to treatment delay. Our objective was to assess the host proteomic response to infection utilizing an aptamer-based multiplexed proteomics approach to identify novel serum protein changes that might help distinguish between pediatric sepsis and infection-negative systemic inflammation and hence can potentially improve sensitivity and specificity of the diagnosis of sepsis over current clinical criteria approaches. DESIGN: Retrospective, observational cohort study. SETTING: PICU and cardiac ICU, Seattle Children's Hospital, Seattle, WA. PATIENTS: A cohort of 40 children with clinically overt sepsis and 30 children immediately postcardiopulmonary bypass surgery (infection-negative systemic inflammation control subjects) was recruited. Children with sepsis had a confirmed or suspected infection, two or more systemic inflammatory response syndrome criteria, and at least cardiovascular and/or pulmonary organ dysfunction. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Serum samples from 35 of the sepsis and 28 of the bypass surgery subjects were available for screening with an aptamer-based proteomic platform that measures 1,305 proteins to search for large-scale serum protein expression pattern changes in sepsis. A total of 111 proteins were significantly differentially expressed between the sepsis and control groups, using the linear models for microarray data (linear modeling) and Boruta (decision trees) R packages, with 55 being previously identified in sepsis patients. Weighted gene correlation network analysis helped identify 76 proteins that correlated highly with clinical sepsis traits, 27 of which had not been previously reported in sepsis. CONCLUSIONS: The serum protein changes identified with the aptamer-based multiplexed proteomics approach used in this study can be useful to distinguish between sepsis and noninfectious systemic inflammation.


Subject(s)
Blood Proteins/analysis , Proteomics/methods , Sepsis/blood , Sepsis/diagnosis , Aptamers, Peptide , Child , Cohort Studies , Humans , Retrospective Studies , Sepsis/genetics
7.
Soft Matter ; 16(46): 10425-10438, 2020 Dec 14.
Article in English | MEDLINE | ID: mdl-33165495

ABSTRACT

Polyunsaturated omega-3 fatty acid docosahexaenoic acid (DHA) is found in very high concentrations in a few peculiar tissues, suggesting that it must have a specialized role. DHA was proposed to affect the function of the cell membrane and related proteins through an indirect mechanism of action, based on the DHA-phospholipid effects on the lipid bilayer structure. In this respect, most studies have focused on its influence on lipid-rafts, somehow neglecting the analysis of effects on liquid disordered phases that constitute most of the cell membranes, by reporting in these cases only a general fluidifying effect. In this study, by combining neutron reflectivity, cryo-transmission electron microscopy, small angle neutron scattering, dynamic light scattering and electron paramagnetic resonance spectroscopy, we characterize liquid disordered bilayers formed by the naturally abundant 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and different contents of a di-DHA glycero-phosphocholine, 22:6-22:6PC, from both a molecular/microscopic and supramolecular/mesoscopic viewpoint. We show that, below a threshold concentration of about 40% molar percent, incorporation of 22:6-22:6PC in the membrane increases the lipid dynamics slightly but sufficiently to promote the membrane deformation and increase of multilamellarity. Notably, beyond this threshold, 22:6-22:6PC disfavours the formation of lamellar phases, leading to a phase separation consisting mostly of small spherical particles that coexist with a minority portion of a lipid blob with water-filled cavities. Concurrently, from a molecular viewpoint, the polyunsaturated acyl chains tend to fold and expose the termini to the aqueous medium. We propose that this peculiar tendency is a key feature of the DHA-phospholipids making them able to modulate the local morphology of biomembranes.


Subject(s)
Fatty Acids, Omega-3 , Lipid Bilayers , Docosahexaenoic Acids , Membrane Microdomains , Phosphatidylcholines , Phospholipids
8.
Chemistry ; 25(19): 5014-5021, 2019 Apr 01.
Article in English | MEDLINE | ID: mdl-30682220

ABSTRACT

CH3 NH3 PbBr3 perovskite quantum dots (PQDs) are synthesized by using four different linear alkyl phosphonic acids (PAs) in conjunction with (3-aminopropyl)triethoxysilane (APTES) as capping ligands. The resultant PQDs are characterized by means of XRD, TEM, Raman spectroscopy, FTIR spectroscopy, UV/Vis, photoluminescence (PL), time-resolved PL, and X-ray photoelectron spectroscopy (XPS). PA chain length is shown to control the PQD size (ca. 2.9-4.2 nm) and excitonic absorption band positions (λ=488-525 nm), with shorter chain lengths corresponding to smaller sizes and bluer absorptions. All samples show a high PL quantum yield (ca. 46-83 %) and high PL stability; this is indicative of a low density of band gap trap states and effective surface passivation. Stability is higher for smaller PQDs; this is attributed to better passivation due to better solubility and less steric hindrance of the shorter PA ligands. Based on the FTIR, Raman, and XPS results, it is proposed that Pb2+ and CH3 NH3 + surface defects are passivated by R-PO3 2- or R-PO2 (OH)- , whereas Br- surface defects are passivated by R-NH3 + moieties. This study establishes the combination of PA and APTES ligands as a highly effective dual passivation system for the synergistic passivation of multiple surface defects of PQDs through primarily ionic bonding.

