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1.
Ophthalmic Plast Reconstr Surg ; 39(3): 293-296, 2023.
Article in English | MEDLINE | ID: mdl-36877568

ABSTRACT

PURPOSE: Sensory alterations of the upper eyelid skin and eyelashes are frequently encountered after upper eyelid surgery. The objective of this study was to provide information on the exact course and distribution of sensory nerve fibers through the anatomic planes in the upper eyelid. METHODS: Ten formalin-fixed hemifaces were dissected. The nerve branches of the ophthalmic nerve in the upper eyelid were traced in an anterograde fashion. RESULTS: A total of 151 nerve fibers were recorded during dissection. The infratrochlear, supratrochlear, supraorbital, and lacrimal nerve contributed each to both the upper eyelid skin innervation and the upper eyelid rim plexus in different distribution patterns. The mean distance from the eyelid margin at which nerve fibers pierced from preseptal into the orbicularis muscle was 14 ± 1.1 mm for nerve fibers targeting the eyelid dermis and 3.7 ± 1.2 mm for nerve fibers targeting the eyelid rim plexus ( p < 0.001). The mean intraorbicular course of nerve fibers was 3 mm (0-17; standard deviation 4.1). The mean distance from the eyelid margin at which nerve fibers pierced from the orbicularis muscle into the preorbicular plane was 10 ± 1 mm for nerve fibers innervating the eyelid dermis and 1.3 ± 0.8 mm for nerve fibers innervating the eyelid rim plexus ( p < 0.001). The mean distance of the preorbicular course of nerve fibers was 2 mm (0-15; standard deviation 3.6). CONCLUSIONS: Based on the findings, a certain degree of postoperative eyelid skin numbness is inevitable while eyelash innervation may be spared in upper blepharoplasty.


Subject(s)
Blepharoplasty , Eyelids , Humans , Eyelids/surgery , Eyelids/physiology , Ophthalmic Nerve/surgery , Muscles/surgery , Hypesthesia
2.
Pain Pract ; 21(1): 26-36, 2021 01.
Article in English | MEDLINE | ID: mdl-32585754

ABSTRACT

OBJECTIVE: To evaluate risk factors associated with recurrence after radiofrequency thermocoagulation (RFT) of the gasserian ganglion among patients with ophthalmic trigeminal neuralgia (TN) and prognostic factors in terms of recurrence-free survival (RFS) during a long-term follow-up. METHODS: From January 2005 to December 2017, 300 patients with ophthalmic TN underwent RFT. A retrospective analysis of 14-year outcomes was performed. Kaplan-Meier analysis was used for RFS after the procedure. Univariate and multivariate Cox regression analyses were performed to identify risk factors for pain recurrence. RESULTS: The initial effective rate of RFT for ophthalmic TN was 92%. The mean follow-up time was 77.38 ± 43.24 months. The cumulative probability of RFS was 86.94% at 1 year, 80.03% at 2 years, 77.27% at 3 years, 74.01% at 5 years, and 59.92% at 10 years after RFT. The mean duration of RFS was 114.67 months (95% confidence interval [CI] 106.27 to 123.06 months). In multivariate analysis, atypical pain (hazard ratio [HR] = 2.831, 95% CI 1.759 to 4.554, P < 0.001) and mild facial hypesthesia (HR = 2.540, 95% CI 1.309 to 4.931, P = 0.006) before RFT were independently associated with pain recurrence. Patients with a prognostic index (PI) > 1.27 were at high risk for pain recurrence. Major complications included troublesome dysesthesia (0.7%), keratitis (10.9%), diplopia (0.4%), facial paresthesia (6.2%), and masseter weakness (12.7%). Masseter weakness was more common in patients with V3 branch involvement. Three patients lost their sight due to keratitis. CONCLUSION: Our study investigated long-term outcomes and complications of RFT for ophthalmic TN. Patients at high risk for pain recurrence were identified, which might provide a basis for clinical decision making before RFT.


