Motor-cortical oscillations in early stages of Parkinson's disease.

Pathophysiological changes in basal ganglia-thalamo-cortical circuits are well established in idiopathic Parkinson's disease (PD). However, it remains open whether such alterations already occur at early stages representing a characteristic neurophysiological marker of PD. Therefore, the present study aims at elucidating changes of synchronised oscillatory activity in early PD patients. In this study, we performed whole-head magnetoencephalography (MEG) in a resting condition and during steady state contraction of the more severely affected forearm in 10 drug­naive, de novo patients, in 10 early-stage patients with chronic medication and in 10 age-matched control subjects. While cortico-muscular coherence (CMC) did not differ between groups, patients showed increased sensori-motor cortical power at beta frequency (13­30 Hz) during rest as well as during isometric contraction compared to controls. In healthy control subjects the power of the contralateral hemisphere was significantly suppressed during isometric contraction. By contrast, both hemispheres were activated equally strongly in de novo patients. In medicated patients, the pattern was found to be reversed. Contralateral beta power was significantly correlated with motor impairment during isometric contraction but not during rest. The present results suggest that the reduced ability of the primary motor cortex to disengage from increased beta band oscillations during the execution of movements is an early marker of PD.

Effects of 10 Hz and 20 Hz transcranial alternating current stimulation (tACS) on motor functions and motor cortical excitability.

Synchronized oscillatory activity at alpha (8-12 Hz) and beta (13-30 Hz) frequencies plays a key role in motor control. Nevertheless, its exact functional significance has yet to be solved. Transcranial alternating current stimulation (tACS) allows the frequency-specific modulation of ongoing oscillatory activity. The goal of the present study was to investigate the effect of 10 and 20 Hz tACS over left primary motor cortex (M1) on motor functions and cortical excitability in healthy subjects. To this end, tACS was applied for 10 min. Sham stimulation served as control condition. Movement speed and accuracy of the right hand were assessed in 15 right-handed subjects before and after (0, 30 and 60 min) tACS of M1. Cortical silent period (CSP) and motor evoked potentials (MEPs) were determined as measures of M1 excitability. While 10 Hz tACS particularly increased movement variability, especially in tasks requiring internal pacing, 20 Hz tACS resulted in movement slowing. Behavioural effects occurred in distinct time windows. While 10 Hz effects developed over 30 min after stimulation, 20 Hz tACS effects were found immediately after stimulation. Following 10 Hz tACS these effects were significantly correlated with CSP duration, indicating interference with inhibitory pathways. The present findings suggest differential effects of stimulation frequency on motor behaviour and M1 excitability.