Cu/Cu2O/C nanoparticles and MXene based composite for non-enzymatic glucose sensors.

Copper/Cuprous oxide/Carbon nanoparticles decorated MXene composite was prepared and subsequently examined for its potential application as a non-enzymatic glucose sensor. To carry out this, initially the Cu MOF/MXene composite was synthesised by the hydrothermal method and was annealed in an unreacted environment at different time intervals. During this process, petal like Cu MOF on MXene loses the organic ligands to form a Cu/Cu2O/C based nanoparticles on MXene. Further, an electrode was fabricated with the developed material for understanding the sensing performance by cyclic voltammetry and chronoamperometry in 0.1 M NaOH solution. Results reveal that the highest weight percentage of copper oxide in the composite (15 min of annealed material) shows a higher electro catalytic activity for sensing glucose molecules due to more active sites with good electron transfer ability in the composite. The formed composite exhibits a wide linear range of 0.001-26.5 mM, with a sensitivity of 762.53µAmM-1cm-2(0.001-10.1 mM), and 397.18µAmM-1cm-2(11.2-26.9 mM) and the limit of detection was 0.103µM. In addition to this, the prepared electrode shows a good reusability, repeatability, selectivity with other interferences, stability (93.65% after 30 days of storage), and feasibility of measuring glucose in real samples. This finding reveals that the metal oxide derived from MOF based nanoparticle on the MXene surface will promote the use of non-enzymatic glucose sensors.

Experimental and computational DFT, drift-diffusion studies of cobalt-based hybrid perovskite crystals as absorbers in perovskite solar cells.

The optimised designs of dimethyl ammonium cobalt formate-based perovskite crystals [(CH3)2NH2]Co(HCOO)3 were experimentally synthesized and computationally utilized as absorbers for perovskite solar cells (PSCs). Crystals were grown using solvothermal synthesis. Additive materials (Fe, Ni) are responsible for the growth and suppression of crystals in the micrometre range. Temperature and pressure were altered to obtain optimum growth conditions. Grown crystals were characterized by spectroscopy (XRD, FT-IR, UV-Vis) and optical microscopy. Combined density functional theory (DFT) and drift-diffusion modelling frameworks were simulated. These simulators were used to examine various perovskite absorbers for solar-cell configurations. Field calculations were used to examine the structural stability, band structure, and electronic contribution of the constituent elements in [(CH3)2NH2]Co1-nMn(HCOO)3 (M = Fe, Ni and n = 0, 0.1) as absorber material. Conventional TiO2 and spiro-OMeTAD were used as the electron-transport layer and hole-transport layer, respectively, and Pt was used as a back contact. Comprehensive analysis of the effects of several parameters (layer thickness, series and shunt resistances, temperature, generation-recombination rates, current-voltage density, quantum efficiency) was carried out using simulation. Our proposed strategy may pave the way for further design of new absorber materials for PSCs.

Biowaste to bioenergy nexus: Fostering sustainability and circular economy.

Existing fossil-based commercial products present a significant threat to the depletion of global natural resources and the conservation of the natural environment. Also, the ongoing generation of waste is giving rise to challenges in waste management. Conventional practices for the management of waste, for instance, incineration and landfilling, emit gases that contribute to global warming. Additionally, the need for energy is escalating rapidly due to the growing populace and industrialization. To address this escalating desire in a sustainable manner, access to clean and renewable sources of energy is imperative for long-term development of mankind. These interrelated challenges can be effectively tackled through the scientific application of biowaste-to-bioenergy technologies. The current article states an overview of the strategies and current status of these technologies, including anaerobic digestion, transesterification, photobiological hydrogen production, and alcoholic fermentation which are utilized to convert diverse biowastes such as agricultural and forest residues, animal waste, and municipal waste into bioenergy forms like bioelectricity, biodiesel, bio alcohol, and biogas. The successful implementation of these technologies requires the collaborative efforts of government, stakeholders, researchers, and scientists to enhance their practicability and widespread adoption.

Recent Advances of carbon Pathways for Sustainable Environment development.

Carbon dots (CDs) are an emerging type of carbon nanomaterial with strong biocompatibility, distinct chemical and physical properties, and low toxicity. CDs may emit fluorescence in the ultraviolet (UV) to near-infrared (NIR) range, which renders them beneficial for biomedical applications. CDs are usually made from carbon precursors and can be synthesized using top-down and bottom-up methods and it can be easily functionalized using different methods. For specific cases of biomedical applications carbon dot functionalization augments the materials' characteristics. Novel functionalization techniques are still being investigated. This review will look at the benefits of functionalization to attain a high yield and various biological applications. Biomedical applications such as photodynamic and photothermal therapy, biosensing, bioimaging, and antiviral and antibacterial properties will be covered in this review. The future applications of green synthesized carbon dots will be determined in part by this review.