Subject(s)
Catheter Ablation/methods , Electrocoagulation/methods , Trigeminal Ganglion/surgery , Trigeminal Neuralgia/surgery , Aged , Aged, 80 and over , Catheter Ablation/adverse effects , Electrocoagulation/adverse effects , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Ophthalmic Nerve/pathology , Ophthalmic Nerve/surgery , Pain Management/adverse effects , Pain Management/methods , Prognosis , Recurrence , Retrospective Studies
3.
Neurosurg Rev ; 43(2): 555-564, 2020 Apr.
Article in English | MEDLINE | ID: mdl-30483973

ABSTRACT

To evaluate the safety and efficacy of intradural "limited drill" technique (ILDT) of anterior clinoidectomy (AC) and optic canal unroofing (OCU) for microneurosurgical management of ophthalmic segment and posterior communicating artery (PCOM) aneurysms. All the patients with ophthalmic segment and PCOM aneurysms who underwent AC and OCU by ILDT for microneurosurgical management of ophthalmic segment and PCOM aneurysms during 4-year period (2013-2016) at our Institute were included in this study. In ILDT of AC and OCU, the use of power drill is restricted to AC only and OCU is done exclusively with 1-mm Kerrison punch. AC and OCU by ILDT were done in 24 patients with 29 ophthalmic segment and 7 PCOM aneurysms. AC and OCU by ILDT helped in mobilization of optic nerve/internal carotid artery (ICA) and provided excellent exposure for all these aneurysms. There was no injury to ICA or optic nerve during drilling. AC and OCU facilitated clip ligation of 34 of these aneurysms. Remaining 2 aneurysms were considered not suitable for clipping. Check angiogram done for 33 aneurysms revealed complete obliteration of 26 aneurysms, very small residual neck in 5 aneurysms, and small residual aneurysm in 2 aneurysms. Deterioration in vision was noted in 1 patient (4.1%). In 6 patients with preoperative visual deficits, significant improvement in vision was noted in 4 patients (4/6-66.6%) after surgery. Good outcome (MRS < 2) was noted in 91.6% (22/24) of these patients. ILDT is a safe and effective technique of AC and OCU which provide good exposure for ophthalmic segment and PCOM aneurysms.


Subject(s)
Anterior Cerebral Artery/surgery , Carotid Artery, Internal/surgery , Intracranial Aneurysm/surgery , Microsurgery/instrumentation , Microsurgery/methods , Neurosurgical Procedures/instrumentation , Neurosurgical Procedures/methods , Ophthalmic Nerve/surgery , Optic Nerve/surgery , Sphenoid Bone/surgery , Adult , Aged , Cerebral Angiography , Female , Humans , Intracranial Aneurysm/complications , Intracranial Aneurysm/diagnostic imaging , Magnetic Resonance Imaging , Male , Middle Aged , Postoperative Complications/epidemiology , Surgical Instruments , Treatment Outcome , Vision Disorders/etiology
4.
Curr Opin Ophthalmol ; 30(4): 292-298, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31033738

ABSTRACT

PURPOSE OF REVIEW: Neurotrophic keratopathy is a devastating corneal condition that can lead to ocular morbidity and blindness. Current medical and surgical treatments poorly tackle the essential problem of corneal aesthesia and hence fail to provide a permanent cure. Recent advances in corneal neurotization techniques have shown promise to restore corneal nerves in neurotrophic keratopathy. This article aims at reviewing the current surgical advances, along with the current thoughts and evidence available for corneal nerve regeneration. RECENT FINDINGS: Corneal neurotization was first introduced in 2009 by Terzis et al., but recently picked up more interest since 2014. Direct and indirect neurotization are being developed, and different nerves (sural nerve, great auricular nerve) have been explored for interposition between frontal nerve branches and the cornea. New endoscopic techniques are introduced for less invasive approaches. On the corneal front, confocal microscopy and esthesiometry studies have established that the regeneration of the corneal nerves is happening 6 months after the procedure. SUMMARY: Neurotization is a budding revolutionary technique that shows promise of cure for neurotrophic corneas, but at this stage, it is still reasonably invasive and still reserved for selected patients.


Subject(s)
Cornea/innervation , Corneal Diseases/surgery , Nerve Transfer/methods , Ophthalmic Nerve/surgery , Cornea/surgery , Corneal Diseases/physiopathology , Humans , Microscopy, Confocal , Nerve Regeneration/physiology , Ophthalmic Nerve/physiopathology , Ophthalmologic Surgical Procedures/methods
5.
Ophthalmic Plast Reconstr Surg ; 35(2): 133-140, 2019.
Article in English | MEDLINE | ID: mdl-30059392

