ABSTRACT
In conditions of persisting high morbidity of COVID-19, issues related to prompt and timely medical care of population remains actual ones. The purpose of the study to analyze activities of the call-center of the Ministry of Health Care of the Udmurt Republic related to organization of medical care of COVID-19 patients in the Udmurt Republic. MATERIALS AND METHODS: The statistical (descriptive statistics) and descriptive methods were applied. The indicators of functioning of the call-center of the Ministry of Health Care of the Udmurt Republic in 2020-2022 were analyzed. The psychological characteristics of telephone counseling were studied. The satisfaction of medical organizations and citizens with services of call-center operators was assessed. THE RESULTS: The main principles of telephone counseling are confidentiality, maintenance of framework of working conversation, respect to personality of addressee. In 2020 the call center phone line received 34160 calls, in 2021 - 128339 calls, in 2022 - 65618 calls. In 25 months of operation the call-center operators received 228,117 calls from citizens related to issues of new coronavirus infection. The number of patient calls to the hot-line increases significantly when incidence of new coronavirus infection increases (r=0.885; p<0.05). Most frequently (25.1%) citizens contacted the call-center of the Ministry of Health Care of the Udmurt Republic due to inability to reach the polyclinic and on issues related to primary before-doctor care. The second place in terms of frequency (18.5%) took issues related to PCR-test results. The third place (14.1%) took issues related to duration of quarantine for patients and persons residing with them, possibility for children to attend preschool and educational institutions. The number of outgoing calling in 2020 was 16146, in 2021 - 89269 and in 2022 9936 calls. During 25 months of operation, call-center operators made 204,782 calls to citizens to monitor their health status and invite them to vaccinations and health screenings. More than half of outgoing calls (58.3%) were related to audio-monitoring of patients undergoing outpatient treatment with making-up of electronic protocol. CONCLUSIONS: During the period of increasing of COVID-19 morbidity, the call-center becomes an independent structural unit of organizing patient care. The medical organizations and citizens are satisfied with functioning of the call-center of the Ministry of Health Care of the Udmurt Republic organized in order of improving the organization of medical care of patients with COVID-19.
Subject(s)
COVID-19 , Call Centers , Child , Child, Preschool , Humans , COVID-19/epidemiology , Pandemics , Hotlines , CounselingABSTRACT
8-Oxoguanine-DNA N-glycosylase (OGG1) is a eukaryotic DNA repair enzyme responsible for the removal of 8-oxoguanine (oxoG), one of the most abundant oxidative DNA lesions. OGG1 catalyzes two successive reactions - N-glycosidic bond hydrolysis (glycosylase activity) and DNA strand cleavage on the 3'-side of the lesion by ß-elimination (lyase activity). The enzyme also exhibits lyase activity with substrates containing apurinic/apyrimidinic (AP) sites (deoxyribose moieties lacking the nucleobase). OGG1 is highly specific for the base opposite the lesion, efficiently excising oxoG and cleaving AP sites located opposite to C, but not opposite to A. The activity is also profoundly decreased by amino acid changes that sterically interfere with oxoG binding in the active site of the enzyme after the lesion is everted from the DNA duplex. Earlier, the molecular dynamics approach was used to study the conformational dynamics of such human OGG1 mutants in complexes with the oxoG:C-containing substrate DNA, and the population density of certain conformers of two OGG1 catalytic residues, Lys249 and Asp268, was suggested to determine the enzyme activity. Here, we report the study of molecular dynamics of human OGG1 bound to the oxoG:A-containing DNA and OGG1 mutants bound to the AP:C-containing DNA. We showed that the enzyme low activity is associated with a decrease in the populations of Lys249 and Asp268 properly configured for catalysis. The experimentally measured rate constants for the OGG1 mutants show a good agreement with the models. We conclude that the enzymatic activity of OGG1 is determined majorly by the population density of the catalytically competent conformations of the active site residues Lys249 and Asp268.
