1.
Chemistry
; 22(19): 6491-5, 2016 May 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26956002
RESUMEN
A chemical exchange saturation transfer (CEST) MRI contrast agent has been developed that detects sulfatase enzyme activity. The agent produces a CEST signal at δ=5.0â ppm before enzyme activity, and a second CEST signal appears at δ=9.0â ppm after the enzyme cleaves a sulfate group from the agent. The comparison of the two signals improved detection of sulfatase activity.