9.
Langmuir ; 35(43): 13904-13914, 2019 Oct 29.
Article in English | MEDLINE | ID: mdl-31566987

ABSTRACT

The self-assembly of the two anomeric forms of n-hexadecyl-d-maltopyranoside (denoted α-C16G2 and ß-C16G2) has been studied in dilute aqueous solution by means of surface tension measurements, scattering methods (dynamic light scattering, static light scattering, and small-angle X-ray and neutron scattering), and cryo-transmission electron microscopy at different surfactant concentrations and temperatures. Surface tension measurements demonstrate differences in the surfactant adsorption at the air-water interface, where α-C16G2 shows a lower CMC than ß-C16G2. Similarly, micelle morphology was found to profoundly depend on anomerism. ß-C16G2 preferentially forms very elongated micelles with large persistence lengths, whereas α-C16G2 assembles into smaller micelles for which the structure varies with concentration and temperature. The differences between the two surfactant anomers in terms of self-assembly can be attributed to the interaction between neighboring headgroups. Specifically, ß-C16G2 allows for a closer packing in the palisade layer, hence reducing the micelle curvature and promoting the formation of more elongated micelles. Strong intermolecular headgroup interactions may also account for the observed rigidity of the micelles.

10.
Langmuir ; 35(19): 6441-6452, 2019 May 14.
Article in English | MEDLINE | ID: mdl-31017439

ABSTRACT

Smart, fully orthogonal switching was realized in a highly biocompatible diblock copolymer system with variable trigger-induced aqueous self-assembly. The polymers are composed of nonionic and zwitterionic blocks featuring lower and upper critical solution temperatures (LCSTs and UCSTs). In the system investigated, diblock copolymers from poly( N-isopropyl methacrylamide) (PNIPMAM) and a poly(sulfobetaine methacrylamide), systematic variation of the molar mass of the latter block allowed for shifting the UCST of the latter above the LCST of the PNIPMAM block in a salt-free condition. Thus, successive thermal switching results in "schizophrenic" micellization, in which the roles of the hydrophobic core block and the hydrophilic shell block are interchanged depending on the temperature. Furthermore, by virtue of the strong electrolyte-sensitivity of the zwitterionic polysulfobetaine block, we succeeded to shift its UCST below the LCST of the PNIPMAM block by adding small amounts of an electrolyte, thus inverting the pathway of switching. This superimposed orthogonal switching by electrolyte addition enabled us to control the switching scenarios between the two types of micelles (i) via an insoluble state, if the LCST-type cloud point is below the UCST-type cloud point, which is the case at low salt concentrations or (ii) via a molecularly dissolved state, if the LCST-type cloud point is above the UCST-type cloud point, which is the case at high salt concentrations. Systematic variation of the block lengths allowed for verifying the anticipated behavior and identifying the molecular architecture needed. The versatile and tunable self-assembly offers manifold opportunities, for example, for smart emulsifiers or for sophisticated carrier systems.

11.
Proc Natl Acad Sci U S A ; 113(33): 9238-43, 2016 08 16.
Article in English | MEDLINE | ID: mdl-27482098

ABSTRACT

People often demand a greater price when selling goods that they own than they would pay to purchase the same goods-a well-known economic bias called the endowment effect. The endowment effect has been found to be muted among experienced traders, but little is known about how trading experience reduces the endowment effect. We show that when selling, experienced traders exhibit lower right anterior insula activity, but no differences in nucleus accumbens or orbitofrontal activation, compared with inexperienced traders. Furthermore, insula activation mediates the effect of experience on the endowment effect. Similar results are obtained for inexperienced traders who are incentivized to gain trading experience. This finding indicates that frequent trading likely mitigates the endowment effect indirectly by modifying negative affective responses in the context of selling.