Subject(s)
Biocatalysis , DNA Glycosylases/metabolism , Catalytic Domain , DNA/chemistry , DNA/metabolism , DNA Glycosylases/chemistry , DNA Glycosylases/genetics , DNA Repair , Humans , Molecular Dynamics Simulation , Protein ConformationABSTRACT
AIM: The aim of the study is the analysis of risk factors, influencing on the progression of chronic obstructive pulmonary disease. MATERIALS AND METHODS: 259 patients with chronic obstructive pulmonary disease (COPD) I and III stages, mean age 54,3±11,7 and the duration of the disease 10,1±5,7. Patients were divided into 2 groups: I group (n=119) - with III stage of disease, II group (n=140) - COPD with I stage. 30 healthy were involved in control group. The risk factors of progression of COPD were determined with the use of regressive and correlative analyses. RESULTS: The level of markers of systemic inflammation in serum of patients with COPD: TNF-α (RR 3,25); IL-8 (RR 2,1); hs-CRP (RR 3,52) in combination with traditional risk factors (long course of the disease (RR 2,3), age (RR 1,65), smoking (RR 1,65), and also obesity (RR 2,45), early menopause (RR 3,52), hereditary respiratory predisposition (RR 3,05), and also coexisting cardiovascular pathology increase the risk of COPD progression several times. . CONCLUSION: According to the results of this trial, unmodified risk factors such as hereditary predisposition, early menopause, long course of the diseases and coexisting cardiovascular pathology contribute significantly on progression of COPD. The relative risk increases with increasing of concentration of markers of systemic inflammation (TNF-α, IL-8 and hs-CRP), that correlate with clinical manifestations of COPD: cough, shortness of breath on VAS in mm.
Subject(s)
Biomarkers , C-Reactive Protein , Inflammation , Pulmonary Disease, Chronic Obstructive , Adult , Biomarkers/analysis , Disease Progression , Female , Humans , Middle Aged , Pulmonary Disease, Chronic Obstructive/epidemiology , Pulmonary Disease, Chronic Obstructive/immunology , Risk FactorsABSTRACT
AIM: to analyze the efficacy of early detection of patients with mild acute pancreatitis. MATERIAL AND METHODS: 61 patients with acute pancreatitis who do not require intensive care were analyzed. Severity of condition was assessed using integral scales, i.e. modified index of severe pancreatitis severity (MITOP), BISAP, HAPS, SOFA, SIRS, CTSI and Atlanta classification (2012). RESULTS: Verification of mild course of disease according to MITOP scores ≤0.23 and BISAP scores ≤1 for the first 24 hours after admission and CTSI scores ≤3 within first 72 hours had high accuracy [AUC (CI 95%) 0.79 (0.66-0.91); 0.76 (0.66-0.87) and 0.99 (0.97-1.00) respectively], sensitivity and specificity (88.8 and 43.7%; 71.1 and 75.0%; 100 and 83.3% respectively). CONCLUSION: MITOP and BISAP scales are reliable to diagnose early mild acute pancreatitis. Their high positive diagnostic value (81.6 and 88.8%) allows to detect patients who do not require intensive care.
Subject(s)
Organ Dysfunction Scores , Pancreatitis , Acute Disease , Adult , Early Diagnosis , Female , Humans , Male , Middle Aged , Pancreatitis/diagnosis , Pancreatitis/etiology , Pancreatitis/physiopathology , Pancreatitis/therapy , Patient Selection , Prognosis , Reproducibility of Results , Severity of Illness IndexABSTRACT
Pulmonay thromboembolism is a common difficult-to-diagnose pathology not infrequently with a lethal outcome. There are many factors leading to hypercoagulation. One of them is intake of hormonal contraceptives to which doctors sometimes do not pay due attention. This paper reports two cases of acute coagulopathy with massive pulmonary thromboembolism in young women using these agents during a long period.
Subject(s)
Contraceptives, Oral, Hormonal/adverse effects , Pulmonary Embolism/chemically induced , Adult , Female , Global Health , Humans , Incidence , Pulmonary Embolism/epidemiology , Risk FactorsABSTRACT
The authors present results of treatment including laser radiation in patients with various occupational diseases. Evidence is that low-intensity laser radiation appears effective in occupational pathology. The treatment is based on blood circulation improvement.
