ABSTRACT
From the overall framework of battery development, the battery structures have not received enough attention compared to the chemical components in batteries. The mechanical-electrochemical coupling behavior is a starting point for investigation on battery structures and the subsequent battery design. This perspective systematically reviews the efforts on the mechanics-based design for lithium-ion batteries (LIBs). Two typical types of mechanics-based LIB designs, namely the design at the preparation stage and that at the cycling stage, have been discussed, respectively. The former systemizes the structure design of multiscale battery components from the particle level to the cell level. The latter focuses on the external mechanics-related control, including external pressures and charge-discharge protocols, of in-service LIBs. Moreover, the general problems currently being faced in the mechanics-based LIB design are summarized, followed by the outlook of possible solutions.
ABSTRACT
The Fe(III)-S(IV) system used for advanced oxidation processes (AOPs) at acidic pH has just been proposed and demonstrated valid for very few contaminants in the last several years. In this work, we investigated the effect of ultraviolet A (UVA) radiation on the degradation efficiency of the Fe(III)/S(IV) system at near-neutral pH. Paracetamol (PARA) was selected as a model contaminant. The influencing factors, such as initial pH and Fe(III)/S(IV) molar ratio on chemical kinetics, and the mechanism of PARA degradation are investigated, with an emphasis on the determination of dominant oxidant species. Our results show that irradiation enhances the PARA degradation by accelerating the decrease of pH to acidic levels, and the optimal pH for the degradation of PARA in the Fe(III)/S(IV)/O2 system was around 4.0. At near-neutral pH, more than 60% of PARA was decomposed within 40 min under irradiation, whereas no significant degradation of PARA was observed using Fe(III)/S(IV) at pH 7.0 without irradiation. Mechanism investigation revealed that sulfate radical (SO4â¢â) is the main oxidant species generated and responsible for the PARA degradation under these conditions. This finding may have promising implications in developing a new degradation process for dealing with wastewater at near-neutral pH by the Fe(III)/S(IV)/O2 system under UVA irradiation.
Subject(s)
Acetaminophen , Water Pollutants, Chemical , Iron , Oxidants , Oxidation-Reduction , Sulfites , Water Pollutants, Chemical/analysisABSTRACT
A deep eutectic solvent functionalized graphene oxide composite adsorbent (DFG) was synthesized through reversible-addition fragmentation chain-transfer polymerization. The synthesized DFG had multiple adsorption interactions after covalent modification with a deep eutectic solvent (allyltriethylammonium bromide/ethylene glycol). Adsorption isotherms and kinetics studies of DFG indicate that the adsorption of hippuric acid (HA) and methylhippuric acid (MHA) was monolayer chemical adsorption. The comparison of DFG with commercial adsorbents demonstrates that the adsorption ability of DFG was superior. This was due to the multiple adsorption interactions of DFG for the three analytes (mainly π-interaction, hydrogen bonding, electrostatic adsorption, and hydrophobic interaction). The DFG adsorbent was applied to miniaturized pipette-tip solid-phase extraction (MPT-SPE), followed by high-performance liquid chromatography (HPLC) to determine biomarkers in urine for toluene and xylene exposure. The DFG-MPT-SPE-HPLC method required only 2.00 mg of DFG as adsorbent, 0.50 mL of washing solvent, and 0.40 mL of elution solvent to achieve a wide linear range (0.200-200 µg mL-1), high recoveries (90.9-99.1%), and high precision (RSD ≤ 6.3%). The proposed method was applied to determine HA and MHA in urine samples from occupational workers. Graphical abstract Deep eutectic solvent functionalized graphene oxide composite adsorbent for miniaturized pipette-tip solid-phase extraction of toluene and xylene exposure biomarkers in urine prior to their determination with HPLC-UV.
Subject(s)
Graphite/chemistry , Ionic Liquids/chemistry , Toluene/urine , Xylenes/urine , Adsorption , Biomarkers/chemistry , Biomarkers/urine , Chromatography, High Pressure Liquid , Graphite/chemical synthesis , Humans , Ionic Liquids/chemical synthesis , Quaternary Ammonium Compounds/chemical synthesis , Quaternary Ammonium Compounds/chemistry , Solid Phase Extraction/instrumentation , Solid Phase Extraction/methods , Solvents/chemical synthesis , Solvents/chemistry , Toluene/chemistry , Toluene/isolation & purification , Xylenes/chemistry , Xylenes/isolation & purificationABSTRACT
A highly efficient palladium-catalyzed Sonogashira coupling of benzylic ammonium salts with terminal alkynes is developed. This strategy provides a facile access to a series of internal alkyne derivatives in moderate to excellent yields via C-N bond cleavage and C(sp3)-C(sp) bond formation. The broad substrate scope and high functional group tolerance make this reaction attractive for organic synthesis.