ABSTRACT

PURPOSE: To describe a minimally invasive surgical technique and its clinical outcomes with the use of acellular nerve allograft to re-establish corneal sensibility in patients with neurotrophic keratopathy. METHODS: Acellular nerve allograft was coapted to an intact supraorbital, supratrochlear, or infraorbital nerve and transferred to the affected eye. Donor nerve pedicles were isolated through a transpalpebral or transconjunctival approach. Retrospective evaluation of preoperative and postoperative corneal sensibility, ocular surface, and best-corrected visual acuity was performed in all patients. Mean follow-up period was 6 months (range: 3-10 months). RESULTS: Corneal neurotization with acellular nerve allograft was successfully performed in 7 patients with restoration of corneal sensibility and corneal epithelial integrity. In vivo confocal microscopy demonstrated increased nerve density in corneal stroma at 4 months after surgery. CONCLUSIONS: The use of acellular nerve allograft allows for a minimally invasive approach to successful corneal neurotization.


Subject(s)
Cornea/innervation , Corneal Diseases/surgery , Minimally Invasive Surgical Procedures/methods , Nerve Transfer/methods , Ophthalmic Nerve/surgery , Ophthalmologic Surgical Procedures/methods , Adolescent , Adult , Aged , Allografts , Child , Cornea/diagnostic imaging , Cornea/surgery , Corneal Diseases/diagnosis , Female , Follow-Up Studies , Humans , Male , Microscopy, Confocal , Middle Aged , Nerve Regeneration , Retrospective Studies , Treatment Outcome , Young Adult
6.
Ophthalmic Plast Reconstr Surg ; 34(1): 82-85, 2018.
Article in English | MEDLINE | ID: mdl-29194285

ABSTRACT

PURPOSE: The authors describe a minimally invasive surgical technique to re-establish corneal sensibility in a patient with neurotrophic keratopathy with the supraorbital nerve harvested endoscopically. METHODS: Pedicled contralateral supraorbital nerve was harvested endoscopically through small eyelid crease and scalp incisions and transferred to the affected eye. RESULTS: Endoscopic corneal neurotization was successfully performed with restoration of corneal sensibility and corneal epithelial integrity. CONCLUSIONS: The use of an endoscope allows for a minimally invasive approach to successful corneal neurotization with the supraorbital nerve.


Subject(s)
Cornea/innervation , Corneal Diseases/surgery , Endoscopy/methods , Nerve Regeneration , Nerve Transfer/methods , Ophthalmic Nerve/surgery , Ophthalmologic Surgical Procedures/methods , Aged, 80 and over , Female , Humans , Ophthalmic Nerve/physiopathology
8.
Ophthalmic Plast Reconstr Surg ; 29(5): 403-8, 2013.
Article in English | MEDLINE | ID: mdl-23928468

ABSTRACT

BACKGROUND: This article elucidates the anatomical details of the course and territory of the supraorbital (SO) and supratrochlear (ST) nerves. Possible applications of the SO and ST nerves for sensory nerve transfer are also examined. METHODS: The dissection of 3 fresh cadaver heads (6 hemifaces) was performed. In each hemiface, the ST and SO nerves were identified. The following data were recorded: 1) number of branches, 2) skin boundaries, 3) communicative branches, and 4) branch length. The feasibility of specific nerve-transfer procedures was also examined. RESULTS: In 4 hemifaces the SO nerve exited from the SO notch and in 2 hemifaces from the SO foramen. The position was lateral to the midline, with a mean distance of 1.93 cm. In all dissections, a maximum of 4 SO branches (range 2-4) were identified. The ST nerve exited the orbital rim medial to the SO nerve, and lateral to the midline with a mean distance of 0.866 cm. The mean distance between the SO and ST nerves at the level of the SO rim was 1.06 cm. In 5 of 6 hemifaces, several sub-branches emerged from the main trunk of the ST nerve. In 1 hemiface the ST nerve was divided in 2 main branches. CONCLUSIONS: The data presented in the current study are in agreement with previous anatomical studies. Both ST and SO nerves can be used as sensory nerve donors in the head and neck area for numerous expanding applications.


