1.
Bioorg Med Chem Lett
; 18(1): 23-7, 2008 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-18054228
ABSTRACT
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles and significant but sub-optimal anticoagulant activities.