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1.
BMC Musculoskelet Disord ; 24(1): 412, 2023 May 24.
Article in English | MEDLINE | ID: mdl-37226140

ABSTRACT

PURPOSE: Negative buttress reduction should be avoided in the treatment of femoral neck fractures (FNFs) using conventional fixation. As the femoral neck system (FNS) has been recently developed and utilized widely to treat FNFs, the association of reduction quality with postoperative complications and clinical function has not been clarified. The purpose of this study was to evaluate the clinical effect of nonanatomical reduction in young patients with FNFs treated with FNS. METHODS: This multicenter, retrospective cohort study included 58 patients with FNFs treated with FNS between September 2019 and December 2021. According to the reduction quality immediately following surgery, patients were classified into positive, anatomical, and negative buttress reduction groups. Postoperative complications were assessed with 12 months of follow-up. The logistic regression model was used to identify risk factors for postoperative complications. The postoperative hip function was assessed using the Harris hip scores (HHS) system. RESULTS: At a follow-up of 12 months, a total of eight patients (8/58, 13.8%) had postoperative complications in three groups. Compared with the anatomical reduction group, negative buttress reduction was significantly associated with a higher complication rate (OR = 2.99, 95%CI 1.10-8.10, P = 0.03). No significant associations were found between positive buttress reduction and the incidence of postoperative complications (OR = 1.21, 95%CI 0.35-4.14, P = 0.76). The difference was not statistically significant in Harris hip scores. CONCLUSION: Negative buttress reduction should be avoided in young patients with FNFs treated with FNS.


Subject(s)
Femoral Neck Fractures , Fenofibrate , Fracture Fixation , Humans , Femoral Neck Fractures/surgery , Femur Neck/injuries , Femur Neck/surgery , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Postoperative Complications/prevention & control , Retrospective Studies , Fracture Fixation/adverse effects , Fracture Fixation/methods
2.
Biomacromolecules ; 21(2): 328-337, 2020 02 10.
Article in English | MEDLINE | ID: mdl-31637919

ABSTRACT

Hip fractures are among the most common types of fracture risks in old age osteoporotic patients that often end up with immobile disabilities. Weak bones due to loss of mineral content along with an increase in the porosity of the femur neck canal in osteoporosis reduce the mechanical properties of the bone and predispose the patients to fractures. In this study, we have used calcium sulfate/nanohydroxyapatite based nanocement (NC) as carrier of recombinant human bone morphogenetic protein-2 (BMP-2), zoledronate (ZA), and bone marrow mesenchymal stromal cells (MSCs) derived exosomes (EXO) to enhance bone formation and defect healing in a femur neck canal defect model in osteoporotic rats. A cylindrical defect in the femur neck canal with dimensions of 1 mm (diameter) × 8 mm (length) starting from the lateral cortex toward the apex of the femur head was developed. The defect was impacted using NC alone or functionalized as (a) NC + ZA (systemic), (b) NC + ZA (local), (c) NC + EXO + ZA, and (d) NC + BMP + ZA to evaluate bone formation by ex vivo micro-computed tomography (micro-CT) and histological analysis 16 weeks postsurgery. Moreover, the femurs (both defect and contralateral leg) were subjected to biomechanical analysis to assess the effect of treatments on compressive mechanical properties of the bones. The treatment groups (NC + ZA (L), NC + BMP + ZA, and NC + EXO + ZA) showed enhanced bone formation with complete healing of the defect. No differences in the mechanical properties of both the defect and contralateral across the leg were observed among the groups. However, a trend was observed where NC + BMP + ZA showed enhanced biomechanical strength in the defect leg. This suggests that NC could act as a potent carrier of bioactive molecules to reduce the risks of hip fractures in osteoporotic animals. This type of treatment can be given to patients who are at higher risk of osteoporosis mediated femur neck fracture as a preventive measure or for enhanced healing in already compromised situations. Moreover, this study provided a proof of concept regarding the use of exosomes in bone regeneration therapy, which might be used as a booster dose that will eventually reduce the dosage of BMP and hence circumvent the limitations associated with the use of BMP.