ABSTRACT
Classical Representative Famous Prescription is the valuable cultural heritage of Chinese medicine. In November 2018,the State Council issued the " Intensive Implementation of the National Intellectual Property Strategy in 2018 to Accelerate the Construction of IP Strong Country",explicitly proposing to strengthen the intellectual property protection of Classical Representative Famous Prescription.How about the current situation of intellectual property protection of lassical Representative Famous Prescription in China? We selected Liuwei Dihuang Pills,Shengmai Powder and Guizhi Fuling Pills( three representative drugs on market) from Chinese Pharmacopoeia2015 Volume I issued by Chinese Pharmacopoeia Commission to analyze their patent layout,reflecting its status quo of patent protection as follows: first,in recent years,the number of related patent applications for Classical Representative Famous Prescriptions has declined,which was positively correlated with the drug registration and approval policies in recent years,but the policy dividend has not been reflected in the patent application,which may be related to the long period of pharmaceutical R&D; secondly,the patent applicant in the field of Chinese medicine is mainly based on individuals,but the applicant of Classical Representative Famous Prescription is mainly of enterprises,and in addition,the company applicants have the highest authorization rate; thirdly,the main technologies are to improve preparation method and the dosage form in the research and development of Classical Representative Famous Prescription,but these two types of authorized patents have much difficulty in further application on the market. Therefore,the innovative entities shall look for a new breakthrough in secondary development and utilization of Classical Representative Famous Prescriptions.
Subject(s)
Medicine, Chinese Traditional , Patents as Topic , China , Drug Combinations , Drugs, Chinese HerbalABSTRACT
A recent paper "A New Elliptical Model for Device-Free Localization" (Sensors 2016, 16, 577) presents a new geometry-based elliptical model for Device-free localization (DFL). In this comment, we point out some problems of the original paper and exploit the same data used in the original paper to demonstrate the existence of these problems. Then, we give a modified formula to correct their model. Meanwhile, a real experiment is performed to verify our conclusion.
ABSTRACT
A new ionic liquid-magnetic graphene (IL-MG) composite was used as the adsorbent in magnetic dispersive solid-phase extraction to rapidly extract and isolate triazine herbicides from surface water. IL-MG was synthesized by a simple and time-saving one-pot strategy where the synthesis of magnetic Fe3O4, the modification with an IL, and the reduction of graphene oxide to graphene were conducted at the same time. An IL was applied to enrich the interaction mechanism between IL-MG and analytes (π-π, hydrophobic interaction, and electrostatic interaction). Moreover, the IL and Fe3O4 nanoparticles acted as spacers, inserting between the layers of graphene to prevent the aggregation of graphene, which improved the adsorption ability because of the large specific surface area of IL-MG. The resultant IL-MG had hierarchical flake structures and showed a high adsorption capacity (8266.0-12 324.1 µg g-1) toward triazine herbicides. Under suitable conditions, the linearity for triazine herbicides was achieved in the range of 0.55-500 ng mL-1 with a detection limit of 0.09-0.15 ng mL-1 and a quantitation limit of 0.31-0.51 ng mL-1, and the enrichment factor was 83-fold, which indicated that the proposed method could be successfully applied for the determination of triazine herbicides in surface water.
ABSTRACT
BACKGROUND: Congenital contractural arachnodactyly (CCA) is an autosomal dominant rare genetic disease, estimated to be less than 1 in 10,000 worldwide. People with this condition often have permanently bent joints (contractures), like bent fingers and toes (camptodactyly). CASE PRESENTATION: In this study, we investigated the genetic aetiology of CCA in a four-generation Chinese family. The blood samples were collected from 22 living members of the family in the Yangquan County, Shanxi Province, China. Of those, eight individuals across 3 generations have CCA. Whole exome sequencing (WES) identified a missense mutation involving a T-to-G transition at position 3229 (c.3229 T > G) in exon 25 of the FBN2 gene, resulting in a Cys 1077 to Gly change (p.C1077G). This previously unreported mutation was found in all 8 affected individuals, but absent in 14 unaffected family members. SIFT/PolyPhen prediction and protein conservation analysis suggest that this novel mutation is pathogenic. Our study extended causative mutation spectrum of FBN2 gene in CCA patients. CONCLUSIONS: This study has identified a novel missense mutation in FBN2 gene (p.C1077G) resulting in CCA in a family of China.