Subject(s)
Cerebral Cortex/physiology , Consumer Behavior , Financial Management , Adult , Humans , Magnetic Resonance Imaging , Middle Aged , Nucleus Accumbens/physiology , Prefrontal Cortex/physiology
12.
J Vis ; 19(12): 14, 2019 10 01.
Article in English | MEDLINE | ID: mdl-31622473

ABSTRACT

Past research suggests that recognizing scene gist, a viewer's holistic semantic representation of a scene acquired within a single eye fixation, involves purely feed-forward mechanisms. We investigated whether expectations can influence scene categorization. To do this, we embedded target scenes in more ecologically valid, first-person-viewpoint image sequences, along spatiotemporally connected routes (e.g., an office to a parking lot). We manipulated the sequences' spatiotemporal coherence by presenting them either coherently or in random order. Participants identified the category of one target scene in a 10-scene-image rapid serial visual presentation. Categorization accuracy was greater for targets in coherent sequences. Accuracy was also greater for targets with more visually similar primes. In Experiment 2, we investigated whether targets in coherent sequences were more predictable and whether predictable images were identified more accurately in Experiment 1 after accounting for the effect of prime-to-target visual similarity. To do this, we removed targets and had participants predict the category of the missing scene. Images were more accurately predicted in coherent sequences, and both image predictability and prime-to-target visual similarity independently contributed to performance in Experiment 1. To test whether prediction-based facilitation effects were solely due to response bias, participants performed a two-alternative forced-choice task in which they indicated whether the target was an intact or a phase-randomized scene. Critically, predictability of the target category was irrelevant to this task. Nevertheless, results showed that sensitivity, but not response bias, was greater for targets in coherent sequences. Predictions made prior to viewing a scene facilitate scene-gist recognition.


Subject(s)
Fixation, Ocular , Pattern Recognition, Visual , Recognition, Psychology , Visual Perception , Adult , Attention , Female , Humans , Image Processing, Computer-Assisted , Male , Reaction Time , Vision, Ocular , Young Adult
13.
J Vis ; 19(5): 15, 2019 05 01.
Article in English | MEDLINE | ID: mdl-31100131

ABSTRACT

We investigated the relative contributions of central versus peripheral vision in scene-gist recognition with panoramic 180° scenes. Experiment 1 used the window/scotoma paradigm of Larson and Loschky (2009). We replicated their findings that peripheral vision was more important for rapid scene categorization, while central vision was more efficient, but those effects were greatly magnified. For example, in comparing our critical radius (which produced equivalent performance with mutually exclusive central and peripheral image regions) to that of Larson and Loschky, our critical radius of 10° had a ratio of central to peripheral image area that was 10 times smaller. Importantly, we found different functional relationships between the radius of centrally versus peripherally presented imagery (or the proportion of centrally versus peripherally presented image area) and scene-categorization sensitivity. For central vision, stimulus discriminability was an inverse function of image radius, while for peripheral vision the relationship was essentially linear. In Experiment 2, we tested the photographic-bias hypothesis that the greater efficiency of central vision for rapid scene categorization was due to more diagnostic information in the center of photographs. We factorially compared the effects of the eccentricity from which imagery was sampled versus the eccentricity at which imagery was presented. The presentation eccentricity effect was roughly 3 times greater than the sampling eccentricity effect, showing that the central-vision efficiency advantage was primarily due to the greater sensitivity of central vision. We discuss our results in terms of the eccentricity-dependent neurophysiology of vision and discuss implications for computationally modeling rapid scene categorization.


Subject(s)
Pattern Recognition, Visual/physiology , Recognition, Psychology/physiology , Visual Fields/physiology , Visual Perception/physiology , Adult , Female , Humans , Male , Visual Field Tests , Young Adult
14.
Clin Transplant ; 32(2)2018 02.
Article in English | MEDLINE | ID: mdl-29277952

ABSTRACT

BACKGROUND: In single ventricle patients, aortopulmonary collaterals (APCs) and pulmonary arteriovenous malformations (PAVMs) following superior cavopulmonary shunt (CPS) can complicate orthotopic heart transplant (OHT) by cyanosis and hemoptysis. Although PAVMs can regress with the restoration of hepatic venous flow to the pulmonary circulation, the effects of hypoxemia on the "unconditioned" allograft are not known. CASES: Two patients with significant PAVMs after CPS were cyanotic following OHT. One patient with predominantly unilateral left PAVMs had arterial saturation levels less than 70% despite pulmonary vasodilators and ventilation. A custom flow restrictor-covered stent was deployed in the pulmonary artery of the affected side, redirecting the blood flow to the contralateral lung, immediately improving cyanosis. When the PAVMs regressed, the flow restrictor stent was dilated to eliminate the constriction. The second patient with PAVMs had cyanosis and severe hemoptysis from APCs post-OHT. The APCs required an extensive coil embolization, while the cyanosis responded to oxygen and pulmonary vasodilators. Both recipients did well with gradual resolution of PAVMs within 8 months. CONCLUSIONS: Despite cyanosis from right-to-left intrapulmonary shunting, allograft function recovered. Novel transcatheter interventions can play a role in patients with significant APCs or PAVM following cardiac transplantation.