Subject(s)
Bone Morphogenetic Protein 2/administration & dosage , Femur Neck/injuries , Hydroxyapatites/chemistry , Osteogenesis/drug effects , Osteoporosis/physiopathology , Transforming Growth Factor beta/administration & dosage , Animals , Bone Density Conservation Agents/administration & dosage , Bone Density Conservation Agents/pharmacology , Bone Regeneration/drug effects , Bone Resorption/drug therapy , Calcium Sulfate/chemistry , Drug Carriers/administration & dosage , Drug Carriers/chemistry , Exosomes/metabolism , Female , Femur Neck/diagnostic imaging , Femur Neck/drug effects , Femur Neck/pathology , Hip Fractures/physiopathology , Hydroxyapatites/administration & dosage , Nanostructures/chemistry , Osteogenesis/physiology , Rats, Sprague-Dawley , Recombinant Proteins/administration & dosage , X-Ray Microtomography , Zoledronic Acid/administration & dosage , Zoledronic Acid/pharmacology
3.
Biol Pharm Bull ; 42(5): 778-785, 2019.
Article in English | MEDLINE | ID: mdl-31061320

ABSTRACT

Fragility fractures associated with age-related bone loss are of urgent concern worldwide because they reduce QOL and pose financial burdens for health care services. Currently, national data in Japan are limited. This study provides quantitative data for older patients throughout Japan who, although otherwise relatively healthy, sustained fragility fractures and were hospitalized for them. The National Database of Health Insurance Claims and Specific Health Checkups of Japan was accessed to target patients aged 65 years or older who sustained fractures between May 2013 and September 2014 and were not hospitalized for at least 13 months prior to fracture. We investigated whether the first fracture sustained was fragility related at any of four locations (proximal humerus, distal radius, vertebra, or femoral neck) and whether it necessitated hospitalization. Fragility fractures were identified in 490138 of 1188754 patients (41.2%, 345980 patients/year; 1 : 4 male-to-female ratio). Regardless of gender, vertebral fractures were most common across the age cohorts studied (43286 males and 162767 females/year), and femoral neck fractures increased markedly with increased patient age. Approximately 80% of patients with femoral neck fractures were hospitalized (62.3% of males, 71.1% of females) compared with up to 10.4% of patients with other fragility fractures. Data provided in this study can be used as a baseline for evaluating the health economy and establishing health policy in Japan.


Subject(s)
Fractures, Bone/epidemiology , Aged , Aged, 80 and over , Databases, Factual , Female , Femur Neck/injuries , Hospitalization , Humans , Humerus/injuries , Japan/epidemiology , Male , National Health Programs , Osteoporosis/epidemiology , Radius/injuries , Spinal Injuries/epidemiology
4.
BMC Musculoskelet Disord ; 20(1): 413, 2019 Sep 05.
Article in English | MEDLINE | ID: mdl-31488121

ABSTRACT

BACKGROUND: This study aimed to determine the influence of ageing on the incidence and site of femoral fractures in trauma patients, by taking the sex, body weight, and trauma mechanisms into account. METHODS: This retrospective study reviewed data from adult trauma patients aged ≥20 years who were admitted into a Level I trauma center, between January 1, 2009 and December 31, 2016. According to the femoral fracture locations, 3859 adult patients with 4011 fracture sites were grouped into five subgroups: proximal type A (n = 1359), proximal type B (n = 1487), proximal type C (n = 59), femoral shaft (n = 640), and distal femur (n = 466) groups. A multivariate logistic regression analysis was applied to identify independent effects of the univariate predictive variables on the occurrence of fracture at a specific site. A two-dimensional plot was presented visually with age and the propensity score accounts for the risk of a fracture at a specific femoral site. RESULTS: This analysis revealed that older age was an independent variable that could positively predict the occurrence of proximal type A (OR [95%CI]: 1.03 [1.03-1.04], p < 0.001) and B fractures (1.02 [1.01-1.02], p < 0.001), and negatively predict the occurrence of proximal type C (0.96 [0.94-0.98], p < 0.001), shaft (0.95 [0.95-0.96], p < 0.001), and distal fractures (0.98 [0.98-0.99], p < 0.001). DISCUSSION: Using the propensity scores which account for the risk of a fracture in a specific femoral site, this study revealed that the older patients were at a higher risk of developing proximal type A and type B fractures, while a lower risk of developing fractures in the shaft and distal femur. This incidence of fracture site can largely be explained by age-related factors, including a decrease in bone strength and falling being the most common mechanism of trauma in older patients. CONCLUSIONS: This study revealed a difference in the involvement of age in the incidence of femoral fracture sites in the trauma patients.


