1.
J Am Chem Soc
; 136(30): 10589-92, 2014 Jul 30.
Article
in English
| MEDLINE
| ID: mdl-25017004
ABSTRACT
A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.