Are Omentin Rs2274907 and Vaspin Rs2236242 Gene Polymorphisms Related to Body Composition, Lipid Profile and Other Adipokines in Prepubertal Healthy Children?

Purpose/Aim: So far no research concerning the omentin-1 (ITLN1) rs2274907 and vaspin (SERPINA12) rs2236242 polymorphisms has been carried out in a healthy pediatric population. We analyzed associations of these polymorphisms with anthropometric parameters, lipid profile, as well as adiponectin, leptin and soluble leptin receptor (sOB-R) levels in prepubertal healthy children, to search for their possible role in the risk of obesity and obesity-related disorders.Materials and Methods: Frequencies of these polymorphisms were analyzed by the restriction fragment length polymorphism in 89 normal-weight children. The body composition was measured by dual-energy X-ray absorptiometry. Serum levels of adipokines were measured using ELISA methods.Results: We observed differences in values of HDL-cholesterol (p = 0.002) and triglycerides (p = 0.039) in children carrying different genotypes of the ITLN1 rs2274907 polymorphism. In children carrying different genotypes of the SERPINA12 rs2236242 polymorphism differences in BMI (p =0.025) and BMI Z-score (p = 0.01) values were found. Significant relations between anthropometric parameters and levels of HDL-cholesterol and triglycerides were associated with minor alleles of the studied polymorphisms. In addition, leptin/sOB-R ratio was related to HDL-cholesterol (p = 0.004) and triglycerides (p = 0.03) levels in children carrying minor allele of the SERPINA12 rs2236242 SNP.Conclusions: We suggest that both ITLN1 rs2274907 and SERPINA12 rs2236242 polymorphisms influence body composition and lipid profile in prepubertal healthy children. Relations between anthropometric parameters, lipid and adipokine levels may be associated with minor alleles of the studied polymorphisms. The possible role of these polymorphisms in the modulation of the risk of obesity and obesity-related disorders in the later life might be considered.

Scientific and organizational achievements of Professor of Anatomy Henryk Kadyi - Rector Vigilantissimus Universitatis Leopoliensis.

Henryk Kadyi (1851-1912) was educated in medicine at Jagiellonian and Vienna Universities, who deepened his studies in Leipzig to obtain associate professorship in descriptive anatomy at Alma Mater Cracoviensis, in 1878. He was elected Rector of Lvov University for years 1898-1899. Kadyi organized emerging Academy of Veterinary Medicine and Faculty of Medicine in Lvov. He equipped them with excellent anatomical facilities, e.g., remarkable collections of anatomical specimens. Kadyi worked out plans and such a detailed curriculum of higher studies in veterinary medicine, that it was raised to the ranks of academic discipline. He profoundly described accessory praehyoid and suprahyoid remnants of thyroid tissue and reasoned the anatomic term of arteria radicularis magna for artery of Adamkiewicz. Kadyi's social endeavors enabled women an access to higher education and university employment in 1895. His academic foresight, thrift and vigilance made Kadyi deserve a title of Rector Vigilantissimus.