FGF12 copy number variant associated with epileptic encephalopathy.

FGF12 related epilepsy presents with variable phenotypes. We report another patient with a duplication involving the FGF12 gene who presented similar to other published cases having normal early development and responded to phenytoin.

Therapeutic Targeting of Hypoxia-Inducible Factors in Cancer.

In the realm of cancer therapeutics, targeting the hypoxia-inducible factor (HIF) pathway has emerged as a promising strategy. This study delves into the intricate web of HIF-associated mechanisms, exploring avenues for future anticancer therapies. Framing the investigation within the broader context of cancer progression and hypoxia response, this article aims to decipher the pivotal role played by HIF in regulating genes influencing angiogenesis, cell proliferation, and glucose metabolism. Employing diverse approaches such as HIF inhibitors, anti-angiogenic therapies, and hypoxia-activated prodrugs, the research methodologically intervenes at different nodes of the HIF pathway. Findings showcase the efficacy of agents like EZN-2968, Minnelide, and Acriflavine in modulating HIF-1α protein synthesis and destabilizing HIF-1, providing preliminary proof of HIF-1α mRNA modulation and antitumor activity. However, challenges, including toxicity, necessitate continued exploration and development, as exemplified by ongoing clinical trials. This article concludes by emphasizing the potential of targeted HIF therapies in disrupting cancer-related signaling pathways.

Inherited CSNK2A1 variants in families with Okur-Chung neurodevelopmental syndrome.

Pedigree showing the autosomal dominant inheritance pattern of CSNK21 variants in families presenting with OCNDS. (A) Maternal inheritance to two daughters in Family 1, (B) Paternal inheritance to a daughter in Family 2, and (C) Maternal inheritance to two sons in Family 3.

Should I write about mental health on my med school app? Examining medical school admissions committee members' biases regarding mental health conditions.

Mental health conditions can impact college students' academic achievements and experiences. As such, students may choose to disclose mental illnesses on medical school applications. Yet, no recent studies have investigated to what extent disclosure of a mental health condition may impact whether an applicant is accepted to medical school. We conducted an audit study to address this gap and surveyed 99 potential medical school admissions committee members from over 40 M.D.-granting schools in the United States. Participants rated a fictitious portion of a single medical school application on acceptability, competence, and likeability. They were randomly assigned to a condition: an application that explained a low semester grade-point average due to 1) a mental health condition, 2) a physical health condition, or 3) offered no explanation. After rating their respective application, all committee members were asked about when revealing a mental health condition would be beneficial and when it would be detrimental. Using ANOVAs, multinomial regression, and open coding, we found that medical school admissions committee members do not rate applications lower when a mental health condition is revealed. Committee members highlighted that revealing a mental health condition to demonstrate resiliency could be beneficial, but if the reference is vague or the condition is not being managed, it could be detrimental to a student's application. This work indicates that medical school admissions committee members do not exhibit a bias against mental health conditions and provides recommendations on how to discuss mental illness on medical school applications.

Evaluation of Different Local Drug Delivery Systems in the Management of Chronic Periodontitis: A Comparative Study.

AIM: The present study aimed to assess the use of various local drug delivery systems in the management of chronic periodontitis. MATERIALS AND METHODS: A total of 60 patients aged around 30-55 years were included. The subjects who were enrolled under took a phase I therapy that included scaling and root planing (SRP). Patients who satisfied the conditions for selection to enter the trial were assigned randomly to three groups, with each group consisting of 20 participants as follows: group I: controlled-release drugs-chlorhexidine gel, group II: metronidazole gel, group III: tetracycline fibers. The plaque index (PI), gingival index (GI), and periodontal pocket depth (PPD) were recorded after 1st week as the baseline data and were recorded again after 15 days and 30 days post-baseline. RESULTS: The mean GI scores were 1.32 ± 0.10, 0.88 ± 0.16, and 0.76 ± 0.12, at baseline, 15 days, and 30 days, respectively, in group I. In group II, the mean GI score reduced to 1.09 ± 0.83 at 30 days from 1.48 ± 0.27 at baseline. Likewise, in group III the mean GI score reduced to 0.90 ± 0.62 at 30 days from 1.38 ± 0.06 at baseline. All the groups demonstrated a statistically significant difference at various intervals. The mean PI score decreased to 0.90 ± 0.78 at 15 days from 1.46 ± 0.22 at baseline in group III. A statistically significant difference at different intervals was seen in group III only. In all groups, the intergroup comparison of PPD was found to be statistically significant. CONCLUSION: This study demonstrated that although thorough SRP is an effective treatment method for elimination of chronic periodontal pockets, improved results can be obtained by adjunctive use of locally administered chlorhexidine gel, metronidazole gel, and tetracycline fibers. CLINICAL SIGNIFICANCE: The use of the adjunctive local drug delivery system along with mechanical cleansing in the treatment of periodontal pockets in chronic periodontitis is therapeutically beneficial.