Subject(s)
Blood Circulation/physiology , Low-Level Light Therapy/methods , Occupational Diseases/radiotherapy , HumansABSTRACT
In patients of young age atical clinical course of community-acquired pneumonia may mask of interstitial lung disease causing systemic vasculitis. Lung damage occurs in the form of vasculitis with perivascular infiltration, interstitial pneumonia symptoms and various sequential processes up to necrosis of the lung tissue and pleurisy. A distinctive feature of vascular pneumonia is probability of development of plurivisceral damage with simultaneous involvement of heart, kidney, abdominal, skin, joints and hepatolienal syndromes into tfe pathohogical process. At suspicion on development of systemic vasculitis it requires to perform differential diagnosis with the use of immunological tests and X-ray examination of the chest. Lung disease in systemic vasculitis worsens prognosis and necessitates urgent therapeutic measures.
Subject(s)
Kidney Diseases/diagnosis , Lung Diseases/diagnosis , Pneumonia, Bacterial/diagnosis , Systemic Vasculitis/diagnosis , Community-Acquired Infections/diagnosis , Diagnosis, Differential , Humans , Kidney Diseases/therapy , Lung Diseases/therapy , Male , Military Personnel , Pneumonia, Bacterial/therapy , Syndrome , Systemic Vasculitis/therapy , Young AdultABSTRACT
Inflammatory arthritis is accompanied by disorganization of the circadian rhythm of locomotion in rats. Control saline injections increased the rhythm disturbances. Chronic administration of melatonin (5 mg/kg) attenuated these chronopathological shifts. Diclofenac demonstrated much lower positive chronopharmacological activity than did melatonin.
Subject(s)
Arthritis, Experimental/physiopathology , Circadian Rhythm/drug effects , Diclofenac/pharmacology , Melatonin/pharmacology , Motor Activity/drug effects , Animals , Animals, Outbred Strains , Arthritis, Experimental/chemically induced , Behavior, Animal/drug effects , Circadian Rhythm/physiology , Formaldehyde , Injections, Intraperitoneal , Light , Male , Rats , Sodium Chloride/pharmacologyABSTRACT
In this paper we present results of a comprehensive analysis of the effect of heat shock at different stages of ontogenesis (adult stage, development of the mushroom bodies and the central complex) on courtship behavior (latency, duration and efficacy of courtship), sound production (pulse interval, dispersion of interpulse interval, the percentage of distorted pulses, the mean duration of the pulse parcels), learning and memory formation compared with the content of isoforms LIMK1 in Drosophila melanogaster male with altered structure of the limk1 gene. The heat shock is shown to affect the behavior parameters and LIMK1 content in analyzed strains of Drosophila. The most pronounced effect of the heat shock was observed at the stage of development of the central complex (CC). Heat shock at CC and adult restores the ability of learning and memory formation in the mutant strain agn(ts3), which normally is not able to learn and form memory. Correlations between changes of content of isoforms LIMK1 and behavioral parameters due to heat shock have not been established.
Subject(s)
Brain/metabolism , Drosophila Proteins/metabolism , Drosophila melanogaster/physiology , Heat-Shock Response , Lim Kinases/metabolism , Animals , Brain/growth & development , Brain/physiology , Drosophila Proteins/genetics , Drosophila melanogaster/genetics , Drosophila melanogaster/growth & development , Learning , Lim Kinases/genetics , Male , Memory , Mushroom Bodies/growth & development , Mushroom Bodies/metabolism , Mushroom Bodies/physiology , Protein Isoforms/genetics , Protein Isoforms/metabolism , Sexual Behavior, Animal , Vocalization, AnimalABSTRACT
Upper extremities occupational diseases resulting from physical overstrain are widely spread types of occupational pathology. The most common disease is myofibrosis. Seen nowadays, significant use of manual work in physical labour occupations cause high level of occupational morbidity due to physical overstrain. Review of previous studies showed that in spite of topicality the problem still lacks attention. Therefore the use of modern methods of occupational myofibrosis diagnosis such as contrast myography and ultrasound study, development of early diagnostic criteria, more accurate determination of severity degree and the process dynamics gets growing social and priority importance.
