ABSTRACT
Toxic strains of the finely filamentous, velvety, dark-olive green to black algal organism, Microcolus Lyngbyaceus, (formerly Lyngbya majuscula Gomont, or "lyngbya") have been recognized as etiologic agent of "stinging seaweed" dermatitis (one of several forms of "swimmer's itch") in Hawaii since the late 1950s as reviewed. Lymphadenopathy, pustular folliculitus, and local infections have been reported in some persons.
Subject(s)
Dermatitis, Contact/etiology , Seaweed , Vibrio/isolation & purification , Water Microbiology , Cyanobacteria , Dermatitis, Contact/microbiology , Disease Outbreaks , Humans , Lyngbya Toxins/adverse effectsSubject(s)
Nervous System Diseases/etiology , Sympathetic Nervous System , Tetanus/complications , Aged , Blood Pressure/drug effects , Central Venous Pressure/drug effects , Curare/administration & dosage , Electric Stimulation , Heart Rate/drug effects , Humans , Hypertension/drug therapy , Hypertension/etiology , Injections, Intravenous , Male , Positive-Pressure Respiration , Propranolol/administration & dosage , Tachycardia/drug therapy , Tachycardia/etiology , Tetanus/therapy , Tracheotomy , Trimethaphan/administration & dosage , Ulnar NerveSubject(s)
Animals, Poisonous , Fishes, Poisonous , Plant Poisoning/therapy , Poisoning/therapy , Animals , HumansSubject(s)
Ambulances , Emergencies , Respiration Disorders/therapy , Hawaii , Humans , Respiration Disorders/epidemiologySubject(s)
Dermatitis, Contact/etiology , Porifera , Aged , Animals , Dermatitis, Contact/drug therapy , Dermatitis, Contact/pathology , Diagnosis, Differential , Female , Hawaii , HumansSubject(s)
Ciguatera Poisoning , Fishes, Poisonous , Foodborne Diseases/epidemiology , Marine Toxins/poisoning , Adolescent , Adult , Animals , Child , Child, Preschool , Disease Outbreaks/epidemiology , Female , Hawaii , Humans , Infant , Male , Middle AgedSubject(s)
Fishes, Poisonous , Foodborne Diseases/etiology , Aged , Animals , Hawaii , Humans , MaleSubject(s)
Ambulances , Emergency Medical Services , Hawaii , Heart Diseases/mortality , Humans , Wounds and Injuries/mortalityABSTRACT
Lethal 3 malignant brain tumor 1 (L3MBTL1), a homolog of the Drosophila polycomb tumor suppressor l(3)mbt, contains three tandem MBT repeats (3xMBT) that are critical for transcriptional repression. We recently reported that the 3xMBT repeats interact with mono- and dimethylated lysines in the amino termini of histones H4 and H1b to promote methylation-dependent chromatin compaction. Using a series of histone peptides, we now show that the recognition of mono- and dimethylated lysines in histones H3, H4 and H1.4 (but not their trimethylated or unmodified counterparts) by 3xMBT occurs in the context of a basic environment, requiring a conserved aspartic acid (D355) in the second MBT repeat. Despite the broad range of in vitro binding, the chromatin association of L3MBTL1 mirrors the progressive accumulation of H4K20 monomethylation during the cell cycle. Furthermore, transcriptional repression by L3MBTL1 is enhanced by the H4K20 monomethyltransferase PR-SET7 (to which it binds) but not SUV420H1 (an H4K20 trimethylase) or G9a (an H3K9 dimethylase) and knockdown of PR-SET7 decreases H4K20me1 levels and the chromatin association of L3MBTL1. Our studies identify the importance of H4K20 monomethylation and of PR-SET7 for L3MBTL1 function.