The imaginative mind.

The astounding capacity for the human imagination to be engaged across a wide range of contexts is limitless and fundamental to our day-to-day experiences. Although processes of imagination are central to human psychological function, they rarely occupy center stage in academic discourse or empirical study within psychological and neuroscientific realms. The aim of this paper is to tackle this imbalance by drawing together the multitudinous facets of imagination within a common framework. The processes fall into one of five categories depending on whether they are characterized as involving perceptual/motor related mental imagery, intentionality or recollective processing, novel combinatorial or generative processing, exceptional phenomenology in the aesthetic response, or altered psychological states which range from commonplace to dysfunctional. These proposed categories are defined on the basis of theoretical ideas from philosophy as well as empirical evidence from neuroscience. By synthesizing the findings across these domains of imagination, this novel five-part or quinquepartite classification of the human imagination aids in systematizing, and thereby abets, our understanding of the workings and neural foundations of the human imagination. It would serve as a blueprint to direct further advances in the field of imagination while also promoting crosstalk with reference to stimulus-oriented facets of information processing. A biologically and ecologically valid psychology is one that seeks to explain fundamental aspects of human nature. Given the ubiquitous nature of the imaginative operations in our daily lives, there can be little doubt that these quintessential aspects of the mind should be central to the discussion. Hum Brain Mapp 37:4197-4211, 2016. © 2016 Wiley Periodicals, Inc.

Evaluating the effects of episodic and semantic memory induction procedures on divergent thinking in younger and older adults.

Evidence suggesting that episodic specificity induction improves divergent thinking performance in younger and older adults has been taken as indicative of the role of declarative memory processes in creativity. A series of studies were carried out to verify the specificity of such findings by investigating the effects of several novel episodic and semantic memory induction procedures on a widely employed measure of divergent creative thinking (the Alternate Uses Task), in comparison to a control induction and a no-induction baseline in both younger and older adults. There was no clear evidence for a specific role played by the induction of episodic or semantic memory processes in facilitating creative thinking across the three experiments, and the effects of the induction procedures (episodic, semantic and control) on divergent thinking were not comparable across age groups. On the other hand, higher levels of creativity were generally associated with older adults (60-80 years). In Experiments 2 and 3, older adults generated a greater number of responses (fluency), more unique responses (average originality, peak originality, creativity ratings) and more varied responses (flexibility) than younger adults (18-30 years). The findings are discussed in relation to the specificity of declarative memory operations and their impact on creative thinking, especially within the context of healthy ageing.

Can clouds dance? Part 2: an ERP investigation of passive conceptual expansion.

Conceptual expansion, one of the core operations in creative cognition, was investigated in the present ERP study. An experimental paradigm using novel metaphoric, nonsensical and literal phrases was employed where individual differences in conceptual knowledge organization were accounted for by using participants' responses to categorize the stimuli to each condition. The categorization was determined by their judgment of the stimuli on the two defining criteria of creativity: unusualness and appropriateness. Phrases judged as unusual and appropriate were of special interest as they are novel and unfamiliar phrases thought to passively induce conceptual expansion. The results showed a graded N400 modulation for phrases judged to be unusual and inappropriate (nonsense) or unusual and appropriate (conceptual expansion, novel metaphorical) relative to usual and appropriate (literal) phrases. The N400 is interpreted as indexing greater effort to retrieve semantic information and integrate the novel concepts presented through the phrases. Analyses of the later time-window showed an ongoing negativity that was graded in the same manner as the N400. The findings attest to the usefulness of investigating creative cognition using event-related electrophysiology.