Subject(s)
Cornea/innervation , Nerve Transfer , Ophthalmic Nerve/anatomy & histology , Orbit/innervation , Trochlear Nerve/anatomy & histology , Cadaver , Humans , Neurosurgical Procedures , Ophthalmic Nerve/surgery , Ophthalmologic Surgical Procedures , Trochlear Nerve/surgery
9.
Plast Reconstr Surg ; 152(2): 237e-247e, 2023 08 01.
Article in English | MEDLINE | ID: mdl-36727814

ABSTRACT

BACKGROUND: Sensory nerve tension and gliding-layer mobility in the brow may be significant factors affecting postoperative brow level in an endoscopic brow lift, yet they have rarely been studied. METHODS: To investigate the effects of sensory nerve tension and gliding-layer mobility, the following measurements were performed alongside the endoscopic brow lift in 50 fresh cadaveric hemifaces: amount of brow elevation, critical lifting amount (as sensory nerves became tense), laxity of sensory nerve courses, and mobility of brow-gliding layers. The sensory nerve situations in the subperiosteal and subgaleal dissections were also observed. RESULTS: Supraorbital nerve tension limited the cephalic advancement of the forehead flap. The mean elevation of the brow was 5.8 ± 1 mm (range, 3.5 to 8.6 mm). The mean critical lifting amount was 5.3 ± 1.1 mm (range, 4.0 to 7.3 mm). The mean amount of laxity in the supraorbital nerve (the permissible amount of lift) was 4.1 ± 0.9 mm (range, 2.5 to 5.5 mm). The galeal fat pad was responsible for 60% of brow mobility. The sensory nerve was more protected by a subgaleal dissection in the brow and inferior forehead and by a subperiosteal dissection in the middle and upper forehead. CONCLUSIONS: Cephalic movement of the forehead flap is limited by supraorbital nerve tension. The permitted lifting amount varies from 2.5 to 5.5 mm. Gliding-layer mobility in the brow offsets the postoperative amount of cephalic advancement of the forehead flap. Consideration of supraorbital nerve tension and gliding-layer mobility is recommended to obtain an optimal brow level in endoscopic brow lifts.


Subject(s)
Rhytidoplasty , Humans , Endoscopy , Eyebrows , Forehead/surgery , Ophthalmic Nerve/surgery
10.
Microsurgery ; 32(4): 309-13, 2012 May.
Article in English | MEDLINE | ID: mdl-22377779

ABSTRACT

BACKGROUND: The collected experience from facial allotransplantations has shown that the recovery of sensory function of the face graft is unpredictable. Unavailability of healthy donor nerves, especially in central face defects may contribute to this fact. Herein, the technical feasibility of transferring the supraorbitary nerve (SO) to the infraorbitary nerve (IO) in a model of central facial transplantation was investigated. METHODS: Five heads from fresh cadavers were dissected with the aid of 3× loupe magnification. Measurements of the maximum length of dissection of the SO nerve through a supraciliary incision and the IO nerve from the skin of the facial flap to the infraorbital foramen were performed. The distance between supraorbital and infraorbital foramens and the calibers of both nerves were also measured. In all dissections, we simulated a central allotransplantation procedure and assessed the feasibility of directly transferring the SO to the IO nerve. RESULTS: The average maximum length of dissection for the IO and SO nerve was 1.4 ± 0.3 cm and 4.5 ± 1.0 cm, respectively. The average distance between the infraorbital and supraorbital foramina was 4.6 ± 0.3 cm. The average calibers of the nerves were of 1.1 ± 0.2 mm for the SO nerve and 2.9 ± 0.4 mm for the IO nerve. We were able to perform tension-free SO to IO nerve coaptations in all specimens. CONCLUSION: SO to IO nerve transfer is an anatomically feasible procedure in central facial allotransplantation. This technique could be used to improve the restoration of midfacial sensation by the use of a healthy recipient nerve in case of the recipient IO nerves are not available secondary to high-energy trauma.


Subject(s)
Face/innervation , Facial Transplantation/methods , Nerve Transfer/methods , Ophthalmic Nerve/surgery , Sensation , Cadaver , Feasibility Studies , Female , Humans , Male
11.
J Neural Transm (Vienna) ; 118(11): 1571-4, 2011 Nov.
Article in English | MEDLINE | ID: mdl-21597942

ABSTRACT

Chronic daily headache (CDH) located in the frontal region is a common problem. We have previously described the positive results that were achieved with botulinum toxin (BTX) injections in the musculus corrugator supercilii (MCS) for this disorder. Nowadays, we offer transection of this muscle to patients following a minimum of two BTX injections, provided these injections result in a significant reduction of pain. This procedure is based on the assumption that the pathophysiological mechanism in some of these patients suffering from CDH is a neural entrapment of the supratrochlear nerve in the corrugator muscle. To assess the effect of transection, we have evaluated all the consecutive patients (n = 10) so far. Treatment was successful in nine of these patients. Prior to the treatment, the mean pain score in the 9 successfully treated patients was 8.1 (range 6-9), after transection this had been reduced to 0.8 (range 0-3). All of these successfully treated patients ceased their daily use of pain relief medication for their frontally localised headaches. Moreover, they stated that they would definitely undergo surgery, if they were to find themselves in the same situation again. Therefore, we conclude that transection of the MCS is an efficient and successful procedure for a carefully selected group of patients suffering from CDH in the frontal region. Most of all we intend to popularise this pathophysiological concept based on the distinct possibility that some headaches might be due to neural entrapment.