Development of a microcantilever-based biosensor for detecting Programmed Death Ligand 1.

The ongoing global concern of cancer worldwide necessitates the development of advanced diagnostic and therapeutic strategies. The majority of recent detection strategies involve the employment of biomarkers. A critical biomarker for cancer immunotherapy efficacy and patient prognosis is Programmed Death Ligand 1 (PD-L1), which is a key immune checkpoint protein. PD-L1 can be particularly linked to cancer progression and therapy response. Current detection methods, such as enzyme-linked immunosorbent assay (ELISA), face limitations like high cost, time consumption, and complexity. This study introduces a microcantilever-based biosensor designed for the detection of soluble PD-L1 (sPD-L1), which has a specific association with PD-L1. The biosensor utilizes anti-PD-L1 as the sensing layer, capitalizing on the specific binding affinity between anti-PD-L1 and sPD-L1. The presence of the sensing layer was confirmed through Atomic Force Microscopy (AFM) and contact angle measurements. Binding between sPD-L1 and anti-PD-L1 induces a shift in the microcantilever's resonance frequency, which is proportional to the PD-L1 concentration. Notably, the resonance frequency shift demonstrates a robust linear relationship with the increasing biomarker concentration, ranging from 0.05 ng/ml to 500 ng/ml. The detection limit of the biosensor was determined to be approximately 10 pg/ml. The biosensor demonstrates excellent performance in detecting PD-L1 with high specificity even in complex biological matrices. This innovative approach not only provides a promising tool for early cancer diagnosis but also holds potential for monitoring immunotherapy efficacy, paving the way for personalized and effective cancer treatments.

Electro-sensing layer constructed of a WO3/CuO nanocomposite, for the electrochemical determination of 2-phenylphenol fungicide.

The abstract highlights the development of an electroanalytical sensor for the detection of 2-phenylphenol (2-PPL) as a contaminant. The novelty of the experiment lies in the utilization of a 1-D nanostructured WO3/CuO nanocomposite integrated with a carbon paste electrode (CPE). The hydrothermal method was used to synthesize the WO3 NPs, which were then characterized using Scanning electron microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDS) techniques. Tungsten oxides (WO3) have been the subject of extensive study because of their many desirable characteristics, including their ease of preparation, tunable stoichiometry, crystal structure, particle morphology, 2.6 eV bandgap, excellent photocatalytic oxidation capacity, non-toxic nature, and widespread availability. The narrow band gap in CuO makes it an ideal sensing material. Copper oxide has applications in many different industries because it is a semiconductor metal with a narrow band gap in the spectrum of 1.2-1.9 eV and unique optical, electrical, and magnetic properties. Techniques like cyclic voltammetry (CV), and square wave voltammetry (SWV) were used. Real sample analysis was carried out in real-world samples like different types of soil, vegetables, and water. The electroanalytical sensor showed outstanding catalytic behavior by enhancing the peak current of the 2-phenylphenol with the potential shift to the less positive side compared to the unmodified carbon paste electrode in the presence of pH 7.0 phosphate buffer solution (PB). Throughout the experimental study, double distilled was used. Various electro-kinetic parameters like pH, accumulation time study, scan rate, concentration variation, standard heterogeneous rate constant, and participation of electrons, accumulation time, and transfer coefficient have been studied at WO3/CuO/CPE. The limit of detection was quantified together with the limit of quantification. Possible electrochemical oxidation mechanism of the toxic molecule was depicted. Overall, this research contributes to the field of electroanalytical sensing and offers potential applications in environmental monitoring.

Viable remediation techniques to cleansing wastewaters comprising endocrine-disrupting compounds.

Endocrine-disrupting chemicals (EDCs) have recently gained prominence as emerging pollutants due to their significant negative impacts on diverse living forms in ecosystems, including humans, by altering their endocrine systems. EDCs are a prominent category of emerging contaminants in various aquatic settings. Given the growing population and limited access to freshwater resources, their expulsion from aquatic systems is also a severe issue. EDC removal from wastewater depends on the physicochemical properties of the specific EDCs found in each wastewater type and various aquatic environments. Due to these components' chemical, physical, and physicochemical diversity, various approaches based on physical, biological, electrochemical, and chemical procedures have been developed to eliminate them. The objective of this review is to provide the comprehensive overview by selecting recent approaches that showed significant impact on the best available methods for removing EDCs from various aquatic matrices. It is suggested that adsorption by carbon-based materials or bioresources is effective at higher EDC concentrations. Electrochemical mechanization works, but it requires expensive electrodes, continual energy, and chemicals. Due to the lack of chemicals and hazardous byproducts, adsorption and biodegradation are considered environmentally friendly. When combined with synthetic biology and an AI system, biodegradation can efficiently remove EDCs and replace conventional water treatment technologies in the near future. Hybrid in-house methods may reduce EDCs best, depending on the EDC and resources.