Subject(s)
Muscle, Skeletal/pathology , Muscular Diseases , Occupational Diseases , Occupational Exposure , Upper Extremity/pathology , Early Diagnosis , Fibrosis/pathology , Humans , Muscular Diseases/diagnosis , Muscular Diseases/etiology , Muscular Diseases/physiopathology , Myography/methods , Occupational Diseases/diagnosis , Occupational Diseases/etiology , Occupational Diseases/physiopathology , Occupational Exposure/adverse effects , Occupational Exposure/analysis , Occupational Exposure/prevention & control , Ultrasonography/methodsABSTRACT
Combination with a low dose of pineal hormone melatonin increased the anxiolytic effect of tofisopam (subthreshold dose) in open-field and cross-maze tests, as well as its chronotropic activity in time-course of forced swimming test in rats.
Subject(s)
Antidepressive Agents , Benzodiazepines , Central Nervous System Depressants , Maze Learning/drug effects , Melatonin , Animals , Antidepressive Agents/agonists , Antidepressive Agents/pharmacology , Benzodiazepines/agonists , Benzodiazepines/pharmacology , Central Nervous System Depressants/agonists , Central Nervous System Depressants/pharmacology , Drug Agonism , Male , Melatonin/agonists , Melatonin/pharmacology , Pineal Gland/metabolism , RatsABSTRACT
Occupational chronic myofibrosis is a disease resulting from physical overstrain and functional overload of upper extremities and shoulder girdle and beeing the most prevalent occupational diseases related to the so-called "working hand". Myofibrosis occur among persons employed actually in all industries, building and agriculture and may develop as an isolated disease or combined with other occupational diseases of musculoskeletal and peripheral nervous systems. Today problems of diagnostics, especially at the early stage of the disease, and the development of knew methods of treatment are still topical.
Subject(s)
Myositis/physiopathology , Occupational Diseases/physiopathology , Chronic Disease , Early Diagnosis , Fibrosis , Humans , Myositis/diagnosis , Myositis/therapy , Occupational Diseases/diagnosis , Occupational Diseases/therapyABSTRACT
Results of preventive measures introduction in 524 PC users, 98 jewelry polishers and 64 metallic ship hull assemblers are given. The use of preventive measures, based on low-intensity laser radiation, was shown to prevent development of visual overfatigue and occupational musculoskeletal system diseases.
Subject(s)
Fatigue/etiology , Low-Level Light Therapy/methods , Musculoskeletal Diseases/prevention & control , Occupational Diseases/prevention & control , Adult , Fatigue/prevention & control , Humans , Middle Aged , Musculoskeletal Diseases/etiology , Young AdultABSTRACT
A rise in the incidence of latent and late forms of neuro- and visceral syphilis significantly complicates diagnostics of the disease in patients admitted to emergency medicine clinics. Syphilis is believed to be a cause of roughly 0.5% of all cardiopathies. Late syphilitic lesions of the cardiovascular system (cardiovascular syphilis) occur in 0.25-0.96% patients in need of therapeutic treatment, 93.4% of them present with mesaortitis but its life-time diagnosis is possible only in 10% of the cases. Syphilitic lesions in the aorta are especially well apparent at the points of its branching into coronary arteries of the heart and aortic arch. One of the main consequences of syphilitic aortitis is the narrowing of coronary arteries frequently complicated by atherosclerosis, coronary thrombosis, and the resulting myocardial infarction. Another severe complication of syphilitic aortitis is progressive aortic valve insufficiency (in 25-50% of the patients) related to dilatation of the valve ring affected by inflammation. Some patients develop bacterial endocarditis of the aortic valve. Close localization of the coronary artery junction and the aortic valve account for a combination of aortic valve insufficiency and coronary insufficiency in patients with syphilitic process in the initial part of aorta. A case report is presented.
Subject(s)
Aortitis/diagnosis , Syphilis, Cardiovascular/diagnosis , Adult , Diagnosis, Differential , Humans , Myocardial Infarction/diagnosis , RussiaABSTRACT
Syndrome of Giyena-Barre can arise up in any age, in different regions, for men more frequent, than for women. There are descriptions of clinical supervisions of syndrome in domestic literature, combining with the defeat of the nervous system as a result of different pathogens which are procatarxiss in the start of mechanisms of immune attack on the albumens of mielina. However this disease continues to remain one of most heavy, requiring neyroreanimacionnykh measures, that causes the necessity of development of new methods of treatment in same queue.