Can clouds dance? Neural correlates of passive conceptual expansion using a metaphor processing task: Implications for creative cognition.

Creativity has emerged in the focus of neurocognitive research in the past decade. However, a heterogeneous pattern of brain areas has been implicated as underpinning the neural correlates of creativity. One explanation for these divergent findings lies in the fact that creativity is not usually investigated in terms of its many underlying cognitive processes. The present fMRI study focuses on the neural correlates of conceptual expansion, a central component of all creative processes. The study aims to avoid pitfalls of previous fMRI studies on creativity by employing a novel paradigm. Participants were presented with phrases and made judgments regarding both the unusualness and the appropriateness of the stimuli, corresponding to the two defining criteria of creativity. According to their respective evaluation, three subject-determined experimental conditions were obtained. Phrases judged as both unusual and appropriate were classified as indicating conceptual expansion in participants. The findings reveal the involvement of frontal and temporal regions when engaging in passive conceptual expansion as opposed to the information processing of mere unusualness (novelty) or appropriateness (relevance). Taking this new experimental approach to uncover specific processes involved in creative cognition revealed that frontal and temporal regions known to be involved in semantic cognition and relational reasoning play a role in passive conceptual expansion. Adopting a different vantage point on the investigation of creativity would allow for critical advances in future research on this topic.

The role of personality traits and leisure activities in predicting wellbeing in young people.

BACKGROUND: The relationship between wellbeing and personality has been studied extensively, but few studies have examined these in the period of adolescence and emerging adulthood. Moreover, the influence of contextual factors such as engagement in leisure activities are rarely considered. METHODS: The present study employs a combination of frequentist and Bayesian analyses to evaluate the concurrent impact of personality traits and leisure activities on five conceptions of wellbeing (life satisfaction; positive affect; negative affect; mental health; flourishing) in three cohorts of young people (aged 14-15; 16-17; 18-20 years). RESULTS: Personality traits were the only significant predictors of life satisfaction and negative affect, but leisure activities in the form of socialising or physical activity, in addition to personality traits, predicted positive affect, mental health and flourishing. Neuroticism was the largest predictor of wellbeing overall, whereas conscientiousness was the most consistent. Lower levels of wellbeing were also associated with higher levels of creative potential. CONCLUSIONS: The study not only confirms the importance of personality traits as predictors of wellbeing in adolescents and young adults, but also indicates the necessity to consider the impact of leisure activities in different conceptions of wellbeing. The negative relationship between creative potential and wellbeing is in line with the literature which shows a link between mental illness, particularly at subclinical levels, and creativity.

Instructor Perceptions of Student Incivility in the Online Undergraduate Science Classroom.

Student incivility, defined as a student behavior perceived to be disrespectful or disruptive to the overall learning environment in a course, can negatively affect the science learning environment and instructors. The transition to online science courses during the COVID-19 pandemic created a unique environment for student incivility to take place in undergraduate courses. There are few studies that examine student incivility in online synchronous courses, and we know of no studies that have investigated student incivility during the COVID-19 pandemic. In this study, we surveyed 283 instructors across U.S. institutions who taught undergraduate science courses with synchronous online components. We probed their experiences with student incivility during the fall 2020 term. Over half of instructors surveyed reported experiencing student incivility, with women being more likely than men to report student incivility. Compared with white instructors, people of color were more likely to perceive an increase in student incivility in fall 2020 relative to previous in-person terms. This work indicates that student incivility is perceived in the online synchronous learning environment and that the negative impacts of perceived student incivility during COVID-19 online instruction were not distributed equally among instructors, disproportionately burdening women and people of color.

How collaborative mental health care for competitive and high-performance athletes is implemented: A novel interdisciplinary case study.

