RESUMEN
BACKGROUND: Cutaneous, superficial and or suprafascial leiomyoma are divided into three variants: piloleiomyomas (PL), angioleiomyomas (AL) and genital leiomyomas (GL) that include the vulvar, scrotal and areolar forms. This study set out to establish the clinical and histological characteristics and incidence of each variant, and any likely associations with internal neoplasms. METHODS: A review was carried out of 255 cases of cutaneous leiomyomas diagnosed between 1982 and 2018 at the Pathology departments of three hospitals (Navarra and Alicante). Demographic, clinical, histological and immunohistochemical variables were described and compared. RESULTS: The incidence of PL in Navarra was 4.3 cases per million inhabitants a year, with another 20 cases of AL and 1.4 cases of GL. Cutaneous forms make up approximately 3.5% of the total leiomyomas. The population with PL suffered more frequently from breast cancer (OR?=?4.8; CI 95%: 1.3-17.4; p?=?0.006). Nipple leiomyomas are small, accompanied by localised pain, and are predominantly fascicular or solid, with very infrequent effect on the subcutaneous cellular tissue and scarce atypia. This makes for a contrast with the other GLs, which are medium sized and infrequently painful, predominantly nodular, and frequent effect on the subcutaneous tissue and atypia. CONCLUSIONS: The information provided here about the clinical and histological characteristics of the different varieties of leiomyomas indicate that there is a need to reconsider the classification of nipple leiomyomas outside the group of GLs. An association between PL and breast carcinoma was detected, which needs to be confirmed in future studies so as to determine if this leiomyoma is a risk marker for breast cancer.
Asunto(s)
Leiomioma , Neoplasias Cutáneas , Humanos , Leiomioma/epidemiología , Neoplasias Cutáneas/epidemiologíaRESUMEN
BACKGROUND: Lip eczema is an infrequent problem in Contact Dermatitis Units (CDU). Very few series have been published to date that show the profiles of such patients and the causes of their eczemas, and none are Spanish. The goal of this study was to analyze the epidemiological profile of the patients who attend a CDU in our setting, the main diagnoses and the relevant allergens. METHODS: A retrospective review was made of the patients referred to the CDU in the 2005-2014 period. Patch tests were carried out with the extended standard series of the Spanish Research Group on Allergic Contact Dermatitis (Grupo Español de Investigación en Dermatitis Alérgica de contacto - GEIDAC), our own products and other complementary sets. RESULTS: The most frequent diagnoses in the 78 patients studied were allergic contact dermatitis and atopic dermatitis. The most frequent relevant allergens were cosmetics and topical medications. CONCLUSIONS: It is essential to study the patients with lip eczema with patch tests to be able to correctly determine their etiology and accordingly to carry out the most suitable treatment.
Asunto(s)
Dermatitis Atópica/diagnóstico , Eccema/diagnóstico , Labio , Enfermedades de la Boca/diagnóstico , Centros de Atención Terciaria , Alérgenos , Humanos , Pruebas del Parche/efectos adversos , Estudios RetrospectivosRESUMEN
BACKGROUND: Tea tree oil is an essential oil, whose use is increasing in our setting, due both to its supposed medicinal effects and to its aromatic properties. We describe our experience with allergic contact dermatitis following the application of this oil. MATERIAL AND METHODS: Five patients in the last 5 years (0.4% of all the patients studied in specialized consultation) reacted to a 5% concentration of tea tree oil in Vaseline. RESULTS: All the patients presented strong reactions, and in all cases these were considered relevant. Three of them also reacted to oxidized d-limonene, one of the components of tea tree oil, which is present in our standard series. CONCLUSIONS: Different cases have been described in the literature on allergic contact dermatitis due to tea tree oil, but until recently it was infrequent in our setting. With the increased popularity of alternative and natural therapies we have witnessed several cases of sensitization to this essential oil, which had been used to treat several supposedly "infectious" skin diseases, but which were very probably different forms of dermatitis.