Subject(s)
Facial Muscles/surgery , Forehead/surgery , Headache Disorders/surgery , Nerve Compression Syndromes/surgery , Ophthalmic Nerve/surgery , Adolescent , Adult , Facial Muscles/anatomy & histology , Facial Muscles/physiopathology , Female , Follow-Up Studies , Forehead/anatomy & histology , Forehead/physiopathology , Headache Disorders/etiology , Headache Disorders/physiopathology , Humans , Male , Middle Aged , Nerve Compression Syndromes/etiology , Nerve Compression Syndromes/physiopathology , Ophthalmic Nerve/anatomy & histology , Ophthalmic Nerve/physiopathology , Young Adult
12.
Am J Ophthalmol ; 220: 203-214, 2020 12.
Article in English | MEDLINE | ID: mdl-32659280

ABSTRACT

PURPOSE: To analyze the comparative safety and efficacy of two techniques of corneal neurotization (CN) (direct corneal neurotization [DCN] vs indirect corneal neurotization [ICN]) for the treatment of neurotrophic keratopathy (NK). DESIGN: Multicenter interventional prospective comparative case series. METHODS: This study took place at ASST Santi Paolo e Carlo University Hospital, Milan; S.Orsola-Malpighi University Hospital, Bologna; and Santa Maria alle Scotte University Hospital, Siena, Italy. The study population consisted of consecutive patients with NK who underwent CN between November 2014 and October 2019. The intervention procedures included DCN, which was was performed by transferring contralateral supraorbital and supratrochlear nerves. ICN was performed using a sural nerve graft. The main outcome measures included NK healing, corneal sensitivity, corneal nerve fiber length (CNFL) measured by in vivo confocal microscopy (IVCM), and complication rates. RESULTS: A total of 26 eyes in 25 patients were included: 16 eyes were treated with DCN and 10 with ICN. After surgery, NK was healed in all patients after a mean period of 3.9 months without differences between DCN and ICN. Mean corneal sensitivity improved significantly 1 year after surgery (from 3.07 to 22.11 mm; P < .001) without differences between the 2 groups. The corneal sub-basal nerve plexus that was absent before surgery in all patients, except 4, become detectable in all cases (mean CNFL: 14.67 ± 7.92 mm/mm2 1 year postoperatively). No major complications were recorded in both groups. CONCLUSIONS: CN allowed the healing of NK in all patients as well as improvement of corneal sensitivity in most of them thanks to nerve regeneration documented by IVCM. One year postoperatively, DCN and ICN showed comparable outcomes.


Subject(s)
Cornea/innervation , Corneal Diseases/surgery , Nerve Regeneration , Nerve Transfer/methods , Ophthalmic Nerve/surgery , Adult , Aged , Aged, 80 and over , Corneal Diseases/diagnosis , Corneal Diseases/physiopathology , Female , Humans , Male , Microscopy, Confocal , Middle Aged , Prospective Studies , Treatment Outcome , Young Adult
13.
Acta Cytol ; 51(2): 207-10, 2007.
Article in English | MEDLINE | ID: mdl-17425205

ABSTRACT

BACKGROUND: Papillary endothelial hyperplasia (PEH) is an unusual form of thrombus organization that occurs predominantly in the extremities, including the head and neck. However, it is rare in the orbit/ocular region. Although the histologic features of PEH have been well described, the cytologic diagnosis remains difficult. CASE: A 63-year-old man presented with a left intraorbital mass that was increasing in size and associated with paresthesia and a recent history of excision of squamous cell carcinomas (SCC) from his left cheek. Fine needle aspiration biopsy (FNAB) yielded very limited material, predominantly blood. However, 1 Papanicolaou-stained slide showed groups of atypical cells with scanty but dense cytoplasm and large, hyperchromatic nuclei with prominent nucleoli. SCC was favored, and excision was performed. Histology showed PEH within an assumed cystic lymphangioma, associated with inflammatory and fibrotic change in the compressed supraorbital nerve. CONCLUSION: To our knowledge this is the third report on the cytology of PEH and the first report of FNAB in PEH of the orbit. The case was also unusual as it was the second metachronous PEH in the patient.