Subject(s)
Arteriovenous Fistula/therapy , Arteriovenous Malformations/therapy , Embolization, Therapeutic , Heart Transplantation , Pulmonary Artery/abnormalities , Pulmonary Veins/abnormalities , Female , Humans , Infant , Male , Prognosis , Pulmonary Circulation
15.
Pediatr Transplant ; 22(8): e13307, 2018 12.
Article in English | MEDLINE | ID: mdl-30338630

ABSTRACT

BACKGROUND: The hybrid stage 1 palliation for hypoplastic left heart syndrome (HLHS) was first described in 1993 as a bridge to heart transplant for HLHS. There are limited data on this strategy as primary heart transplantation for HLHS has become less common. METHODS: This is an observational, single-center study comparing pre- and post-transplant outcomes of patients listed for transplant following hybrid palliation with those following surgical stage 1 palliation. RESULTS: From 2004 to 2017, 21 patients underwent hybrid palliation as a bridge to heart transplant and 28 patients were listed for transplant following surgical stage 1 palliation or aortic arch repair and pulmonary artery band placement. Premature birth and the presence of genetic or anatomic abnormalities were more common in the hybrid group. Need for extracorporeal membrane oxygenation (ECMO) support and ventricular dysfunction was more common in the surgical group. There was a trend toward shorter waitlist times in the surgical cohort (36 days vs 70 days, P = 0.06). There was no difference in waitlist mortality (19% vs 21%, P = 0.61). Survival at 1 and 5 years post-transplant was similar for the hybrid and surgical cohorts (5-year survival, 80% vs 85%, P = 0.94, respectively). There was no difference in the number of post-transplant interventions. CONCLUSIONS: Although the hybrid patients represented a higher risk cohort and demonstrated longer wait times, the waitlist and post-transplant mortality was equivalent between the two groups. For high-risk patients, the hybrid palliation as a bridge to transplant appears to be a reasonable strategy.


Subject(s)
Heart Transplantation/methods , Heart Ventricles/physiopathology , Hypoplastic Left Heart Syndrome/surgery , Palliative Care/methods , Aorta, Thoracic/surgery , Cardiology/methods , Female , Heart Bypass, Right , Humans , Infant , Infant, Newborn , Male , Pulmonary Artery/surgery , Retrospective Studies , Risk , Treatment Outcome , Waiting Lists
16.
J Phys Chem A ; 2018 Aug 20.
Article in English | MEDLINE | ID: mdl-30125104

ABSTRACT

The Synthetic Biological Membrane (SBM) project at NASA Ames developed a portable, self-repairing wastewater purification system. The self-repair process relies upon secreted fatty acids from a genetically engineered organism. However, solubilized fatty acids are difficult to detect using conventional methods. Surface-enhanced Raman scattering (SERS) was used to successfully detect solubilized fatty acids with the following limits of detection: 10-9 M, 10-8 M, 10-9 M, and 10-6 M for decanoic acid, myristic acid, palmitic acid, and stearic acid, respectively. Additionally, hollow core photonic crystal fiber (HCPCF) was applied as the sampling device together with SERS to develop in situ surveillance of the production of fatty acids. Using SERS + HCPCF yielded an 18 fold enhancement in SERS signal for the CH2 twist peak at 1295 cm-1 as compared to SERS alone. The results will help the SBM project to integrate a self-healing wastewater purification membrane into future water recycling systems.

17.
Hum Factors ; 60(2): 236-247, 2018 03.
Article in English | MEDLINE | ID: mdl-29241017

ABSTRACT

Objective We implemented a gaze-contingent useful field of view paradigm to examine older adult multitasking performance in a simulated driving environment. Background Multitasking refers to the ability to manage multiple simultaneous streams of information. Recent work suggests that multitasking declines with age, yet the mechanisms supporting these declines are still debated. One possible framework to better understand this phenomenon is the useful field of view, or the area in the visual field where information can be attended and processed. In particular, the useful field of view allows for the discrimination of two competing theories of real-time multitasking, a general interference account and a tunneling account. Methods Twenty-five older adult subjects completed a useful field of view task that involved discriminating the orientation of lines in gaze-contingent Gabor patches appearing at varying eccentricities (based on distance from the fovea) as they operated a vehicle in a driving simulator. In half of the driving scenarios, subjects also completed an auditory two-back task to manipulate cognitive workload, and during some trials, wind was introduced as a means to alter general driving difficulty. Results Consistent with prior work, indices of driving performance were sensitive to both wind and workload. Interestingly, we also observed a decline in Gabor patch discrimination accuracy under high cognitive workload regardless of eccentricity, which provides support for a general interference account of multitasking. Conclusion The results showed that our gaze-contingent useful field of view paradigm was able to successfully examine older adult multitasking performance in a simulated driving environment. Application This study represents the first attempt to successfully measure dynamic changes in the useful field of view for older adults completing a multitasking scenario involving driving.


