SEnDAE: A resource for expanding research into social and environmental determinants of health.

BACKGROUND AND OBJECTIVE: Social and Environmental Determinants of Health (SEDoH) are of increasing interest to researchers in personal and public health. Collecting SEDoH and associating them with patient medical record can be challenging, especially for environmental variables. We announce here the release of SEnDAE, the Social and Environmental Determinants Address Enhancement toolkit, and open-source resource for ingesting a range of environmental variables and measurements from a variety of sources and associated them with arbitrary addresses. METHODS: SEnDAE includes optional components for geocoding addresses, in case an organization does not have independent capabilities in that area, and recipes for extending the OMOP CDM and the ontology of an i2b2 instance to display and compute over the SEnDAE variables within i2b2. RESULTS: On a set of 5000 synthetic addresses, SEnDAE was able to geocode 83%. SEnDAE geocodes addresses to the same Census tract as ESRI 98.1% of the time. CONCLUSION: Development of SEnDAE is ongoing, but we hope that teams will find it useful to increase their usage of environmental variables and increase the field's general understanding of these important determinants of health.

Development of a COVID-19 Application Ontology for the ACT Network.

Clinical data networks that leverage large volumes of data in electronic health records (EHRs) are significant resources for research on coronavirus disease 2019 (COVID-19). Data harmonization is a key challenge in seamless use of multisite EHRs for COVID-19 research. We developed a COVID-19 application ontology in the national Accrual to Clinical Trials (ACT) network that enables harmonization of data elements that that are critical to COVID-19 research. The ontology contains over 50,000 concepts in the domains of diagnosis, procedures, medications, and laboratory tests. In particular, it has computational phenotypes to characterize the course of illness and outcomes, derived terms, and harmonized value sets for SARS-CoV-2 laboratory tests. The ontology was deployed and validated on the ACT COVID-19 network that consists of nine academic health centers with data on 14.5M patients. This ontology, which is freely available to the entire research community on GitHub at https://github.com/shyamvis/ACT-COVID-Ontology, will be useful for harmonizing EHRs for COVID-19 research beyond the ACT network.

Development of a Coronavirus Disease 2019 (COVID-19) Application Ontology for the Accrual to Clinical Trials (ACT) network.

Clinical data networks that leverage large volumes of data in electronic health records (EHRs) are significant resources for research on coronavirus disease 2019 (COVID-19). Data harmonization is a key challenge in seamless use of multisite EHRs for COVID-19 research. We developed a COVID-19 application ontology in the national Accrual to Clinical Trials (ACT) network that enables harmonization of data elements that are critical to COVID-19 research. The ontology contains over 50 000 concepts in the domains of diagnosis, procedures, medications, and laboratory tests. In particular, it has computational phenotypes to characterize the course of illness and outcomes, derived terms, and harmonized value sets for severe acute respiratory syndrome coronavirus 2 laboratory tests. The ontology was deployed and validated on the ACT COVID-19 network that consists of 9 academic health centers with data on 14.5M patients. This ontology, which is freely available to the entire research community on GitHub at https://github.com/shyamvis/ACT-COVID-Ontology, will be useful for harmonizing EHRs for COVID-19 research beyond the ACT network.