ABSTRACT
Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective µ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.
Subject(s)
Myocardial Reperfusion Injury/metabolism , Receptors, Opioid/physiology , Analgesics, Opioid/pharmacology , Animals , Cardiotonic Agents/pharmacology , Disease Resistance , Heart Rate , Male , Myocardium/pathology , Narcotic Antagonists/pharmacology , Peptide Fragments/pharmacology , Peptide Fragments/physiology , Protective Factors , Rats, Wistar , Somatostatin/pharmacology , Somatostatin/physiologyABSTRACT
Intrauterine Candida albicans infection in mouse fetuses affected the type of granulomatous inflammation induced by BCG vaccine during the postnatal period. It manifested in increased formation of granulomas and variations in their cellular composition.
Subject(s)
Candida albicans , Candidiasis/immunology , Granuloma/immunology , Liver Diseases/immunology , Phagocytes/immunology , Tuberculosis/immunology , Animals , BCG Vaccine/toxicity , Candidiasis/complications , Disease Models, Animal , Female , Granuloma/microbiology , Liver Diseases/microbiology , Mice , Monocytes/immunology , Pregnancy , Prenatal Injuries/immunology , Prenatal Injuries/microbiology , Tuberculosis/complications , Uterus/microbiologyABSTRACT
Genetically determined peculiarities of the reaction of the mononuclear phagocyte system to BCG vaccine manifested in CBA and C57Bl/6 mice by differences in the number and size of granulomas and time course of changes in the cellular composition of granulomas, peripheral blood, and bone marrow.
Subject(s)
Leukocytes, Mononuclear/physiology , Phagocytes/physiology , Phagocytosis , Animals , Bone Marrow Cells/metabolism , Disease Models, Animal , Granulocytes/metabolism , Granuloma/metabolism , Leukocytes, Mononuclear/microbiology , Macrophages/metabolism , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Models, Biological , Neurons/metabolism , Phagocytes/microbiology , Phenotype , Species Specificity , Tuberculosis/pathologyABSTRACT
Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.