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1.

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics.

Bumbaca Yadav, Daniela; Sharma, Vikas K; Boswell, Charles Andrew; Hotzel, Isidro; Tesar, Devin; Shang, Yonglei; Ying, Yong; Fischer, Saloumeh K; Grogan, Jane L; Chiang, Eugene Y; Urban, Konnie; Ulufatu, Sheila; Khawli, Leslie A; Prabhu, Saileta; Joseph, Sean; Kelley, Robert F.

J Biol Chem ; 290(50): 29732-41, 2015 Dec 11.

Article in English | MEDLINE | ID: mdl-26491012

2.

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys.

Lu, Dan; Jin, Jin Yan; Girish, Sandhya; Agarwal, Priya; Li, Dongwei; Prabhu, Saileta; Dere, Randall C; Saad, Ola M; Nazzal, Denise; Koppada, Neelima; Ramanujan, Saroja; Ng, Chee M.

Pharm Res ; 32(6): 1907-19, 2015 Jun.

Article in English | MEDLINE | ID: mdl-25467958

3.

Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues.

Boswell, C Andrew; Mundo, Eduardo E; Ulufatu, Sheila; Bumbaca, Daniela; Cahaya, Hendry S; Majidy, Nicholas; Van Hoy, Marjie; Schweiger, Michelle G; Fielder, Paul J; Prabhu, Saileta; Khawli, Leslie A.

Mol Pharm ; 11(5): 1591-8, 2014 May 05.

Article in English | MEDLINE | ID: mdl-24702191

4.

Subcutaneous Administration of Monoclonal Antibodies: Pharmacology, Delivery, Immunogenicity, and Learnings From Applications to Clinical Development.

Davis, John D; Bravo Padros, Marçal; Conrado, Daniela J; Ganguly, Samit; Guan, Xiaowen; Hassan, Hazem E; Hazra, Anasuya; Irvin, Susan C; Jayachandran, Priya; Kosloski, Matthew P; Lin, Kuan-Ju; Mukherjee, Kamalika; Paccaly, Anne; Papachristos, Apostolos; Partridge, Michael A; Prabhu, Saileta; Visich, Jennifer; Welf, Erik S; Xu, Xiaoying; Zhao, An; Zhu, Min.

Clin Pharmacol Ther ; 115(3): 422-439, 2024 03.

Article in English | MEDLINE | ID: mdl-38093583

5.

Vascular physiology and protein disposition in a preclinical model of neurodegeneration.

Boswell, C Andrew; Mundo, Eduardo E; Johnstone, Bernadette; Ulufatu, Sheila; Schweiger, Michelle G; Bumbaca, Daniela; Fielder, Paul J; Prabhu, Saileta; Khawli, Leslie A.

Mol Pharm ; 10(5): 1514-21, 2013 May 06.

Article in English | MEDLINE | ID: mdl-23383983

6.

Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.

Zhong, Min; Hanan, Emily J; Shen, Wang; Bui, Minna; Arkin, Michelle R; Barr, Kenneth J; Evanchik, Marc J; Hoch, Ute; Hyde, Jennifer; Martell, Jose R; Oslob, Johan D; Paulvannan, Kumar; Prabhu, Saileta; Silverman, Jeffrey A; Wright, Jasmin; Yu, Chul H; Zhu, Jiang; Flanagan, W Mike.

Bioorg Med Chem Lett ; 21(1): 307-10, 2011 Jan 01.

Article in English | MEDLINE | ID: mdl-21109434

7.

Introduction to the theme 'technology - translational pharmacology'.

Prabhu, Saileta.

Drug Discov Today Technol ; 21-22: 1-2, 2016.

Article in English | MEDLINE | ID: mdl-27978981

8.

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity.

Khojasteh, Siamak Cyrus; Prabhu, Saileta; Kenny, Jane R; Halladay, Jason S; Lu, Anthony Y H.

Eur J Drug Metab Pharmacokinet ; 36(1): 1-16, 2011 Mar.

Article in English | MEDLINE | ID: mdl-21336516

9.

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.

Deng, Rong; Loyet, Kelly M; Lien, Samantha; Iyer, Suhasini; DeForge, Laura E; Theil, Frank-Peter; Lowman, Henry B; Fielder, Paul J; Prabhu, Saileta.

Drug Metab Dispos ; 38(4): 600-5, 2010 Apr.

Article in English | MEDLINE | ID: mdl-20071453

10.

Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.

Zhong, Min; Shen, Wang; Barr, Kenneth J; Arbitrario, Jennifer P; Arkin, Michelle R; Bui, Minna; Chen, Teresa; Cunningham, Brian C; Evanchik, Marc J; Hanan, Emily J; Hoch, Ute; Huen, Karen; Hyde, Jennifer; Kumer, Jeffery L; Lac, Teresa; Lawrence, Chris E; Martell, Jose R; Oslob, Johan D; Paulvannan, Kumar; Prabhu, Saileta; Silverman, Jeffrey A; Wright, Jasmin; Yu, Chul H; Zhu, Jiang; Flanagan, W Mike.

Bioorg Med Chem Lett ; 20(17): 5269-73, 2010 Sep 01.

