1.
Nat Clin Pract Oncol
; 5(4): 234-8, 2008 Apr.
Article
in English
| MEDLINE
| ID: mdl-18285762
ABSTRACT
BACKGROUND: A 75-year-old man on methotrexate immunosuppression for myasthenia gravis presented with a 2-month history of lymphocytosis and bilateral inguinal adenopathy. There were no constitutional symptoms of fever, night sweats, or weight loss. INVESTIGATIONS: Physical examination, blood tests, flow cytometry, fluorescent in situ hybridization, immunoglobulin gene sequencing, viral load quantification by real-time polymerase chain reaction, excisional lymph-node biopsy, bone-marrow biopsy, tumor morphology and immunohistochemistry, sequential CT and PET scans. DIAGNOSIS: Methotrexate-associated mantle-cell lymphoma. MANAGEMENT: Cessation of methotrexate, anthracycline-based combination chemo-immunotherapy, and maintenance rituximab.
Subject(s)
Immunosuppressive Agents/adverse effects , Lymphoma, Mantle-Cell/chemically induced , Methotrexate/adverse effects , Myasthenia Gravis/drug therapy , Aged , Diagnosis, Differential , Humans , Immunosuppressive Agents/administration & dosage , Lymphocytes , Lymphocytosis/chemically induced , Lymphoma, Mantle-Cell/diagnosis , Lymphoma, Mantle-Cell/etiology , Male , Methotrexate/administration & dosage , Risk Factors
2.
Leukemia
; 20(5): 891-3, 2006 May.
Article
in English
| MEDLINE
| ID: mdl-16525491