Prosocial motives underlie scientific censorship by scientists: A perspective and research agenda.

Science is among humanity's greatest achievements, yet scientific censorship is rarely studied empirically. We explore the social, psychological, and institutional causes and consequences of scientific censorship (defined as actions aimed at obstructing particular scientific ideas from reaching an audience for reasons other than low scientific quality). Popular narratives suggest that scientific censorship is driven by authoritarian officials with dark motives, such as dogmatism and intolerance. Our analysis suggests that scientific censorship is often driven by scientists, who are primarily motivated by self-protection, benevolence toward peer scholars, and prosocial concerns for the well-being of human social groups. This perspective helps explain both recent findings on scientific censorship and recent changes to scientific institutions, such as the use of harm-based criteria to evaluate research. We discuss unknowns surrounding the consequences of censorship and provide recommendations for improving transparency and accountability in scientific decision-making to enable the exploration of these unknowns. The benefits of censorship may sometimes outweigh costs. However, until costs and benefits are examined empirically, scholars on opposing sides of ongoing debates are left to quarrel based on competing values, assumptions, and intuitions.

Harm Hypervigilance in Public Reactions to Scientific Evidence.

Two preregistered studies from two different platforms with representative U.S. adult samples (N = 1,865) tested the harm-hypervigilance hypothesis in risk assessments of controversial behavioral science. As expected, across six sets of scientific findings, people consistently overestimated others' harmful reactions (medium to large average effect sizes) and underestimated helpful ones, even when incentivized for accuracy. Additional analyses found that (a) harm overestimations were associated with support for censoring science, (b) people who were more offended by scientific findings reported greater difficulty understanding them, and (c) evidence was moderately consistent for an association between more conservative ideology and harm overestimations. These findings are particularly relevant because journals have begun evaluating potential downstream harms of scientific findings. We discuss implications of our work and invite scholars to develop rigorous tests of (a) the social pressures that lead science astray and (b) the actual costs and benefits of publishing or not publishing potentially controversial conclusions.

Strengthening the interpretability of clinical trial results by assessing the effect of informative censoring on the primary estimand in PRECISION.

BACKGROUND: The ICH E9(R1) addendum states that the strategy to account for intercurrent events should be included when defining an estimand, the treatment effect to be estimated based on the study objective. The estimator used to assess the treatment effect needs to be aligned with the estimand that accounted for intercurrent events. Regardless of the strategy, missing data resulting from patient premature withdrawal could undermine the robustness of the study results. Informative censoring due to dropouts in an events-based study is one such example. Sensitivity analyses using imputation methods are useful to examine the uncertainty due to informative censoring and address the robustness and strength of the study results. METHODS: We assessed the effect of premature patient withdrawal in the PRECISION study, a randomized non-inferiority clinical trial of patients with chronic arthritic pain that compared the cardiovascular safety of three nonsteroidal anti-inflammatory drugs-based treatment policies or paradigms. The protocol-defined use of concomitant or rescue medications was permitted since changes in pain medications due to insufficient analgesia were expected in patients in this long-term study. Anticipating that premature study discontinuations could potentially lead to informative censoring, a supplementary analysis was pre-specified in which censored outcomes due to the premature study discontinuation were imputed based on adverse events that were clinically associated with the primary endpoint (cardiovascular outcome based on the Antiplatelet Trialists Collaboration composite endpoint). Furthermore, tipping point analyses were conducted to test the robustness of the primary analysis results by assuming data censored not at random. The level of increase at which the primary study conclusion would change was estimated. RESULTS: For the analysis of time to first primary endpoint event through 30 months, 4065 out of the 24,081 enrolled patients were lost to follow-up, withdrew consent, or were no longer willing to participate in the study. These withdrawals occurred gradually and resulted in a cumulative total of 5893 censored patient-years of observation (10.2%). The rate of discontinuation and the baseline characteristics of the discontinued patients were similar across the three treatment groups. The non-inferiority conclusion from the primary analysis was confirmed in the supplementary analysis incorporating relevant adverse events. Furthermore, tipping point analyses demonstrated that in order to lose non-inferiority in the primary analysis, the risk of primary endpoint events during the censored observation time would have to increase by more than 2.7-fold in the celecoxib group while remaining constant in the other nonsteroidal anti-inflammatory drugs groups, demonstrating that the scenarios where the study results are invalid appear not plausible. CONCLUSIONS: Supplementary and sensitivity analyses presented to address informative censoring in PRECISION helped to further interpret and strengthen the study results.