Introduction: Collaborative care is considered a best practice in mental health care delivery and has recently been applied in high-performance sport to address athletes' mental health needs. However, how the collaborative process unfolds in practice in the sport setting has not yet been well documented. The purpose of this illustrative case study was to investigate a novel interdisciplinary approach used within the Canadian Centre for Mental Health and Sport (CCMHS) to provide mental health care to clients. Focusing on 'how' the approach was implemented, the aim of the study was to provide insight into the collaboration that occurred between mental performance and mental health practitioners to provide care to a high-performance athlete over an 11-month period, as well as factors facilitating and impeding the team's collaboration. The case involved three practitioners and a 16-year-old female athlete experiencing chronic pain, low mood, and elevated anxiety. Methods: In the first phase of the data collection process, each practitioner engaged in guided reflective journaling to describe the case and reflect on their practice and outcomes. During the second phase, practitioners co-created a case timeline to describe the collaborative process using clinical documents. Lastly, practitioners participated in collaborative reflection to collectively reflect more broadly on collaboration practice occurring within the CCMHS and Canadian sport system. Results: The data depict a complex care process in which the necessity and intensity of collaboration was primarily driven by the client's symptoms and needs. A content analysis showed that collaboration was facilitated by the CCMHS' secure online platform and tools, as well as individual practitioner and team characteristics. Collaboration was, however, hindered by logistical challenges, overlapping scopes of practice, and client characteristics. Discussion: Overall, there were more perceived benefits than drawbacks to providing collaborative care. While flexibility was required during the process, deliberate and systematic planning helped to ensure success. Factors such as interdependence of collaborative practice, complementarity of practice within care teams, compensation for collaboration, in-person versus virtual delivery, and intricacies of care coordination should be further examined in the future to optimize collaborative mental health care in sport.

Conceptual expansion via novel metaphor processing: An ERP replication and extension study examining individual differences in creativity.

The aims of the present ERP study were twofold. First, to determine whether a previous study on creative cognition could be replicated, and second, to extend these findings by examining individual differences in creativity. Conceptual expansion, a capacity that is central to creativity, was induced via the processing of novel metaphors. Brain activity patterns in relation to these were compared to the processing of literal and nonsense phrases. The previous findings were replicated in that the N400, known for its sensitivity to semantic anomalies, indexed the originality of the phrases, while a post-N400 late component (LC), which is linked to semantic integration processes, indexed the appropriateness of the phrases. Moreover, only the LC was significantly sensitive to individual differences in creativity in the processing of these phrases. Differences at the level of semantic integration processes as well as the structure of knowledge organization are thereby implicated in individual differences in creativity.

A review on sources and health impacts of bisphenol A.

Bisphenol-A (BPA) is a synthetic chemical used in the manufacturing of polycarbonates and epoxy resins. This paper is a review of studies reporting the occurrences and concentrations of BPA in the environment and associated impact on human health. Studies have found that at high temperature conditions such as open burning of dumped waste in developing nations can relocate BPA from plastic waste into the environment. BPA is a proven endocrine disruptor capable of mimicking or blocking the receptors and altering hormone concentrations and its metabolism. Even though it is consumed in a low dose, it can stimulate cellular responses and affect body functions. Biomonitoring studies show that human and animal exposure to BPA is rapid and continuous. In-depth studies are needed to understand the fate of these compounds particularly in the developing nations and the associated adverse health impacts of BPA due to prolonged exposure.

Prevalence of Dental Caries and Treatment Needs in Tibetan Monks and Nuns in Karnataka.

AIM: The aim of this study was to assess the prevalence of dental caries and treatment needs among Tibetan monks and nuns in Bylakuppe. MATERIALS AND METHODS: In this cross-sectional study, stratified random sampling was used to obtain desired sample for the study. The clinical examination was carried out to obtain data regarding dental caries status and treatment needs using World Health Organization (WHO) Oral Health Assessment Pro forma 1997. Statistical analysis was carried out using Statistical Package for the Social Sciences (SPSS) software program, version 20.0. The data were statistically analyzed by using descriptive statistics and chi-square test. RESULTS: The study population consisted of 345 Tibetan monks (men) and 35 Tibetan nuns (women). Prevalence of dental caries was 88.68% with mean decayed, missing, and filled teeth (DMFT) value of 6.06 ± 5.37. Assessment of dental treatment needs showed 82.3% of participants needed one surface filling, 11.9% of participants needed pulp care and restoration, and 9.3% of participants required extraction of teeth. CONCLUSION: The study population is characterized by high prevalence of dental caries and lack of awareness about treatment needs.