Subject(s)
Accidental Falls/statistics & numerical data , Aging/physiology , Femoral Fractures/epidemiology , Femur Head/injuries , Femur Neck/injuries , Adult , Age Factors , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Femoral Fractures/etiology , Femoral Fractures/physiopathology , Femur Head/physiopathology , Femur Neck/physiopathology , Humans , Incidence , Male , Middle Aged , Propensity Score , Retrospective Studies , Risk Factors , Trauma Centers/statistics & numerical data
5.
BMC Musculoskelet Disord ; 20(1): 358, 2019 Aug 07.
Article in English | MEDLINE | ID: mdl-31391031

ABSTRACT

BACKGROUND: Despite advances in operative techniques and preoperative care, proximal femur fractures (PFF) still represent a great public health problem. Displacement and fracture stability have been assumed as important determinants of treatment modality and outcome in such fractures. Purpose of this study was to determine whether the radiological severity of PFF fractures has increased over time. METHODS: In a cohort study, the plain radiographs of all patients with PFF aged over 50 years who were admitted to Umeå University Hospital in 1981/82, 2002 and 2012 were recruited to examine the types of fractures. RESULTS: The ratio of undisplaced to displaced femoral neck (FN) fractures was 30 to 70% in 1981/82, 28 to 72% in 2002 and 25 to 75% in 2012. The ratio of stable to unstable intertrochanteric (IT) fractures was 64 to 36% in 1981/82, 68 to 32% in 2002 and 75 to 25% in 2012. The ratio of simple to comminute subtrochanteric fractures was 35 to 65% in 1981/82, 16 to 84% in 2002 and 12 to 88% in 2012. In both FN and IT fractures we found no statistical difference among these 3 study periods, p = 0.67 and p = 0.40. In subtrochanteric fractures we saw a tendency towards more comminute subtrochanteric fractures (1981/82 to 2012), p = 0.09. CONCLUSIONS: We found no significant increment in the radiological severity of FN and IT over a 30 years' period. However, there was tendency towards an increase in comminute subtrochanteric fractures.


Subject(s)
Femur Neck/diagnostic imaging , Fracture Dislocation/diagnostic imaging , Hip Fractures/diagnostic imaging , Trauma Severity Indices , Female , Femur Neck/injuries , Fracture Dislocation/epidemiology , Hip Fractures/epidemiology , Humans , Incidence , Male , Middle Aged , Retrospective Studies , Sex Distribution , Sweden/epidemiology
6.
BMC Musculoskelet Disord ; 20(1): 449, 2019 Oct 15.
Article in English | MEDLINE | ID: mdl-31615567

ABSTRACT

BACKGROUND: Simultaneous bilateral femoral neck fracture is a very rare condition, even in osteoporotic elderly individuals. We report an atypical case of a young male adult who developed simultaneous bilateral femoral neck fractures without previous trauma or overuse. CASE PRESENTATION: A 33-year-old man presented with discomfort in the bilateral groin, which had started 2 weeks previously. Bilateral femoral neck fractures were observed on a radiograph, and in addition, a fracture line was seen at the right subchondral region of the acetabulum using magnetic resonance imaging (MRI). Although the patient had no obvious risk factors associated with bone fragility, his bone mineral density measured using dual X-ray absorptiometry indicated severe osteoporosis (lumber spine: T score - 3.4 standard deviation [SD]; femoral neck: T score - 2.8 SD). Serum 25-hydroxyvitamin D level was deficient (19 ng/mL), which was considered to be partly due to non-sunlight exposure for 3 years owing to social withdrawal. Bilateral osteosynthesis was performed, considering his young age, although more than 2 weeks had passed since the onset of the fracture. Bone union and non-occurrence of osteonecrosis of the femoral head were confirmed via radiography and MRI 8 months after the surgery. CONCLUSIONS: Our case suggests that simultaneous non-traumatic bilateral femoral neck fractures can occur in healthy young men.


Subject(s)
Femoral Neck Fractures/surgery , Fracture Fixation, Internal/methods , Fractures, Spontaneous/surgery , Osteoporosis/diagnosis , Absorptiometry, Photon , Adult , Bone Density , Femoral Neck Fractures/diagnosis , Femoral Neck Fractures/etiology , Femur Neck/diagnostic imaging , Femur Neck/injuries , Femur Neck/surgery , Fractures, Spontaneous/diagnosis , Fractures, Spontaneous/etiology , Humans , Magnetic Resonance Imaging , Male , Osteoporosis/blood , Osteoporosis/complications , Time-to-Treatment , Vitamin D/analogs & derivatives , Vitamin D/blood
7.
AJR Am J Roentgenol ; 210(3): 601-607, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29336599