Subject(s)
Arachnodactyly/genetics , Asian People/genetics , Contracture/genetics , Fibrillin-2/genetics , Alleles , Amino Acid Sequence , Animals , Arachnodactyly/diagnosis , Base Sequence , China , Contracture/diagnosis , DNA/chemistry , DNA/isolation & purification , DNA/metabolism , DNA Mutational Analysis , Genotype , Humans , Male , Molecular Sequence Data , Mutation, Missense , Pedigree , Sequence AlignmentABSTRACT
A pipette-tip solid-phase extraction (PT-SPE) method using a sol-gel hybrid adsorbent has been developed. The method could be used for rapid screening of vegetable matrices for cyanazine and atrazine; assay of cucumbers is reported as an example. The sol-gel hybrid adsorbent was synthesized from tetraethyl orthosilicate (TEOS) as the precursor and γ-(methacryloyloxy)propyltrimethoxysilane (KH570) as both surface modifying agent and monomer for the polymerization. Under the optimized conditions, good calibration linearity was obtained in the range 0.022-1.65 µg g(-1) with correlation coefficients (r) ≥0.9996. Recovery at three spike levels ranged from 87.6 to 93.8 % with relative standard deviations ≤7.8 %. This extraction strategy has several advantages, for example ease of assembly, low cost, and high extraction efficiency, and is a potential pretreatment strategy for rapid screening of cyanazine and atrazine in vegetables.
Subject(s)
Atrazine/analysis , Cucumis sativus/chemistry , Food Analysis/methods , Methacrylates/chemistry , Silanes/chemistry , Solid Phase Extraction/methods , Triazines/analysis , Adsorption , Microscopy, Electron, Scanning , Surface Properties , Time FactorsABSTRACT
The identification of dietary exposure biomarkers is crucial for advancing our understanding of the health benefits of specific foods. Broccoli, a vegetable with well-known anticancer properties, contains active ingredients, such as isothiocyanates with indole side chains. Hence, indole metabolites related to broccoli consumption have the potential to serve as biomarkers of dietary exposure. In this work, we developed a new analytical method for indole metabolites in urine using a poly(deep eutectic solvents)-molecularly imprinted polymer/vinyl-functionalized graphene oxide (PDESs-MIP/VGO) in miniaturized centrifugal pipet-tip solid-phase extraction (CPT-SPE) coupled with liquid chromatography. This method integrates the strengths of PDESs-MIP/VGO, including rich adsorption interactions, high adsorption capacity, and excellent selectivity, with the simplicity and cost-effectiveness of CPT-SPE. The proposed method demonstrated low limits of quantification (1.2-2.5 ng mL-1), high accuracy (91.7-104.8%), and good precision (relative standard deviation ≤4.4%). By applying this method to analyze indole metabolites in urine, our results suggested that indole-3-carbinol and indole-3-acetonitrile have the potential to emerge as reliable dietary exposure biomarkers for broccoli intake. Furthermore, highly selective analytical methods based on molecular imprinting technology are advantageous for precise screening and analysis of dietary exposure biomarkers associated with food consumption.
Subject(s)
Biomarkers , Brassica , Indoles , Solid Phase Extraction , Humans , Indoles/urine , Indoles/metabolism , Biomarkers/urine , Brassica/chemistry , Brassica/metabolism , Solid Phase Extraction/methods , Dietary Exposure , Chromatography, High Pressure Liquid/methods , Molecularly Imprinted Polymers/chemistry , Molecularly Imprinted Polymers/metabolism , GraphiteABSTRACT
The escalating use of pesticides on fruits and vegetables has raised concerns about potential health risks. Therefore, we developed a superhydrophilic resin/graphene oxide (SR/GO) with rich adsorption interactions using an eco-friendly synthetic approach. SR/GO demonstrated excellent hydrophilicity, ensuring optimal contact with aqueous sample matrices. The multiple adsorption interactions, including π-π conjugation, hydrogen bonding, and electrostatic adsorption, facilitated multi-pesticide residue co-extraction. The synthesized SR/GO was applied to a miniaturized centrifugation-accelerated pipette-tip extraction method, coupled with high-performance liquid chromatography. The optimized method exhibited low consumption (15.0 mg adsorbent), and high efficiency, with low detection limits (1.4-2.9 ng g-1) and high recoveries (75.3-113.0%). Water-compatible SR/GO, along with a miniaturized extraction process, showcases a potent analytical approach for pesticide residue analysis in fruits and vegetables. The significance of this method lies in its ability to ensure agricultural and food safety by using a low-cost and efficient multi-pesticide residue analytical strategy.