Comparison of Performance between Single- and Multiparameter Luminescence Thermometry Methods Based on the Mn5+ Near-Infrared Emission.

Herein, we investigate the performance of single- and multiparametric luminescence thermometry founded on the temperature-dependent spectral features of Ca6BaP4O17:Mn5+ near-infrared emission. The material was prepared by a conventional steady-state synthesis, and its photoluminescence emission was measured from 7500 to 10,000 cm-1 over the 293-373 K temperature range in 5 K increments. The spectra are composed of the emissions from 1E → 3A2 and 3T2 → 3A2 electronic transitions and Stokes and anti-Stokes vibronic sidebands at 320 cm-1 and 800 cm-1 from the maximum of 1E → 3A2 emission. Upon temperature increase, the 3T2 and Stokes bands gained in intensity while the maximum of 1E emission band is redshifted. We introduced the procedure for the linearization and feature scaling of input variables for linear multiparametric regression. Then, we experimentally determined accuracies and precisions of the luminescence thermometry based on luminescence intensity ratios between emissions from the 1E and 3T2 states, between Stokes and anti-Stokes emission sidebands, and at the 1E energy maximum. The multiparametric luminescence thermometry involving the same spectral features showed similar performance, comparable to the best single-parameter thermometry.

Detection of Aromatic Hydrocarbons in Aqueous Solutions Using Quartz Tuning Fork Sensors Modified with Calix[4]arene Methoxy Ester Self-Assembled Monolayers: Experimental and Density Functional Theory Study.

Quartz tuning forks (QTFs), which were coated with gold and with self-assembled monolayers (SAM) of a lower-rim functionalized calix[4]arene methoxy ester (CME), were used for the detection of benzene, toluene, and ethylbenzene in water samples. The QTF device was tested by measuring the respective frequency shifts obtained using small (100 µL) samples of aqueous benzene, toluene, and ethylbenzene at four different concentrations (10-12, 10-10, 10-8, and 10-6 M). The QTFs had lower limits of detection for all three aromatic hydrocarbons in the 10-14 M range, with the highest resonance frequency shifts (±5%) being shown for the corresponding 10-6 M solutions in the following order: benzene (199 Hz) > toluene (191 Hz) > ethylbenzene (149 Hz). The frequency shifts measured with the QTFs relative to that in deionized water were inversely proportional to the concentration/mass of the analytes. Insights into the effects of the alkyl groups of the aromatic hydrocarbons on the electronic interaction energies for their hypothetical 1:1 supramolecular host-guest binding with the CME sensing layer were obtained through density functional theory (DFT) calculations of the electronic interaction energies (ΔIEs) using B3LYP-D3/GenECP with a mixed basis set: LANL2DZ and 6-311++g(d,p), CAM-B3LYP/LANL2DZ, and PBE/LANL2DZ. The magnitudes of the ΔIEs were in the following order: [Au4-CME⊃[benzene] > [Au4-CME]⊃[toluene] > [Au4-CME]⊃[ethylbenzene]. The gas-phase BSSE-uncorrected ΔIE values for these complexes were higher, with values of -96.86, -87.80, and -79.33 kJ mol-1, respectively, and -86.39, -77.23, and -67.63 kJ mol-1, respectively, for the corresponding BSSE-corrected values using B3LYP-D3/GenECP with LANL2dZ and 6-311++g(d,p). The computational findings strongly support the experimental results, revealing the same trend in the ΔIEs for the proposed hypothetical binding modes between the tested analytes with the CME SAMs on the Au-QTF sensing surfaces.

Secondary Electrons in Gold Nanoparticle Clusters and Their Role in Therapeutic Ratio: The Outcome of a Monte Carlo Simulation Study.