ABSTRACT

OBJECTIVE: The objective of this study is to formulate a new MRI classification system for fatigue-type femoral neck stress injuries (FNSIs) that is based on patient management and return-to-duty (RTD) time. MATERIALS AND METHODS: A retrospective review of 156 consecutive FNSIs in 127 U.S. Army soldiers over a 24-month period was performed. The width of marrow edema for low-grade FNSIs and the measurement of macroscopic fracture as a percentage of femoral neck width for high-grade FNSIs were recorded. RTD time was available for 90 soldiers. Nonparametric testing, univariate linear regression, and survival analysis on RTD time were used in conjunction with patient management criteria to develop a new FNSI MRI classification system. RESULTS: The FNSI incidence was 0.09%, and all FNSIs were compressive-sided injuries. RTD time was significantly longer for high-grade FNSIs versus low-grade FNSIs (p < 0.001). Our FNSI MRI classification system showed a significant difference in RTD time between grades 1 and 2 (p = 0.001-0.029), 1 and 3 (p < 0.001), and 1 and 4 (p = 0.001-0.01). There was no significant RTD time difference between the remaining grades. The rates of completing basic training (BT) and requiring medical discharge were significantly associated with the FNSI MRI grades (p = 0.038 and p = 0.001, respectively). CONCLUSION: The proposed FNSI MRI classification system provides a robust framework for patient management optimization by permitting differentiation between operative and nonoperative candidates, by allowing accurate prediction of RTD time, and by estimating the risk of not completing BT and requiring medical discharge from the military.


Subject(s)
Femoral Fractures/classification , Femoral Fractures/diagnostic imaging , Femur Neck/diagnostic imaging , Femur Neck/injuries , Fractures, Stress/classification , Fractures, Stress/diagnostic imaging , Magnetic Resonance Imaging/methods , Military Personnel , Adolescent , Adult , Female , Femoral Fractures/epidemiology , Fractures, Stress/epidemiology , Humans , Incidence , Male , Retrospective Studies , United States/epidemiology
8.
Mod Rheumatol ; 24(1): 172-81, 2014 Jan.
Article in English | MEDLINE | ID: mdl-24261775

ABSTRACT

OBJECTIVES: This study aimed to evaluate the relationship between radiographic knee osteoarthritis and vertebral fractures (VFs) in an Asian population. METHODS: This cross-sectional study involved data from 1,829 participants of the Fifth Korean National Health and Nutrition Examination Survey. Radiographic knee osteoarthritis was defined as Kellgren-Lawrence (KL) grades ≥ 2. Prevalent VF was defined as a loss of ≥ 4 cm of height from the peak height. BMD was measured using dual-energy X-ray absorptiometry, in the lumbar spine and femoral neck. RESULTS: In both sexes, the prevalence of VFs increased with age, and was higher in the knee osteoarthritis group than in the control group (in men 13.2 % in osteoarthritis group and 7.9 % in control group; in women 27.7 % in osteoarthritis group and 14.7 % in control group). Age-adjusted BMD at the lumbar spine and femoral neck was significantly higher in the knee osteoarthritis group. In multivariable analysis, KL grade 4 was significantly associated with vertebral fractures in men. In women, there was a significant trend for a positive association between KL grades and vertebral fractures. CONCLUSIONS: Despite high systemic BMD, knee osteoarthritis was positively associated with VFs. These results suggest that bone quality, and consequently bone strength, may be decreased at the systemic level in knee osteoarthritis.


Subject(s)
Bone Density/physiology , Femur Neck/injuries , Lumbar Vertebrae/injuries , Osteoarthritis, Knee/epidemiology , Spinal Fractures/epidemiology , Aged , Aged, 80 and over , Asian People , Cross-Sectional Studies , Female , Femur Neck/diagnostic imaging , Humans , Lumbar Vertebrae/diagnostic imaging , Male , Middle Aged , Osteoarthritis, Knee/diagnostic imaging , Prevalence , Radiography , Risk Factors , Spinal Fractures/diagnostic imaging
9.
Arthroscopy ; 29(10): 1608-14, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23993057

ABSTRACT

PURPOSE: To investigate the effect of femoral cortical notching at different depths on the peak compressive load and energy required to cause a femoral neck fracture in composite femurs. METHODS: Thirty fourth-generation composite femurs were divided into 5 groups: (1) intact with an inherent alpha angle of 61°, (2) resection of inherent cam lesion by reducing the alpha angle from 61° to 45°, (3) cam resection and cortical notching of a 5.5-mm spherical diameter by 2.00-mm (grade I) depth, (4) cam resection with cortical notching of 4.00-mm (grade II) depth, and (5) cam resection with cortical notching of 6.00-mm (grade III) depth. The specimens were loaded in the position of midstance during gait and tested until failure using a dynamic tensile testing machine at a rate of 6 mm/min. RESULTS: Grade II and grade III cortical notching depths with cam resections resulted in a significant decrease in the ultimate load to failure and energy (P < .05) compared with the intact state. The grade II and grade III cortical notching groups with cam resection failed at a significantly lower ultimate load and with significantly lower energy when compared with the cam resection group alone. CONCLUSIONS: The findings of this study demonstrated significant decreases in ultimate load and energy to failure between the intact group and the grade II and grade III femoral cortical notching groups with cam resection. CLINICAL RELEVANCE: Iatrogenic cortical notching may lead to an increased risk of postsurgical complications, specifically femoral neck fracture. Thus, surgical intervention for a cam lesion femoral osteoplasty should strive for precision, especially around the femoral neck.


