ABSTRACT
The core problem of phase diversity phase retrieval (PDPR) is to find suitable optimization algorithms for wave-front sensing of different scales, especially for large-scale wavefront sensing. When dealing with large-scale wave-front sensing, existing gradient-based local optimization algorithms used in PDPR are easily trapped in local minimums near initial positions, and available global optimization algorithms possess low convergence efficiency. We construct a practicable optimization algorithm used in PDPR for large-scale wave-front sensing. This algorithm, named EPSO-BFGS, is a two-step hybrid global optimization algorithm based on the combination of evolutionary particle swarm optimization (EPSO) and the Broyden-Fletcher-Goldfarb-Shanno (BFGS) algorithm. Firstly, EPSO provides global search and obtains a rough global minimum position in limited search steps. Then, BFGS initialized by the rough global minimum position approaches the global minimum with high accuracy and fast convergence speed. Numerical examples testify to the feasibility and reliability of EPSO-BFGS for wave-front sensing of different scales. Two numerical cases also validate the ability of EPSO-BFGS for large-scale wave-front sensing. The effectiveness of EPSO-BFGS is further affirmed by performing a verification experiment.
ABSTRACT
Myelin/oligodendrocyte specific protein (MOSP) is a recently characterized 48 kDa surface membrane protein that is expressed exclusively by oligodendrocytes in the CNS. In this report, evidence is presented for the identification of the stage in the oligodendrocyte lineage when MOSP is first expressed. MOSP initially appears on immature oligodendrocytes about four to five days postnatal, which is about one to two days after the appearance of galactocerebroside and sulfatide. The initial expression of MOSP occurs at the stage in development when oligodendrocytes are elaborating processes and just beginning to form membrane sheets. Since 1) MOSP is capable of signaling increases in microtubular structures in oligodendrocytes and 2) microtubular structures may be essential for extension of growing processes and the formation of membrane sheaths, MOSP may play an important role in differentiation of oligodendrocytes and the formation of myelin.