[Psychiatric textbooks from National Socialism and the censorial practice in the Soviet Occupation Zone and early GDR]. / Psychiatrische Fachbücher aus dem Nationalsozialismus und die zensorische Praxis in der SBZ und frühen DDR.

The Allied Forces policy of denazification and demilitarization during the early post-war period has had a lasting impact on medical disciplinary cultures in all occupation zones of Germany. By means of various control procedures, the conceptuality and linguistic design, the style and normative horizon of medical literature were reconstituted. This article examines this change using the example of psychiatry and neurology in the Soviet Occupation Zone. It deals with the neurological psychiatric textbook as a central medium of disciplinary communication and reconstructs how the knowledge in this field was processed and prepared in complex negotiation processes between authors, publishers and censors. The focus is on institutionalized filters of limited production of discourses and thus the archival holdings of censorship authorities, which have not yet been evaluated. The evaluation results are presented here with a focus on psychiatry and neurology and illustrated with selected case studies.

National Socialist Medical Literature and the Censorship Practices in the Soviet Occupation Zone and Early East German State.

This study examines how medical discourse and culture were affected by the denazification policies of the Soviet occupation authorities in East Germany. Examining medical textbooks in particular, it reveals how the production and dissemination of medical knowledge was subject to a complex process of negotiation among authors, publishers, and censorship officials. Drawing on primary-source material produced by censorship authorities that has not been rigorously examined to date, it reveals how knowledge production processes were structured by broader ideological and political imperatives. It thus sheds new light on a unique chapter in the history of censorship.

The bounded heavens: defining the limits of astrological practice in the Iberian indices.

This paper explores the rules for the expurgation of texts of astrology in the Iberian Indices of forbidden books. It addresses the prohibitions put forward in Rule IX of the Index of Trent and the bull Coeli et terrae of Sixtus V, and studies its impact on the rules and their interpretation in the Spanish and Portuguese Indices, in particular, those published in the first decades of the seventeenth century: the Spanish Index librorum prohibitorum et expurgatorum of 1612 and the Portuguese Index auctorum damnatae memoriae of 1624. It shows how these indices offer a more meticulous examination of the prohibitions providing not only more detail regarding the different practices of astrology, but also explicitly accept the doctrine of inclinations of Thomas Aquinas as a central rule to deal with astrological judgments on human behaviour. It also highlights some specific details of the practice of censorship of astrological books by examining case studies of censored Portuguese and Spanish astrological publications. These provide new dimensions and highlight significant differences between the theoretical rules, practical guidelines, and actual restriction of astrological content.

Preludes to the Inquisition: self-censorship in medieval astrological discourse.

Astrologers have exercised self-censorship throughout the centuries in order to fend off criticism. This was largely for religious reasons, but social, political, and ethical motivations also have to be taken into account. This paper explores the main reasons that led astrologers to increase censorship in their writings in the decades that preceded the Church's regulations and offers some examples of this self-imposed restraint in astrological judgements.

Newtonianism and information control in Rome at the wake of the eighteenth century.