Gold nanoparticles (GNPs) are used in proton therapy radio-sensitizers to help increase the dose of radiation to targeted tumors by the emission of secondary electrons. Thus, this study aimed to investigate the link between secondary electron yields produced from a nanoshell of GNPs and dose absorption according to the distance from the center of the nanoparticles by using a Monte Carlo model. Microscopic evaluation was performed by modeling the interactions of secondary electrons in a phase-space file (PSF), where the number of emitted electrons was calculated within a spherical GNP of 15 nm along with the absorbed dose near it. Then, the Geant4-DNA physics list was used to facilitate the tracking of low-energy electrons down to an energy below 50 eV in water. The results show a remarkable change in the number of secondary electrons, which can be compared at concentrations less than and greater than 5 mg/mL, with increased secondary electron production exhibited around NPs within a distance of 10-100 nm from the surface of all nanospheres. It was found that there was a steep dose enhancement drop-off up to a factor of dose enhancement factor (DFE) ≤ 1 within a short distance of 100 nm from the surface of the GNPs, which revealed that the dose enhancement existed locally at nanometer distances from the GNPs. Overall, our results indicate that the physical interactions of protons with GNP clusters should not be considered as being directly responsible for the radio-sensitization effect, but should be regarded as playing a major role in NP properties and concentrations, which has a subsequent impact on local dose enhancement.

Constructing a Visible-Active CoFe2O4@Bi2O3/NiO Nanoheterojunction as Magnetically Recoverable Photocatalyst with Boosted Ofloxacin Degradation Efficiency.

Constructing visible-light-active Z-scheme heterojunctions has proven fruitful in enhancing the photocatalytic activity of photocatalysts for superior water clean-up. Herein, we report the fabrication of a CoFe2O4@Bi2O3/NiO (CBN) Z-scheme nanoheterojunction. The obtained CBN heterojunction was used for visible-light-assisted degradation of ofloxacin (OFL) in water. The OFL degradation efficiency achieved by the CBN heterojunction was 95.2% in 90 min with a rate constant of kapp = 0.03316 min-1, which was about eight times that of NiO and thirty times that of CoFe2O4. The photocatalytic activity of a Bi2O3/NiO Z-scheme heterojunction was greatly enhanced by the visible activity and redox mediator effect of the cobalt ferrite co-catalyst. Higher charge-carrier separation, more visible-light capture, and the Z-scheme mechanism in the Z-scheme system were the important reasons for the high performance of CBN. The scavenging experiments suggested ●O2- as an active species for superior OFL degradation. The possible OFL degradation pathway was predicted based on LC-MS findings of degradation intermediate products. The magnetic nature of the CBN helped in the recovery of the catalyst after reuse for six cycles. This work provides new insights into designing oxide-based heterojunctions with high visible-light activity, magnetic character, and high redox capabilities for potential practical applications in environmental treatment.

Multi-walled carbon nanotube-based nanobiosensor for the detection of cadmium in water.

Industrial and agricultural processes have led to the prevalence of cadmium in the ecosystem. A successive build-up of cadmium in food and drinking water can result in inadvertent consumption of hazardous concentrations. Such environmental contamination of cadmium can pose a substantial threat to human and animal life. In humans, it is known to cause hypertension, cardiovascular diseases, DNA lesions, inhibition of DNA repair protein or disturb the functioning of lung, liver, prostate and kidney. The development of a reliable method for Cd (II) ions detection would reduce the exposure and complement existing conventional methods. In this study, a DNA based electrochemical method is employed for the detection of Cd (II) ions using ethyl green (EG) and multi-walled carbon nanotube (MWCNT). Glassy carbon electrode (GCE)/MWCNT forms the working electrode for differential pulse voltammetry (DPV) analysis for the detection of Cd (II) ions. The dsDNA is immobilized onto the working electrode. The indicator dye EG, preferably binds to ssDNA and its reduction peak current is noticeably less in the presence of dsDNA. The Cd (II) ions after interacting with dsDNA, unwinds the dsDNA to ssDNA, upon which the EG molecules bind to ssDNAs, giving a higher reduction peak current. The difference in the reduction peak currents in the presence and absence of Cd (II) ions is proportional to its concentration. The linear detection range achieved in this method is 2 nM-10.0 nM with a sensitivity of around 5 nA nM-1 and the limit of detection is 2 nM, which is less than the permissible limit of WHO for human exposure. This study considerably broadens the possible application of multi-walled carbon nanotube modified electrodes as biosensors and holds prospects for the detection of other heavy metals in environmental samples.

NH2-MIL-125(Ti) doped CdS/Graphene composite as electro and photo catalyst in basic medium under light irradiation.