Subject(s)
Compressive Strength/physiology , Femoral Neck Fractures/etiology , Femur Neck/injuries , Iatrogenic Disease , Materials Testing/methods , Analysis of Variance , Biomechanical Phenomena , Femur/anatomy & histology , Femur Neck/surgery , Humans , Materials Testing/instrumentation
10.
J Arthroplasty ; 28(8): 1386-90, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23535286

ABSTRACT

The objective of this study was to evaluate the most common treatments performed for hip fractures over the last decade in the United States. The leading treatment for trochanteric fractures was internal fixation, accounting for 96%-98% of surgical treatments each year. For cervical fractures, hemiarthroplasty (HA), total hip arthroplasty (THA), and internal fixation were performed nearly 61%, 5%, and 33% of the time, respectively, each year without any sign of change during the period assessed. The surgical choice for cervical fractures varied greatly by patient age. In 2009, two-thirds of patients younger than 60 years underwent internal fixation while two-thirds of patients 60 years or older underwent HA. Regardless of patient age, HA was performed more often than THA for cervical hip fractures.


Subject(s)
Arthroplasty, Replacement, Hip/trends , Femoral Fractures/surgery , Fracture Fixation, Internal/trends , Hemiarthroplasty/trends , Adult , Age Factors , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/methods , Arthroplasty, Replacement, Hip/statistics & numerical data , Femoral Fractures/epidemiology , Femoral Neck Fractures/epidemiology , Femoral Neck Fractures/surgery , Femur/injuries , Femur/surgery , Femur Neck/injuries , Femur Neck/surgery , Fracture Fixation, Internal/methods , Fracture Fixation, Internal/statistics & numerical data , Hemiarthroplasty/methods , Hemiarthroplasty/statistics & numerical data , Hip Fractures/epidemiology , Hip Fractures/surgery , Humans , Middle Aged , Retrospective Studies , Treatment Outcome , United States/epidemiology
11.
BMC Musculoskelet Disord ; 13: 177, 2012 Sep 20.
Article in English | MEDLINE | ID: mdl-22992273

ABSTRACT

BACKGROUND: Low bone mineral density (BMD) and subsequent fractures are a major public health problem in postmenopausal women. The purpose of this study was to use the aggregate data meta-analytic approach to examine the effects of ground (for example, walking) and/or joint reaction (for example, strength training) exercise on femoral neck (FN) and lumbar spine (LS) BMD in postmenopausal women. METHODS: The a priori inclusion criteria were: (1) randomized controlled trials, (2) exercise intervention ≥ 24 weeks, (3) comparative control group, (4) postmenopausal women, (5) participants not regularly active, i.e., less than 150 minutes of moderate intensity (3.0 to 5.9 metabolic equivalents) weight bearing endurance activity per week, less than 75 minutes of vigorous intensity (> 6.0 metabolic equivalents) weight bearing endurance activity per week, resistance training < 2 times per week, (6) published and unpublished studies in any language since January 1, 1989, (7) BMD data available at the FN and/or LS. Studies were located by searching six electronic databases, cross-referencing, hand searching and expert review. Dual selection of studies and data abstraction were performed. Hedge's standardized effect size (g) was calculated for each FN and LS BMD result and pooled using random-effects models. Z-score alpha values, 95%confidence intervals (CI) and number-needed-to-treat (NNT) were calculated for pooled results. Heterogeneity was examined using Q and I2. Mixed-effects ANOVA and simple meta-regression were used to examine changes in FN and LS BMD according to selected categorical and continuous variables. Statistical significance was set at an alpha value ≤0.05 and a trend at >0.05 to ≤ 0.10. RESULTS: Small, statistically significant exercise minus control group improvements were found for both FN (28 g's, 1632 participants, g = 0.288, 95% CI = 0.102, 0.474, p = 0.002, Q = 90.5, p < 0.0001, I2 = 70.1%, NNT = 6) and LS (28 g's, 1504 participants, g = 0.179, 95% CI = -0.003, 0.361, p = 0.05, Q = 77.7, p < 0.0001, I2 = 65.3%, NNT = 6) BMD. Clinically, it was estimated that the overall changes in FN and LS would reduce the 20-year relative risk of osteoporotic fracture at any site by approximately 11% and 10%, respectively. None of the mixed-effects ANOVA analyses were statistically significant. Statistically significant, or a trend for statistically significant, associations were observed for changes in FN and LS BMD and 20 different predictors. CONCLUSIONS: The overall findings suggest that exercise may result in clinically relevant benefits to FN and LS BMD in postmenopausal women. Several of the observed associations appear worthy of further investigation in well-designed randomized controlled trials.