Subject(s)
Carcinoma, Squamous Cell/diagnosis , Endothelial Cells/pathology , Hyperplasia/pathology , Lymphangioma, Cystic/pathology , Orbital Neoplasms/pathology , Thrombosis/pathology , Biomarkers, Tumor/analysis , Biomarkers, Tumor/metabolism , Biopsy, Fine-Needle , Diagnosis, Differential , Humans , Hyperplasia/diagnostic imaging , Hyperplasia/physiopathology , Lymphangioma, Cystic/diagnostic imaging , Lymphangioma, Cystic/physiopathology , Male , Middle Aged , Ophthalmic Nerve/pathology , Ophthalmic Nerve/physiopathology , Ophthalmic Nerve/surgery , Ophthalmologic Surgical Procedures/methods , Orbital Neoplasms/diagnostic imaging , Orbital Neoplasms/physiopathology , Predictive Value of Tests , Thrombosis/etiology , Thrombosis/physiopathology , Tomography, X-Ray Computed , Treatment Outcome
14.
Rev Neurol ; 44(2): 89-91, 2007.
Article in Spanish | MEDLINE | ID: mdl-17236147

ABSTRACT

INTRODUCTION: Supraorbital neuralgia has only recently been described. Most of the cases reported involve patients suffering from chronic idiopathic neuralgias that are difficult to treat and sometimes require surgery to release the nerve. We present our experience in patients with a variant of this neuralgia which has a known causation, is commonly seen and has a benign prognosis. CASE REPORTS: We studied five patients, four females and one male, with a mean age of 55 years (range: 29-69 years). They had all suffered direct banal traumatic injury to the frontal region due to different causes. Four of them developed continuous, piercing or burning-type pain; three of them had paroxysmal pain and one had itching. There were no autonomic manifestations. All of them were found to be abnormally sensitive in the affected area, with tactile hypaesthesia, hyperalgesia or allodynia and a positive Tinel's sign. Neuroimaging tests were normal. Two patients were treated with gabapentin and amitriptyline. One was treated with an anaesthetic blockade, which afforded temporary relief. Three of them received no treatment at all. After one year of follow-up, all of them had improved and three were no longer in pain, although sensory alterations persisted in all cases. CONCLUSIONS: Post-traumatic supraorbital neuralgia is a frequent condition, although it is probably underdiagnosed. It has its own characteristic clinical and developmental features that distinguish it from idiopathic supraorbital neuralgia. Progress is usually good and it responds favourably to symptomatic treatment, if needed.


Subject(s)
Cranial Nerve Diseases/etiology , Facial Injuries/complications , Neuralgia/etiology , Ophthalmic Nerve/injuries , Accidental Falls , Adult , Aged , Amines/therapeutic use , Amitriptyline/therapeutic use , Axotomy , Cranial Nerve Diseases/drug therapy , Cranial Nerve Diseases/surgery , Cyclohexanecarboxylic Acids/therapeutic use , Diagnosis, Differential , Female , Gabapentin , Humans , Male , Middle Aged , Nerve Block , Neuralgia/diagnosis , Neuralgia/drug therapy , Neuralgia/surgery , Ophthalmic Nerve/physiopathology , Ophthalmic Nerve/surgery , Prognosis , Sensation Disorders/etiology , gamma-Aminobutyric Acid/therapeutic use
16.
Curr Eye Res ; 31(6): 511-7, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16769610

ABSTRACT

PURPOSE: To learn if peripheral nerve pathways are necessary for corneal expansion and anterior segment growth under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing. METHODS: Recently hatched White Leghorn chicks under anesthesia received unilateral ciliary ganglionectomy (CGx), cranial cervical ganglionectomy (Sx), or section of the ophthalmic nerve (TGx), along with sham-operated and/or never-operated control cohorts. Chicks were reared postoperatively under either a 12-hr light:dark cycle or under constant light. After 2 weeks and with the chicks under anesthesia, corneal radii of curvature and diameters were obtained with a photokeratoscope, refractometry and A-scan ultrasonography were performed, and the axial and equatorial dimensions of enucleated eyes were measured with digital calipers. Corneal areas were calculated from corneal curvatures and diameters. RESULTS: Despite the rich peripheral innervation to the eye, the selective denervations performed here exerted remarkably limited effects on corneal expansion and anterior segment development in chicks reared under either lighting condition. Ophthalmic nerve section did reverse in large part the inhibition of equatorial expansion of the vitreous chamber occurring under constant light rearing. CONCLUSIONS: The ciliary, sympathetic, or ophthalmic peripheral nerve pathways to the eye are not required either for corneal expansion and anterior segment development under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing. The ocular sensory innervation may be a means for regulating vitreous cavity shape.


