ABSTRACT
The biofilm formation by bacteria E. coli is a magnetosensitive process. The combined effects of a magnetic magnesium isotope 25Mg and a static magnetic field in the range of 20-35 mT stimulate biofilm formation by E. coli compared to nonmagnetic magnesium isotopes 24.26Mg. Magnetic field effects in the range of 2-10 mT, recorded for all bacteria regardless of the magnesium-isotope enrichment of the nutrient medium, indicate the sensitivity of intracellular processes to weak magnetic fields.
Subject(s)
Biofilms/growth & development , Escherichia coli/physiology , Magnesium/pharmacology , Magnetic Fields , Isotopes/pharmacologyABSTRACT
The combined effect of the zinc magnetic isotope 67Zn and weak magnetic field 25-35 mT causes a 2-4-fold increase in the colony-forming ability of bacteria E. coli in comparison with the nonmagnetic isotopes 64, 66Zn. The effects of magnetic field in the range of 2.2-8 mT were detected for all bacteria regardless of the zinc-isotope enrichment of the media. This indicates the sensitivity of intracellular processes to weak magnetic fields. An increase in the ATP concentration in E. coli cells was only detected for the bacteria grown on the medium with the magnetic zinc isotope in the range of 2.2-4.2 mT. The obtained data confirm the existence of stages of intracellular enzymatic processes that are sensitive to magnetic fields and magnetic moments of atomic nuclei.
Subject(s)
Escherichia coli/drug effects , Magnetic Fields , Zinc Isotopes/pharmacology , Adenosine Triphosphate/metabolism , Escherichia coli/cytology , Intracellular Space/drug effects , Intracellular Space/metabolismABSTRACT
The ATP pool in Escherichia coli is a magnetic-dependent characteristic of microorganism vital activity. It depends on the values of the external static magnetic field and the existence of magnetic moment of magnesium isotopes nuclei added to the growth nutrient medium. The combined effects of the magnetic field 70-95 mT and magnesium magnetic isotope 25Mg on E. coli bacteria leads to increase intracellular concentration of ATP. Magnetic-field effects in the range of 0.8-16 mT, registered for all bacteria regardless of the magnesium-isotopic enrichment of nutrient medium, evidence about the sensitivity of intracellular processes to weak magnetic fields.
Subject(s)
Adenosine Triphosphate/metabolism , Escherichia coli/metabolism , Magnetic Fields , Escherichia coli/cytology , Intracellular Space/metabolismABSTRACT
Effects of synergism and antagonism of antibacterial drugs and magnetic isotope of magnesium (25)Mg on antibiotic resistance of bacteria E. coli were discovered. Fourteen antibiotics from seven different groups were tested. The increase in antibiotic resistance in the presence of the ion (25)Mg(2+) was discovered in E. coli cells incubated with quinolones/fluoroquinolones, indicating the inhibiting effect of the magnetic moments of nuclei (25)Mg on DNA synthesis. The change in antibiotic resistance was also detected in bacteria affected by magnesium (25)Mg and certain antibiotics from aminoglycoside and lincosamide groups.