Subject(s)
Fruit , Vegetables , Hydrophobic and Hydrophilic Interactions , Graphite/chemistry , Pesticide Residues/chemistry , Fruit/chemistry , Vegetables/chemistry , Pyrus/chemistry , Citrullus/chemistry , Solanum lycopersicum/chemistry , Malus/chemistry , Cucurbita/chemistry , Chromatography, High Pressure LiquidABSTRACT
This study presents novel methodologies and materials for selectively and sensitively determining gibberellin traces in licorice to address food safety concerns. A novel hydrophilic imprinted resin-graphene oxide composite (HMIR-GO) was developed with fast mass transfer, high adsorption capacity, and exceptional aqueous recognition performance for gibberellin. Leveraging the advantages of molecular imprinting, hydrophilic resin synthesis, and rapid mass transfer characteristics of GO, HMIR-GO was employed as an adsorbent, showing resistance to matrix interference. Coupled with HPLC, a rapid and selective method for determining gibberellin was established. Under optimal conditions, the method exhibited a wide linear range (0.02-5.00 µg g-1, r = 0.9999), low detection limits (3.3 ng g-1), and satisfactory recoveries (92.0-98.4%), enabling the accurate and rapid detection of gibberellin in licorice. This study introduces a pioneering strategy for the selective extraction and determination of trace gibberellin levels, offering insights for similar applications in functional foods.
Subject(s)
Gibberellins , Glycyrrhiza , Graphite , Hydrophobic and Hydrophilic Interactions , Molecular Imprinting , Graphite/chemistry , Glycyrrhiza/chemistry , Gibberellins/chemistry , Gibberellins/analysis , Gibberellins/isolation & purification , Adsorption , Solid Phase Extraction/methods , Solid Phase Extraction/instrumentation , Chromatography, High Pressure Liquid , Limit of DetectionABSTRACT
In this study, the polysaccharide (RHCP) extracted from Houttuynia cordata rhizome was acetylated through the acetic anhydride method. The physicochemical properties of RHCP and its acetylated derivatives (Ac-RHCP) were determined by infrared spectra, scanning electron microscopy, and Congo red test. Meanwhile, the α-glucosidase inhibition mechanism of RHCP and Ac-RHCP was analyzed by inhibition kinetics, and circular dichroism and fluorescence spectroscopy. Ac-RHCP resulted in a more porous surface structure and 1.83-fold higher solubility compared with RHCP. At a concentration of 6 mg/mL, the α-glucosidase inhibition rate of Ac-RHCP was 75.40%, while that of RHCP was 44.68%. RHCP and Ac-RHCP inhibited α-glucosidase in a mixed-type manner, reduced the endogenous fluorescence of α-glucosidase, affected the microenvironment of amino acid residues, and changed the conformation of α-glucosidase. The study indicates that Ac-RHCP exhibits a certain level of α-glucosidase inhibition, demonstrating its potential as a functional food for glycemic control.
Subject(s)
Glycoside Hydrolase Inhibitors , Houttuynia , Polysaccharides , Rhizome , alpha-Glucosidases , Glycoside Hydrolase Inhibitors/pharmacology , Rhizome/chemistry , alpha-Glucosidases/metabolism , Houttuynia/chemistry , Acetylation , Polysaccharides/chemistry , Polysaccharides/pharmacology , Kinetics , Circular Dichroism , Solubility , Spectrometry, FluorescenceABSTRACT
Overweight and obesity are the causes of many diseases and have become global "epidemics". Research on natural active components with anti-adipogenesis effects in plants has aroused the interest of researchers. One of the most critical problems is establishing sample preparation and analytical techniques for quickly and selectively extracting and determining the active anti-adipogenesis components in complex plant matrices for developing new anti-adipogenic drugs. In this study, a new poly(deep eutectic solvents) surface imprinted graphene oxide composite (PDESs-MIP/GO) with high selectivity for phenolic acids was prepared using deep eutectic solvents as monomers and crosslinkers. A miniaturized centrifugation-accelerated pipette-tip matrix solid-phase dispersion method (CPT-MSPD) with PDESs-MIP/GO as adsorbent, coupled with high-performance liquid chromatography, was further developed for the rapid determination of anti-adipogenesis markers in Solidago decurrens Lour. (SDL). The established method was successfully used to determination anti-adipogenesis markers in SDL from different regions, with the advantages of accuracy (recoveries: 94.4 - 115.9 %, RSDs ≤ 9.8 %), speed (CPT-MSPD time: 11 min), selectivity (imprinting factor: â¼2.0), and economy (2 mg of adsorbent and 1 mL of solvents), which is in line with the current advanced principle of "3S+2A" in analytical chemistry.