Subject(s)
Anterior Eye Segment/growth & development , Anterior Eye Segment/innervation , Peripheral Nerves/physiology , Animals , Animals, Newborn , Chickens , Ciliary Body/innervation , Cornea/anatomy & histology , Cornea/diagnostic imaging , Cornea/innervation , Dark Adaptation , Ganglionectomy , Neck Muscles/innervation , Neural Pathways/physiology , Ophthalmic Nerve/physiology , Ophthalmic Nerve/surgery , Trigeminal Ganglion/physiology , Trigeminal Ganglion/surgery , Ultrasonography
17.
Invest Ophthalmol Vis Sci ; 46(9): 3121-7, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16123410

ABSTRACT

PURPOSE: To investigate the effect of nerve growth factor (NGF) in combination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a rabbit model after PRK and correlate the findings with functional tear test. METHODS: Unilateral PRK was performed on 21 New Zealand albino rabbits. Three groups, each consisting of six rabbits, were randomized to receive twice-weekly treatments with DHA, NGF, or NGF plus DHA delivered by collagen shield. A fourth group, the control, received treatment with albumin. Rabbits were observed for 8 weeks, and tear secretion tests were conducted every 15 days. The eyes were prepared for immunostaining. Monoclonal antibodies for class II beta-tubulin, calcitonin gene-related peptide (CGRP), substance P (SP), and Ki-67 were used. Cell nuclei were stained with 4',6'-diamino-2-phenylindole (DAPI). Positive staining areas in relation to total area were calculated with image-analysis software. RESULTS: There were no significant differences in the tear-secretion test results among the four groups. However, none of the eyes treated with NGF plus DHA showed rose bengal staining 30 days after PRK, compared with 50% in the control group and 33% in the DHA-treated group. A higher percentage of Ki-67-positive cells, a marker of cell proliferation, was observed in the DHA plus NGF-and NGF-treated groups compared with DHA alone or the control. Eight weeks after PRK, tubulin-positive and CGRP-positive epithelial and subbasal nerve bundle areas were significantly higher in the DHA plus NGF group than in the control and NGF or DHA alone. No differences were noted in the SP-positive nerve bundles between the different treatments and the control treatment. CONCLUSIONS: NGF plus DHA treatment after PRK in rabbits is associated with increased corneal nerve surface area, increased epithelial proliferation, and decreased rose bengal staining compared with NGF, DHA, or vehicle control alone. The combination of NGF plus DHA yields faster nerve recovery after PRK and may have therapeutic usefulness in the treatment of post-PRK dry eye and other neurotrophic keratopathies.


Subject(s)
Cornea/innervation , Docosahexaenoic Acids/administration & dosage , Nerve Growth Factor/administration & dosage , Nerve Regeneration/drug effects , Ophthalmic Nerve/physiology , Photorefractive Keratectomy , Administration, Topical , Animals , Calcitonin Gene-Related Peptide/metabolism , Cornea/metabolism , Cornea/surgery , Drug Combinations , Drug Delivery Systems , Fluorescent Dyes , Gas Chromatography-Mass Spectrometry , Ki-67 Antigen/metabolism , Lasers, Excimer , Ophthalmic Nerve/metabolism , Ophthalmic Nerve/surgery , Rabbits , Rose Bengal , Substance P/metabolism , Tears/metabolism , Tubulin/metabolism
18.
Cornea ; 24(6): 654-60, 2005 Aug.
Article in English | MEDLINE | ID: mdl-16015082