Subject(s)
Bone Density , Femur Neck/pathology , Lumbar Vertebrae/pathology , Osteoporosis, Postmenopausal/therapy , Resistance Training , Walking , Aged , Analysis of Variance , Biomechanical Phenomena , Female , Femoral Neck Fractures/etiology , Femoral Neck Fractures/pathology , Femoral Neck Fractures/prevention & control , Femur Neck/diagnostic imaging , Femur Neck/injuries , Femur Neck/physiopathology , Humans , Lumbar Vertebrae/diagnostic imaging , Lumbar Vertebrae/injuries , Lumbar Vertebrae/physiopathology , Middle Aged , Osteoporosis, Postmenopausal/complications , Osteoporosis, Postmenopausal/diagnostic imaging , Osteoporosis, Postmenopausal/pathology , Osteoporosis, Postmenopausal/physiopathology , Postmenopause , Radiography , Randomized Controlled Trials as Topic , Spinal Fractures/etiology , Spinal Fractures/pathology , Spinal Fractures/prevention & control , Treatment Outcome
14.
J Endocrinol Invest ; 34(11): e386-91, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21750394

ABSTRACT

The aim of the study was to estimate the absolute risk of fracture in a sample of postmenopausal women with the Italian version of FRAX®, using femoral neck bone mineral density (BMD) and 3 internationally validated clinical risk factors (CRFs) (history of fragility fracture, family history of hip fracture, current smoking). We retrospectively studied 9586 women (mean age 64.1 yr) examined in three osteoporosis centers from Northern Italy over two years (2001-2002). The risk of major osteoporotic (clinical spine, hip, forearm and humerus) and hip fractures was estimated using the online version of the FRAX algorithm adapted for Italy. The median 10-year risk was 7.5% for osteoporotic fracture and 1.7% for hip fracture. 25% of subjects had a 10-year risk ≥ 12.1% for osteoporotic fracture and ≥ 4.1% for hip fracture. The median 10-year risk of fracture increased with the number of prevalent CRFs. For major osteoporotic fractures risk rose from 6.3% to 10.9%, 21.4% and 40.9% with 1, 2 and 3 prevalent CRFs, respectively. For hip fractures the corresponding figures were: 1.3%, 2.7%, 7.0% and 21.9%, respectively. However, it must be emphasized that in 2 out of 3 women, none of the CRFs examined was present and the assessment of risk was limited to age and BMD. Our data provide the first description of the effect of the combination of BMD, age and CRFs on fracture risk stratification in a large sample of Italian postmenopausal women using FRAX®. The results are a useful starting point to define criteria for the application of FRAX® in clinical practice in Italy.


Subject(s)
Femur Neck , Osteoporosis, Postmenopausal/diagnosis , Osteoporosis, Postmenopausal/epidemiology , Osteoporotic Fractures/diagnosis , Osteoporotic Fractures/epidemiology , Aged , Aged, 80 and over , Bone Density/physiology , Cross-Sectional Studies , Female , Femur Neck/injuries , Femur Neck/pathology , Hip Fractures/diagnosis , Hip Fractures/epidemiology , Hip Fractures/etiology , Humans , Italy/epidemiology , Middle Aged , Osteoporosis, Postmenopausal/complications , Osteoporotic Fractures/etiology , Retrospective Studies , Risk Assessment/methods , Risk Assessment/trends , Risk Factors
15.
J Arthroplasty ; 26(6): 976.e1-5, 2011 Sep.
Article in English | MEDLINE | ID: mdl-20875944

ABSTRACT

Metal-on-metal bearing surfaces in total hip arthroplasty have been recently shown to have acceptable survivorship properties (J Bone Joint Surg Am. 2006;88:1183; J Bone Joint Surg Am. 2006;88:1173), and they have certain advantages and disadvantages when compared to conventional metal-on-polyethylene bearing surfaces. Like traditional metal-on-polyethylene bearings, these metal-on-metal implants may also suffer from catastrophic failure. This case report represents an unusual situation in a 57-year-old man in which dissociation of a metal inlay in a metal-on-metal total hip arthroplasty resulted in articulation of the inferior aspect of the inlay with the femoral neck, leading to femoral neck notching, extensive periprosthetic soft tissue metallosis, osteolysis, and subsequent prosthetic catastrophic failure.