Article in English | MEDLINE | ID: mdl-20655213

11.

Pharmacokinetic and Pharmacodynamic Considerations in the Design of Therapeutic Antibodies.

Leipold, Douglas; Prabhu, Saileta.

Clin Transl Sci ; 12(2): 130-139, 2019 03.

Article in English | MEDLINE | ID: mdl-30414357

12.

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules.

Crowell, Susan R; Wang, Kathryn; Famili, Amin; Shatz, Whitney; Loyet, Kelly M; Chang, Vincent; Liu, Yanqiu; Prabhu, Saileta; Kamath, Amrita V; Kelley, Robert F.

Transl Vis Sci Technol ; 8(6): 1, 2019 Nov.

Article in English | MEDLINE | ID: mdl-31695962

13.

Prediction of Human Pharmacokinetics of Antibody-Drug Conjugates From Nonclinical Data.

Li, Chunze; Zhang, Cindy; Deng, Rong; Leipold, Douglas; Li, Dongwei; Latifi, Brandon; Gao, Yuying; Zhang, Crystal; Li, Zao; Miles, Dale; Chen, Shang-Chiung; Samineni, Divya; Wang, Bei; Agarwal, Priya; Lu, Dan; Prabhu, Saileta; Girish, Sandhya; Kamath, Amrita V.

Clin Transl Sci ; 12(5): 534-544, 2019 09.

Article in English | MEDLINE | ID: mdl-31115997

14.

Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin.

Li, Dongwei; Lee, Donna; Dere, Randall C; Zheng, Bing; Yu, Shang-Fan; Fuh, Franklin K; Kozak, Katherine R; Chung, Shan; Bumbaca Yadav, Daniela; Nazzal, Denise; Danilenko, Dimitry; Go, Mary Ann T; Williams, Marna; Polson, Andrew G; Poon, Kirsten Achilles; Prabhu, Saileta.

Br J Pharmacol ; 176(19): 3805-3818, 2019 10.

Article in English | MEDLINE | ID: mdl-31270798

15.

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.

Chung, Shan; Nguyen, Van; Lin, Yuwen Linda; Lafrance-Vanasse, Julien; Scales, Suzie J; Lin, Kevin; Deng, Rong; Williams, Kathi; Sperinde, Gizette; Li, Juan Jenny; Zheng, Kai; Sukumaran, Siddharth; Tesar, Devin; Ernst, James A; Fischer, Saloumeh; Lazar, Greg A; Prabhu, Saileta; Song, An.

MAbs ; 11(5): 942-955, 2019 07.

Article in English | MEDLINE | ID: mdl-30982394

16.

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties.

Ovacik, Ayse Meric; Li, Ji; Lemper, Marie; Danilenko, Dimitry; Stagg, Nicola; Mathieu, Mary; Ellerman, Diego; Gupta, Vinita; Kalia, Navdeep; Nguy, Trung; Plaks, Vicki; David Johnson, Clarissa; Wang, Weiru; Brumm, Jochen; Fine, Bernard; Junttila, Teemu; Lin, Kedan; Carter, Paul J; Prabhu, Saileta; Spiess, Christoph; Kamath, Amrita V.

MAbs ; 11(2): 422-433, 2019.

Article in English | MEDLINE | ID: mdl-30550367

17.

Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination.

Stephan, Jean-Philippe; Chan, Pamela; Lee, Chien; Nelson, Christopher; Elliott, James Michael; Bechtel, Charity; Raab, Helga; Xie, David; Akutagawa, Jon; Baudys, Jakub; Saad, Ola; Prabhu, Saileta; Wong, Wai Lee T; Vandlen, Richard; Jacobson, Fred; Ebens, Allen.

Bioconjug Chem ; 19(8): 1673-83, 2008 Aug.

Article in English | MEDLINE | ID: mdl-18637680

18.

Drug delivery across the blood-brain barrier.

Khawli, Leslie A; Prabhu, Saileta.

Mol Pharm ; 10(5): 1471-2, 2013 May 06.

Article in English | MEDLINE | ID: mdl-23641922

19.

Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology.

Mandikian, Danielle; Figueroa, Isabel; Oldendorp, Amy; Rafidi, Hanine; Ulufatu, Sheila; Schweiger, Michelle G; Couch, Jessica A; Dybdal, Noel; Joseph, Sean B; Prabhu, Saileta; Ferl, Gregory Z; Boswell, C Andrew.

AAPS J ; 20(6): 107, 2018 10 08.

Article in English | MEDLINE | ID: mdl-30298434

20.

Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging.

Mandikian, Danielle; Rafidi, Hanine; Adhikari, Pragya; Venkatraman, Priya; Nazarova, Lidia; Fung, Gabriel; Figueroa, Isabel; Ferl, Gregory Z; Ulufatu, Sheila; Ho, Jason; McCaughey, Cynthia; Lau, Jeffrey; Yu, Shang-Fan; Prabhu, Saileta; Sadowsky, Jack; Boswell, C Andrew.

MAbs ; 10(8): 1269-1280, 2018.

Article in English | MEDLINE | ID: mdl-30199303

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