This paper offers an opportunity to ponder the way the Catholic Church and its methods of information control reshaped, and paradoxically even enabled, the dissemination and practice of science in early modern Italy. Focusing on the activities of Newtonian scholars operating in Rome in the First half of the eighteenth century - especially the Celestine monk Celestino Galiani (1681-1753) and prelate Francesco Bianchini (1662-1729) - I will argue that major contributions to the spread of Newtonianism in Italy came from individuals operating within the Church, acting more-or-less independently from the Church's oversight. These scholars realized they were witnessing an inexorable transition and that the medieval scholastic cosmology and physics could not survive. In order to rescue the Church - and to avoid further embarrassment, especially after the Galileo Affair - renewal was needed. Counterintuitively, the dissemination of Italian Newtonianism was largely a Catholic effort.

Reconstructing Thomist astrology: Robert Bellarmine and the papal bull Coeli et terrae.

Historians have portrayed the papal bull Coeli et terrae (1586) as a significant turning point in the history of the Catholic Church's censorship of astrology. They argue that this bull was intended to prohibit the idea that the stars could naturally incline humans towards future actions, but also had the effect of preventing the discussion of other forms of natural astrology including those useful to medicine, agriculture, and navigation. The bull, therefore, threatened to overturn principles established by Thomas Aquinas, which not only justified long-standing astrological practices, but also informed the Roman Inquisition's attitude towards this art. The promulgation of the bull has been attributed to the 'rigour' of the incumbent pope, Sixtus V. In this article I revise our understanding of this bull in two ways. First, I reconsider the Inquisition's attitude towards astrology in the mid-sixteenth century, arguing that its members promoted a limited form of Thomist astrology that did not permit the doctrine of inclination. Second, using Robert Bellarmine's unpublished lectures discussing Aquinas's views of astrology, I suggest that this attitude was common during the sixteenth century, and may have been caused by the crisis of Renaissance astrology precipitated by the work of Giovanni Pico.

Putting the Indices into practice: censoring science in early modern Portugal.

During the sixteenth and seventeenth centuries, the Inquisition was the institution most invested in the censorship of printed books in the Portuguese empire. Besides publishing the Indices of Forbidden Books, the Holy Office was also responsible for overseeing their implementation and ensuring their efficacy in preventing the importation, reading, and circulation of banned books. Overall, the sixteenth-century Indices condemned 785 authors and 1081 titles, including 52 authors and 85 titles of medicine, natural history, natural philosophy, astronomy, chronology, cosmography, astrology, and divinatory arts. By looking at the largest collection of early modern scientific books in Portugal, I will argue that a closer inspection of marginalia and ownership, and the establishment of a typology of expurgations is essential for the comprehension of the actual practices and the mechanisms of censorship. By examining the material evidence of censorship, in order to reconstruct expurgation practices, this paper reveals the processes and effectiveness of ecclesiastical control in the Portuguese Inquisition and highlights the differences between what inquisitors wrote in the Indices and what others put into practice.

On the censorship of Tycho Brahe's books in Iberia.

It is known that throughout the seventeenth century the world system proposed by Tycho Brahe (1546-1601) assumed a preponderant position in the Iberian cosmological debate, according to many opinions the one showing the best agreement to empirical evidence. Moreover, the Tychonian model (or variants thereof) did not present the difficulties of apparent contradiction with scriptures, as the heliocentric system of Nicolaus Copernicus (1473-1543) did, since it kept the earth fixed at the centre of the world. However, Tycho, as a Lutheran author, was targeted by the Inquisition. Passages of various works of the Danish astronomer were included in the Spanish Indices of 1632, 1640 and 1707, although the formal condemnation of the Roman Inquisition never materialized. In the network of the Society of Jesus a seemingly informal censorship also circulated, apparently based on Tridentine determinations, published in 1651 in the influential work of Giambattista Riccioli (1598-1671) Almagestum novum. In this paper I will discuss the scope, effects and limitations of the censorship of Tycho's scientific books in Portugal and Spain, through the analysis of several annotated copies, preserved manly in Iberian libraries, with a special attention to books with a well-established provenance in past Jesuit colleges.