Subject(s)
Arthroplasty, Replacement, Hip/instrumentation , Hip Prosthesis/adverse effects , Inlays/adverse effects , Metals/adverse effects , Osteoarthritis, Hip/surgery , Prosthesis Failure/etiology , Acetabulum/diagnostic imaging , Acetabulum/surgery , Arthroplasty, Replacement, Hip/methods , Femur Neck/injuries , Hip Joint/diagnostic imaging , Hip Joint/surgery , Humans , Male , Middle Aged , Osteolysis/etiology , Prosthesis Design , Radiography , Reoperation
16.
Int Orthop ; 35(7): 1083-8, 2011 Jul.
Article in English | MEDLINE | ID: mdl-20711725

ABSTRACT

Out of 52 cases of ipsilateral femoral fractures treated at a level I trauma centre between June 1994 and March 2008, the diaphyseal fracture was accompanied by a intracapsular neck fracture in only 20 cases. In the rest of the cases, the diaphyseal fracture was combined with either an extracapsular or pertrochanteric fracture. Five of these patients also had fractures of the distal femur. In three of those patients we began treatment with osteosynthesis of the femoral neck and shaft, using a reconstruction nail, then stabilized the distal fracture with a 95° blade plate or with lag screws. In the other two cases, initial treatment dealt with the distal femoral fracture, stabilizing it with a 95° blade plate, which was also used for stabilization of the diaphyseal fracture. In these patients, the proximal fracture was treated using dynamic hip screws (DHS). All fractures healed, two after initial treatment, while the other three needed one reoperation. The follow-up period was 2-13 years after the injury. The order in which fractures are treated is best left to the discretion of the physician and the circumstances. In our experience, two implants are sufficient for osteosynthesis, one for stabilizing one end of the femur together with the shaft, and the other is used for treating the other end of the femur.


Subject(s)
Femoral Neck Fractures/surgery , Femur Head/injuries , Femur Neck/injuries , Fracture Fixation, Internal , Accidents, Traffic , Adult , Bone Nails , Bone Plates , Bone Screws , Female , Femoral Neck Fractures/physiopathology , Femur Head/surgery , Femur Neck/surgery , Follow-Up Studies , Fracture Fixation, Internal/instrumentation , Fracture Fixation, Internal/methods , Fracture Healing , Humans , Male , Middle Aged , Multiple Trauma , Trauma Severity Indices
17.
Medicine (Baltimore) ; 100(4): e23616, 2021 Jan 29.
Article in English | MEDLINE | ID: mdl-33530163

ABSTRACT

RATIONALE: Pediatric femoral shaft combined with ipsilateral femoral neck fractures are very rare but challenging injuries fraught with the development of avascular necrosis, coxa vara, and leg length discrepancy. Majority of the previous reports indicated the neck femur fracture was fixed with cannulated screws or/and pins, femoral shaft fracture was stabilized with a plate and screws. However, we used cannulated screws combined with elastic stable intramedullary nails to minimally invasive procedures treat this type of injury and achieved good follow-up results. PATIENT CONCERNS: A 7-year-old boy (Case 1) was hospitalized due to a traffic accident resulting in swelling and deformity of the right thigh accompanied by limited mobility of hip and knee. A 5-year-old male child (Case 2) presented with pain and swelling in the bilateral lower limb after fall from approximately 12 feet. DIAGNOSES: Physical examination, X-ray film, and computed tomography were performed. Both patients were diagnosed with ipsilateral femoral neck and shaft fracture. INTERVENTIONS: The fractures were reduced closed by image-intensifier imaging. Two partially threaded cancellous screws were used to fix femoral neck fracture, and elastic intramedullary nails were performed to stable the femoral shaft fracture. Postoperatively, the patients were immobilized in a one-and-a-half hip spica cast for six weeks. The internal fixations were removed after one year. OUTCOMES: Case one was follow-up at 14 months and the other one was followed up for 3 years. And at the last follow-up showed a normal and painless hip function. No clinical complications were found during follow-up visit, including head penetration, implant failure, fracture nonunion, avascular necrosis and hip varus deformity. LESSONS: Clinician should carefully check and read relevant imaging data to avoid missed diagnosis. And the internal fixation method described in this paper may be more minimally invasive.


Subject(s)
Femoral Fractures/surgery , Femoral Neck Fractures/surgery , Femur Neck/injuries , Fracture Fixation, Intramedullary/methods , Bone Nails , Bone Plates , Bone Screws , Child , Child, Preschool , Femur Neck/surgery , Humans , Male
18.
Proc Inst Mech Eng H ; 224(3): 427-39, 2010.
Article in English | MEDLINE | ID: mdl-20408488