Subject(s)
Deep Eutectic Solvents , Graphite , Solidago , Solid Phase Extraction/methods , Solvents/chemistry , Chromatography, High Pressure LiquidABSTRACT
The performance of zinc-air battery is constrained by the sluggish rate of oxygen electrode reaction, particularly under high current discharge conditions where the kinetic process of the oxygen reduction reaction (ORR) decelerates significantly. To address this challenge, we present a novel phase transition strategy that facilitates the creation of a heteroatom-doped heterointerface (CoN/CoS2). The meticulously engineered CoN/CoS2/NC electrocatalyst displays a superior ORR half-wave potential of 0.87â V and an OER overpotential of 320â mV at 10â mA cm-2. Experimental and computational analysis confirm that the CoN/CoS2 heterostructure optimizes local charge distribution, accelerates electron transfer, and tunes active sites for enhanced catalysis. Notably, this heterojunction improves stability by resisting corrosion and degradation under harsh alkaline conditions, thus demonstrating superior performance and longevity in a custom-made liquid zinc-air battery. This research provides valuable practical and theoretical foundations for designing efficient heterointerfaces in electrocatalysis applications.
ABSTRACT
A brand-new enhanced starvation is put forward to trigger sensitized chemotherapy: blocking tumor-relation blood vessel formation and accelerating nutrient degradation and efflux. Following this concept, two cisplatin-like gemfibrozil-derived Pt(IV) prodrugs, GP and GPG, are synthesized. GP and GPG had nanomolar IC50 against A2780 cells and higher selectivity against normal cells than cisplatin. Bioactivity results confirmed that GP and GPG highly accumulated in cells and induced DNA damage, G2-phase arrest, and p53 expression. Besides, they could increase ROS and MDA levels and reduce mitochondrial membrane potential and Bcl-2 expression to promote cell apoptosis. In vivo, GP showed superior antitumor activity in A2780 tumor-bearing mice with no observable tissue damage. Mechanistic studies suggested that highly selective chemotherapy could be due to the new enhanced starvation effect: blocking vasculature formation via inhibiting the CYP2C8/EETs pathway and VEGFR2, NF-κB, and COX-2 expression and cholesterol efflux and degradation acceleration via increasing ABCA1 and PPARα.
Subject(s)
Antineoplastic Agents , Gemfibrozil , Animals , Humans , Mice , Antineoplastic Agents/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/chemical synthesis , Apoptosis/drug effects , Cell Line, Tumor , Gemfibrozil/pharmacology , Mice, Inbred BALB C , Organoplatinum Compounds/pharmacology , Organoplatinum Compounds/chemistry , Prodrugs/pharmacology , Prodrugs/chemistry , Prodrugs/chemical synthesisABSTRACT
As a host for exchange bias (EB), van der Waals (vdW) magnetic materials have exhibited intriguing and distinct functionalities from conventional magnetic materials. The EB in most vdW systems is far below room temperature, which poses a challenge for practical applications. Here, by using Kerr microscopy, we demonstrate a record-high blocking temperature that approaches room temperature and a huge positive EB field that nears 2 kOe at 100 K in naturally oxidized two-dimensional (2D) vdW ferromagnetic Fe3GaTe2 nanoflakes. Moreover, we realized a reversible manipulation of both the presence/absence and positive/negative signs of EB via a training magnetic field without multiple field cooling processes. Thus, our study clearly reveals the robust, sizable, and sign-tunable EB in vdW magnetic materials up to near room temperature, thereby establishing Fe3GaTe2 as an emerging room-temperature-operating vdW material and paving the way for designing practical 2D spintronic devices.