Thinking about the future versus the past in personal and non-personal contexts.

The ability to ponder the future is a hallmark of human imagination. Neuroimaging research so far has focused on episodic prospection, or thinking about hypothetical future personal events. What has received no attention is semantic prospection or contemplating hypothetical future world events. Using functional magnetic resonance imaging (fMRI), we show a number of functional dissociations in the brain when comparing future and past thinking across personal and non-personal conceptual domains. In the prefrontal cortex, the processes of information integration and self-referential thinking in the anterior medial prefrontal cortex were differentiated from those pertaining to generative construction along the dorsal medial prefrontal cortex and adjoining regions in the superior frontal gyrus. Dorsal parts of the lateral inferior parietal lobe showed lateralization effects as a function of the divergent or convergent nature of the retrieval process corresponding to whether the accessed information referred to hypothetical or real events. While ventral parts of the bilateral inferior parietal lobe were preferentially engaged during both personal past and personal future thinking, dissociations between the areas involved in personal past versus personal future thinking were found along the medial parietal wall. All in all, these findings provide novel and critical insights into the complex interactions between different processes involved in prospective and retrospective thought as modulated by the type of processed content.

Minds, persons, and space: an fMRI investigation into the relational complexity of higher-order intentionality.

Mental state reasoning or theory-of-mind has been the subject of a rich body of imaging research. Although such investigations routinely tap a common set of regions, the precise function of each area remains a contentious matter. With the help of functional magnetic resonance imaging (fMRI), we sought to determine which areas are involved when processing mental state or intentional metarepresentations by focusing on the relational aspect of such representations. Using non-intentional relational representations such as spatial relations between persons and between objects as a contrast, the results ascertained the involvement of the precuneus, the temporal poles, and the medial prefrontal cortex in the processing of intentional representations. In contrast, the anterior superior temporal sulcus and the left temporo-parietal junction were implicated when processing representations that refer to the presence of persons in relational contexts in general. The right temporo-parietal junction, however, was specifically activated for persons entering spatial relations. The level of representational complexity, a previously unexplored factor, was also found to modulate the neural response in some brain regions, such as the medial prefrontal cortex and the right temporo-parietal junction. These findings highlight the need to take into account the critical roles played by an extensive network of neural regions during mental state reasoning.

Creative conceptual expansion: A combined fMRI replication and extension study to examine individual differences in creativity.

The aims of this fMRI study were two-fold. The first objective of the study was to verify whether the findings associated with a previous fMRI study could be replicated in which a novel event-related experimental design was developed which rendered it possible to investigate the brain basis of creative conceptual expansion. The ability to widen the boundaries of conceptual structures is integral to creative idea generation, which makes conceptual expansion a core component of creative cognition. Creative conceptual expansion led to the engagement of brain regions that are known to be involved in the access, storage and relational integration of conceptual knowledge in the original study. These included the anterior inferior frontal gyrus, the temporal poles and the lateral frontal pole. These findings in relation to the brain basis of creative conceptual expansion were replicated in the current study. The second objective of this study was to evaluate the brain basis of individual differences in creative conceptual expansion. The high creative group relative to the low creative group was shown to exhibit greater activity in regions of the semantic cognition network as well as the salience network during creative conceptual expansion. The findings are discussed from the point of view of classical hypotheses about information processing biases that explain individual differences in creativity including flat associative hierarchies, defocused attention and cognitive disinhibition.

Creative thinking in adolescents with attention deficit hyperactivity disorder (ADHD).

A widened attentional focus, that is typically associated with ADHD, has been postulated to be accompanied by enhanced creative ability. However, creativity has been only limitedly examined in ADHD. Performance across several creativity measures were investigated in three groups: adolescents with ADHD, those with conduct disorder, and a healthy control sample. The ADHD group exhibited selective cognitive advantages and disadvantages by demonstrating an enhanced ability in overcoming the constraining influence of examples, but a reduced capacity to generate a functional invention during an imagery task. These findings are interpreted with reference to inhibitory control mechanisms and the contextual modulation of creative cognition.