Subject(s)
Guillain-Barre Syndrome/diagnosis , Guillain-Barre Syndrome/therapy , Adult , Critical Care , Electromyography , Female , Humans , Neurologic Examination , Plasmapheresis , Respiration, Artificial , Treatment OutcomeABSTRACT
The problem of cardiovascular disease and cancer, the effects of traumatic brain injury is now one of the major health and social problems. Every year in Ukraine registered 200 thousand cases of the victims of traumatic brain injury. Of these, 30% of people then have persistent signs of disability that results in a disability, sometimes painful existence the patient and his relatives. Therefore, in order to bring man back into society after a traumatic brain injury, to the rehabilitation phase of treatment, immediately after the stabilization of the patient.
Subject(s)
Brain Injuries/diagnosis , Brain Injuries/rehabilitation , Head Injuries, Closed/diagnosis , Head Injuries, Closed/rehabilitation , Head Injuries, Penetrating/diagnosis , Head Injuries, Penetrating/rehabilitation , Brain Injuries/drug therapy , Combined Modality Therapy , Drug Therapy, Combination , Electroencephalography , Head Injuries, Closed/drug therapy , Head Injuries, Penetrating/drug therapy , Humans , Magnetic Resonance Imaging , Male , Neuropsychological Tests , Physical Therapy Modalities , Reflexotherapy/methods , Time Factors , Treatment OutcomeABSTRACT
Acute ischemic brain injury (stroke, stroke), a leader among the causes of morbidity and mortality in the world. This pathology is one of the most pressing health and social problems that cause enormous economic damage to society, due to the high fatality rate, significant disability and social maladjustment of patients, which is based in most cases are the motor and cognitive impairment. Despite the fact that, currently established risk factors and pathophysiological basis of this disease, the availability of effective methods of diagnosing illness, still a practicing neurologist in some cases difficult to find adequate therapy that could effectively reach a well-established neurological deficit. Therefore the search for treatments that effectively reduce the health and social consequences of vascular damage to the brain, is one of the priority areas of neurology.
Subject(s)
Stroke Rehabilitation , Activities of Daily Living , Humans , Motor Activity/physiology , Rehabilitation/economics , Rehabilitation/methods , Rehabilitation/psychology , Socioeconomic Factors , Stroke/economics , Stroke/psychology , Time FactorsABSTRACT
The examination was applied to 598 patients with polytrauma and patients after surgery on bones and joints on the subject of various diseases of locomotor apparatus. All patients were tested on fat embolism in blood serum and cerebrospinal fluid. The modificated Guard's technique was applied. The test data permitted to develop the method of express diagnostics of oil embolism. It is established that fat liquorglobulia is a pathognomonic symptom of cerebral form of fat embolism.
Subject(s)
Embolism, Fat/blood , Embolism, Fat/cerebrospinal fluid , Embolism, Fat/etiology , Humans , Multiple Trauma/complicationsABSTRACT
In this paper, an exact three-dimensional transparent boundary condition for the parabolic wave equation in a rectangular computational domain is reported. It is a generalization of the well-known two-dimensional Basakov-Popov-Papadakis transparent boundary condition. It relates the boundary transversal derivative of the wave field at any given longitudinal position to the field values at all preceding computational steps. Several examples demonstrate propagation of light along simple structured optical fibers as well as in x-ray guiding structures. The proposed condition is simple and robust and can help to reduce the size of the computational domain considerably.
ABSTRACT
The suprachiasmatic nucleus is the primary circadian pacemaker in mammals. In turn, the suprachiasmatic nucleus influences circadian physiology, endocrinology and behavior via the synchronization of local oscillators that are operative in the cells of most organs and tissues. Thus circadian pacemaker may play an important role in psychiatric disorders and in psychotherapeutic drugs effect. In this review, we summarize data about the suprachiasmatic nuclei anatomy, physiology and pharmacological sensitivity.