ABSTRACT

Hip resurfacing is an established treatment for osteoarthritis in young active patients. Failure modes include femoral neck fracture and prosthesis loosening, which may be associated with medium-term bone adaptation, including femoral neck narrowing and densification around the prosthesis stem. Finite element modelling was used to indicate the effects of prosthesis sizing and positioning on the bone remodelling and fracture strength under a range of normal and traumatic loads, with the aim of understanding these failure modes better. The simulations predicted increased superior femoral neck stress shielding in young patients with small prostheses, which required shortening of the femoral neck to give an acceptable implant-bone interface. However, with a larger prosthesis, natural femoral head centre recreation in the implanted state was possible; therefore stress shielding was restricted to the prosthesis interior, and its extent was less sensitive to prosthesis orientation. With valgus orientation, the implanted neck strength was, at worst, within 3 per cent of its intact strength. The study suggests that femoral neck narrowing may be linked to a reduction in the horizontal femoral offset, occurring if the prosthesis is excessively undersized. As such, hip resurfacing should aim to reproduce the natural femoral head centre, and, for valgus prosthesis orientation, to avoid femoral neck fracture.


Subject(s)
Arthroplasty, Replacement, Hip/adverse effects , Bone Remodeling , Femoral Neck Fractures/etiology , Femoral Neck Fractures/physiopathology , Hip Prosthesis/adverse effects , Models, Biological , Prosthesis Failure , Computer Simulation , Equipment Failure Analysis , Femur Neck/injuries , Femur Neck/physiopathology , Humans
19.
Int Orthop ; 34(5): 631-4, 2010 Jun.
Article in English | MEDLINE | ID: mdl-19506866

ABSTRACT

We prospectively examined the functional and radiographic outcomes of a serial cohort of 104 Birmingham Hip Resurfacings in an independent centre. Final follow-up was to a mean of 61 months, and six cases were lost to follow-up. Excellent results were obtained in 91%, but obese patients had significantly (p < 0.03) poorer post-operative outcomes. Whilst there were no cases of neck fracture neck narrowing of up to 20 mm was noted. Radiolucent lines were present in a single zone in 9.4% (9/96) acetabular and 3.1% (3/96) femoral components. However, no components were definitely loose and there were no revisions for any reason during the period of the study. This independent series confirms that the Birmingham Hip Resurfacing gives excellent early clinical results and little early evidence of radiographic failure. The high rate of neck narrowing gives us cause for concern and we would recommend regular radiographic follow-up.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Hip Joint/surgery , Hip Prosthesis , Osteoarthritis, Hip/surgery , Adult , Aged , Arthroplasty, Replacement, Hip/adverse effects , Arthroplasty, Replacement, Hip/instrumentation , Female , Femur Neck/diagnostic imaging , Femur Neck/injuries , Follow-Up Studies , Hip Joint/diagnostic imaging , Humans , Male , Middle Aged , Obesity/complications , Osteoarthritis, Hip/diagnostic imaging , Prospective Studies , Prosthesis Design , Prosthesis Failure , Radiography , Reoperation , Risk Factors , Treatment Outcome
20.
Orthop Traumatol Surg Res ; 106(1S): S79-S87, 2020 02.
Article in English | MEDLINE | ID: mdl-31680016

ABSTRACT

Proximal femur fractures have significant functional repercussions in both older adults (sometimes life-threatening) and younger adults (socioeconomic). This study will review the early mechanical complications (EMC) associated with the fixation of femoral neck (FNF) and trochanteric (TF) fractures. What is the nature of these complications? They consist of incorrect fracture fixation, secondary displacement and/or fixation failure (FNF: 3-10%; TF: 5-7%), and more rarely, secondary fractures distal to the implant. What are the risk factors and how can they be controlled? They are related to the patient (osteoporosis), to the type of fracture (FNF: posterior comminution, magnitude of displacement, vertical fracture line, fracture of calcar/TF: comminution of calcar, lesser trochanter fracture, metaphyseal comminution, lateral cortex fracture, greater trochanter comminution), to the chosen treatment (FNF: triple screw fixation or screw-plate are preferable/TF: all implants suitable for simple fractures, cervicomedullary implants for complex fractures), and to the surgical technique (quality of reduction, implant positioning). How should they be treated? Early revision of internal fixation can be difficult and increases the infection risk. Inter- or subtrochanteric valgus osteotomy leads to satisfactory results but is difficult to carry out. Secondary arthroplasty, which is the preferred option in older adults, leads to good outcomes but is technically more difficult, and has a higher complication rate in EMC of trochanteric fractures. LEVEL OF EVIDENCE: V.


Subject(s)
Bone Plates/adverse effects , Bone Screws/adverse effects , Femoral Fractures/surgery , Fracture Fixation, Internal/adverse effects , Postoperative Complications/prevention & control , Femoral Fractures/diagnosis , Femur Neck/diagnostic imaging , Femur Neck/injuries , Femur Neck/surgery , Hip Fractures/surgery , Humans , Time Factors
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