ABSTRACT

PURPOSE: This study was designed to compare and evaluate the efficacy of amniotic membrane transplantation with the conventional management (tarsorrhaphy and bandage contact lens) in eyes with refractory neurotrophic corneal ulcers. METHODS: Thirty eyes of 30 patients (14 females and 16 males) with neurotrophic corneal ulcers refractory to medical management were included and divided randomly into group 1 (n = 15), who received conventional management with a tarsorrhaphy (n = 11) or bandage contact lens (n = 4), and group 2 (n = 15), who underwent Amniotic Membrane Transplantation. The outcome parameters evaluated were epithelialization time, duration of healing of corneal ulcers, and improvement in best corrected visual acuity. RESULTS: The mean age in our study was 37 +/- 14.71 years. At the end of 3 months follow-up, 10 of 15 patients (66.67%) in group 1 showed complete epithelialization and subsequent healing and 11 of 15 patients (73.33%) in group 2 showed complete epithelialization and healing (P > 0.05). The median time for complete epithelialization was 21 days in both groups. Both groups showed an improvement in the best-corrected visual acuity. CONCLUSIONS: Both amniotic membrane transplantation and conventional management (tarsorrhaphy or bandage contact lens) are effective treatment modalities for refractory neurotrophic corneal ulcers.


Subject(s)
Amnion/transplantation , Biological Dressings , Cornea/innervation , Corneal Ulcer/surgery , Cranial Nerve Diseases/surgery , Ophthalmic Nerve/surgery , Adolescent , Adult , Aged , Child , Contact Lenses , Epithelium, Corneal/cytology , Epithelium, Corneal/physiology , Eyelids/surgery , Female , Humans , Male , Middle Aged , Prospective Studies , Visual Acuity , Wound Healing
19.
Plast Reconstr Surg ; 135(2): 397e-400e, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25626824

ABSTRACT

Corneal anesthesia is a debilitating condition which can ultimately lead to blindness from repetitive corneal injury and scarring. We have developed a minimally invasive technique for corneal re-innervation that we have used with excellent results in ten eyes. This article and accompanying video describes the relevant anatomy and demonstrates the technique in detail.


Subject(s)
Cornea/innervation , Corneal Diseases/surgery , Hypesthesia/surgery , Nerve Transfer/methods , Ophthalmic Nerve/surgery , Sural Nerve/transplantation , Adult , Child , Corneal Diseases/congenital , Corneal Diseases/etiology , Corneal Diseases/physiopathology , Corneal Injuries/complications , Eye Pain/etiology , Humans , Hypesthesia/congenital , Hypesthesia/etiology , Hypesthesia/physiopathology , Minimally Invasive Surgical Procedures , Nerve Regeneration , Ophthalmic Nerve/physiology , Pain, Postoperative/etiology , Transplantation, Heterotopic
20.
Ophthalmology ; 111(12): 2158-63, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15582068

ABSTRACT

OBJECTIVE: To compare the efficacy and efficiency of a new small anterior incision, minimal dissection ptosis procedure with that of a traditional anterior aponeurotic approach for the correction of aponeurotic ptosis. DESIGN: Retrospective, comparative, interventional case series. PARTICIPANTS: Seventy-two patients with aponeurotic ptosis who had undergone ptosis correction surgery by 1 surgeon: 36 patients (49 ptotic eyelids) who had ptosis correction by a small-incision, minimal dissection procedure and 36 patients (49 ptotic eyelids) who had ptosis correction by a traditional aponeurotic approach. METHODS: Charts and available photographs were reviewed for each patient. MAIN OUTCOME MEASURES: Postoperative upper eyelid height relative to the center of the pupil and relative to the opposite upper eyelid and the postoperative eyelid contour. RESULTS: Successful correction of the eyelid height and the rate of recommended reoperation were not significantly different for the 49 lids corrected in each arm of the study. The incidence of attaining good eyelid contour was significantly better in the small incision group, in which 41 of 42 lids (97.6%) evaluated by photographs had good contour compared with 29 of 37 lids (78.4%) in the traditional group. Operating time per lid was significantly less for the small-incision, minimal dissection group, 25.3+/-13.0 minutes (range, 13-68 minutes) compared with 55.4+/-16.6 minutes (range, 35-119) for the traditional group. CONCLUSIONS: The small-incision, minimal dissection technique for ptosis correction is equally effective in correcting eyelid height, superior in producing desirable eyelid contour, and much quicker to perform than the traditional aponeurotic approach.


Subject(s)
Blepharoplasty/methods , Blepharoptosis/surgery , Eyelids/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Eyelids/innervation , Female , Follow-Up Studies , Humans , Male , Middle Aged , Minimally Invasive Surgical Procedures , Oculomotor Muscles/surgery , Ophthalmic Nerve/surgery , Retrospective Studies , Treatment Outcome
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