ABSTRACT
BACKGROUND: The aims of this study were to evaluate the antioxidant activity and to identify the antioxidant components of a traditional Chinese medicine formula consisting of a combination of Shanzha (the fruit of Crataegus pinnatifida Bge. var. major N.E.Br., SZ) and Danshen (the root of Salvia miltiorrhiza Bge., DS). This medicine is extensively used to treat cardiovascular disease. METHODS: Twelve samples extracted and fractionated from SZ, DS and the formula (SZ+DS) were analyzed. The concentrations of eight phenolic compounds were determined by high performance liquid chromatography. Oxygen radical absorbance capacity (ORAC) assay and 1,1-diphenyl-2-picrylhydrazyl assay were conducted to explore the antioxidant activities of the samples and of the 15 phenolic compounds detected. Correlation analysis of the antioxidant activity of herb samples and their phenolic components was performed. RESULTS: The main phenolic component in all SZ+DS samples was salvianolic acid B, which exhibited strong antioxidant activity (ORAC value: 16.73 ± 2.53, IC50 value: 8.80 ± 0.06 µM) compared with the other phenolic compounds. For all samples, there was a positive relationship between their total phenolic components and their antioxidant activities. CONCLUSIONS: Phenolic compounds were the bioactive components of the herb samples, and salvianolic acid B was identified as the main bioactive compound in the SZ+DS formula.
Subject(s)
Antioxidants/analysis , Crataegus/chemistry , Drugs, Chinese Herbal/analysis , Salvia miltiorrhiza/chemistry , Chemistry, Pharmaceutical , Chromatography, High Pressure Liquid , Phenols/analysisABSTRACT
Osimertinib (OSIM) is widely used as a mainstream drug for the treatment of non-small cell lung cancer (NSCLC). However, the lack of a rapid extraction and detection method for OSIM and its metabolite, AZ-5104, has limited clinical drug metabolism and drug resistance research because the drug is unstable. In this study, a new ionic liquid hybrid hierarchical porous material (IL-HHPM) was synthesized with hierarchical porous structures, including micropores (1.6-2.0 nm), mesopores (2.0-50.0 nm), macropores (50.0-148.7 nm), and multiple functional groups via a one-step hydrothermal method using silanized ionic liquids (IL) as functionalized hybrid monomer. The IL-HHPM has the advantages of a high specific surface area (437.4 ± 4.6 m2 g-1), sizable pore volume (0.74 cm3 g-1), and fast mass transfer, additionally, the IL-HHPM adsorbed OSIM and AZ-5104 via π-π interactions and hydrogen bonding. OSIM and AZ-5104 were rapidly extracted and measured in human urine using rapid and miniaturized centrifugal spin-column extraction (MCSCE), which was based on the IL-HHPM. The optimized factors for the extraction recoveries of OSIM and AZ-5104 were adsorbent dosage (8.0 mg), sample volume (0.5 mL), and operation time (9.0 min), and markedly reduced the adsorbent dosage and operation time. The IL-HHPM-MCSCE-HPLC method displayed good linearity (0.02-5.00 µg mL-1, r ≥ 0.9997), satisfying accuracy (spiked recoveries of 87.7%-100.0%), and good precision (RSDs ≤ 7.0%). The developed method is rapid, sensitive, and reproducible for the simultaneous determination of trace level of OSIM and AZ-5104 in human urine.
Subject(s)
Carcinoma, Non-Small-Cell Lung , Ionic Liquids , Lung Neoplasms , Humans , Ionic Liquids/chemistry , Porosity , Chromatography, High Pressure Liquid/methods , Solid Phase Extraction/methodsABSTRACT
Based on the adhesion and surface properties of Lactobacillus acidophilus NCFM, five common polyphenols in fruits and vegetables, including resveratrol, epicatechin, quercetin, hesperidin, and caffeic acid, were screened, and the reasons for resveratrol promoting adhesion were systematically explained. The results showed that resveratrol could significantly enhance NCFM adhesion to mucin (1.73 fold), followed by epicatechin (1.47 fold), caffeic acid (1.30 fold), and hesperidin (0.99 fold), while quercetin had a certain degree of inhibition (0.84 fold). The effects of these polyphenols on surface hydrophobicity and auto-aggregation of NCFM were consistent with adhesion results. Then, how resveratrol promotes NCFM adhesion was further explored. The results of the proteomic analysis showed that resveratrol changed the surface layer proteins of NCFM, involving 4 up-regulated proteins and 12 down-regulated proteins. In addition, resveratrol promoted the expression of mucin genes and the glycosylation of mucins on the HT-29 cell surface. Our results indicate that resveratrol changes the surface layer proteins of NCFM to modify surface properties and adhere to mucins. Meanwhile, resveratrol promotes expression and glycosylation of mucins in HT-29 cells. Our findings provide theoretical support for an in-depth explanation of the interaction among resveratrol, NCFM, and the HT-29 cells.