Subject(s)
Aging/physiology , Auditory Perception/physiology , Executive Function/physiology , Eye Movements/physiology , Pattern Recognition, Visual/physiology , Psychomotor Performance/physiology , Visual Fields/physiology , Aged , Automobile Driving , Humans
18.
J Chem Phys ; 146(4): 044106, 2017 01 28.
Article in English | MEDLINE | ID: mdl-28147517

ABSTRACT

Reaction-diffusion models are widely used to study spatially extended chemical reaction systems. In order to understand how the dynamics of a reaction-diffusion model are affected by changes in its input parameters, efficient methods for computing parametric sensitivities are required. In this work, we focus on the stochastic models of spatially extended chemical reaction systems that involve partitioning the computational domain into voxels. Parametric sensitivities are often calculated using Monte Carlo techniques that are typically computationally expensive; however, variance reduction techniques can decrease the number of Monte Carlo simulations required. By exploiting the characteristic dynamics of spatially extended reaction networks, we are able to adapt existing finite difference schemes to robustly estimate parametric sensitivities in a spatially extended network. We show that algorithmic performance depends on the dynamics of the given network and the choice of summary statistics. We then describe a hybrid technique that dynamically chooses the most appropriate simulation method for the network of interest. Our method is tested for functionality and accuracy in a range of different scenarios.

19.
Neuroimage ; 134: 295-304, 2016 07 01.
Article in English | MEDLINE | ID: mdl-27001497

ABSTRACT

Perceiving the visual world around us requires the brain to represent the features of stimuli and to categorize the stimulus based on these features. Incorrect categorization can result either from errors in visual representation or from errors in processes that lead to categorical choice. To understand the temporal relationship between the neural signatures of such systematic errors, we recorded whole-scalp magnetoencephalography (MEG) data from human subjects performing a rapid-scene categorization task. We built scene category decoders based on (1) spatiotemporally resolved neural activity, (2) spatial envelope (SpEn) image features, and (3) behavioral responses. Using confusion matrices, we tracked how well the pattern of errors from neural decoders could be explained by SpEn decoders and behavioral errors, over time and across cortical areas. Across the visual cortex and the medial temporal lobe, we found that both SpEn and behavioral errors explained unique variance in the errors of neural decoders. Critically, these effects were nearly simultaneous, and most prominent between 100 and 250ms after stimulus onset. Thus, during rapid-scene categorization, neural processes that ultimately result in behavioral categorization are simultaneous and co-localized with neural processes underlying visual information representation.


Subject(s)
Brain Mapping/methods , Cerebral Cortex/physiology , Magnetoencephalography/methods , Pattern Recognition, Visual/physiology , Recognition, Psychology/physiology , Task Performance and Analysis , Adult , Female , Humans , Male , Nerve Net/physiology , Reaction Time/physiology
20.
Nat Mater ; 14(4): 373-8, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25581627

ABSTRACT

The conduction electrons in a metal experience competing interactions with each other and the atomic nuclei. This competition can lead to many types of magnetic order in metals. For example, in chromium the electrons order to form a spin-density-wave (SDW) antiferromagnetic state. A magnetic field may be used to perturb or tune materials with delicately balanced electronic interactions. Here, we show that the application of a magnetic field can induce SDW magnetic order in a quasi-2D metamagnetic metal, where none exists in the absence of the field. We use magnetic neutron scattering to show that the application of a large (B ≈ 8 T) magnetic field to the perovskite metal Sr3Ru2O7 (refs 3-7) can be used to tune the material through two magnetically ordered SDW states. The ordered states exist over relatively small ranges in field (≲0.4 T), suggesting that their origin is due to a new mechanism related to the electronic fine structure near the Fermi energy, possibly combined with the stabilizing effect of magnetic fluctuations. The magnetic field direction is shown to control the SDW domain populations, which naturally explains the strong resistivity anisotropy or 'electronic nematic' behaviour observed in this material.

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