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Obesity (Silver Spring) ; 15(6): 1441-7, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17557981

ABSTRACT

OBJECTIVE: Excess abdominal adiposity is a known risk factor for cardiovascular diseases. Computed tomography can be used to examine the visceral (VAT) and subcutaneous (SAT) components of abdominal adiposity, but it is unresolved whether single-slice or multi-slice protocols are needed. RESEARCH METHOD AND PROCEDURES: Nine computed tomography scans were obtained in the lumbar spine region of 24 adults. The nine slices were obtained at three intervertebral positions (L2-L3, L3-L4, and L4-L5) and at 7 mm above and below these locations. Intra-site and inter-site differences in SAT, VAT, total adipose tissue, and the VAT/SAT ratio were examined using ANOVA and confidence intervals for pairwise differences between means. RESULTS: Intervertebral SAT values increased from 103.1 +/- 50.9 (standard deviation) cm(2) at L2-L3 to 153.3 +/- 68.8 cm(2) at L4-L5, whereas the corresponding VAT values decreased from 164.3 +/- 125.4 to 126.0 +/- 82.7 cm(2). The VAT/SAT ratio was not constant, decreasing from 1.8 +/- 1.4 to 0.9 +/- 0.7. Repeated-measures ANOVA indicated significant inter- and intra-site differences (p

Subject(s)
Adiposity , Anti-Retroviral Agents/therapeutic use , HIV Infections/drug therapy , Intra-Abdominal Fat/pathology , Subcutaneous Fat/pathology , Viscera , Adult , Female , HIV Infections/complications , HIV Infections/pathology , HIV-1 , HIV-Associated Lipodystrophy Syndrome/pathology , Humans , Male , Middle Aged , Organ Specificity
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