The development of active electrocatalysts and photocatalysts for hydrogen evolution reaction (HER) and for environmental remediation is a huge challenge. Research is still underway on the development of low-cost catalytic materials with appreciable efficiency for HER. In the present study, a composite of metal organic framework (MOF) with CdS and graphene (NH2-MIL-125(Ti)/CdS-graphene) composites were developed with different loadings of graphene material via solvothermal technique. Further the electrocatalytic activity of the synthesized catalysts were investigated for HER and photocatalytic degradation of dye. Results show that the synthesized catalyst with a less amount of graphene was more active. HER results showed a less Tafel slope of 70.8 and 61.9 mVdec-1 with 15.6 mA/cm2 and 15.46 mA/cm2 current densities under light on and off conditions. Further the dye degradation activity of the synthesized catalysts was tested with Rhodamine B dye and results showed that the catalyst showed excellent activity for low weight loading of graphene with a degradation efficiency of 95 % and followed pseudo first order kinetic model. Overall results showed that the synthesized composites are promising for HER and photocatalytic applications.

Rapid and Sensitive Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Label-Free Manner Using Micromechanical Sensors.

Coronavirus (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as a deadly pandemic. The genomic analysis of SARS-CoV-2 is performed using a reverse transcription-polymerase chain reaction (RT-PCR) technique for identifying viral ribonucleic acid (RNA) in infected patients. However, the RT-PCR diagnostic technique is manually laborious and expensive; therefore, it is not readily accessible in every laboratory. Methodological simplification is crucial to combat the ongoing pandemic by introducing quick, efficient, and affordable diagnostic methods. Here, we report how microcantilever sensors offer promising opportunities for rapid COVID-19 detection. Our first attempt was to capture the single-stranded complementary DNA of SARS-CoV-2 through DNA hybridization. Therefore, the microcantilever surface was immobilized with an oligonucleotide probe and detected using complementary target DNA hybridization by a shift in microcantilever resonance frequency. Our results show that microcantilever sensors can discriminate between complementary and noncomplementary target DNA on a micro to nanoscale. Additionally, the microcantilever sensors' aptitude toward partial complementary DNA determines their potential to identify new variants of coronavirus. Therefore, microcantilever sensing could be a vital tool in the effort to extinguish the spreading COVID-19 pandemic.

The reaction of arylmethyl isocyanides and arylmethylamines with xanthate esters: a facile and unexpected synthesis of carbamothioates.

An unexpected formation of carbamothioates by a sodium hydride-mediated reaction of arylmethyl isocyanides with xanthate esters in DMF is reported. The products thus obtained were compared with the carbamothioates obtained by the sodium hydride-mediated condensation of the corresponding benzylamines and xanthate esters in DMF. To account for these unexpected reactions, a mechanism is proposed in which the key steps are supported by quantum chemical calculations.

Modeling of an Optically Heated MEMS-Based Micromechanical Bimaterial Sensor for Heat Capacitance Measurements of Single Biological Cells.

Detection of thermal activities of biological cells is important for biomedical and pharmaceutical applications because these activities are closely associated with the conformational change processes. Calorimetric measurements of biological systems using bimaterial microcantilevers (BMC) have increasingly been reported with the ultimate goal of developing highly sensitive and inexpensive techniques with real-time measurement capability techniques for the characterization of dynamic thermal properties of biological cells. BMCs have been established as highly sensitive calorimeters for the thermal analysis of cells and liquids. In this paper, we present a simulation model using COMSOL Multiphysics and a mathematical method to estimate the heat capacity of objects (treated here as a biological cell) placed on the surface of a microcantilever. By measuring the thermal time constant, which is obtained from the deflection curve of a BMC, the heat capacity of a sample can be evaluated. With this model, we can estimate the heat capacity of single biological cells using a BMC, which can potentially be used for the thermal characterization of different biological samples.

Calixazulenes: azulene-based calixarene analogues - an overview and recent supramolecular complexation studies.

Some of the least studied calixarenes are those that consist of azulene rings bridged by -CH2- groups. Since Lash and Colby's discovery of a simple and convenient method for producing the parent all-hydrocarbon calix[4]azulene, there have been two other all-hydrocarbon calix[4]azulenes which have been synthesized in good yields by their method. This allowed studying their supramolecular properties. This report is of our latest work on the solution-state supramolecular complexation of one of these calix[4]azulenes, namely tetrakis(5,7-diphenyl)calix[4]azulene or "OPC4A", with several electron-deficient tetraalkyammonium salts. As a result of more recent methods developed by us and others employing Suzuki-Miyaura cross-coupling reactions to produce additional functionalized azulenes, the promise of further greater functionalized calixazulenes lies in store to be investigated.

Efficient cationic dye removal from water through Arachis hypogaea skin-derived carbon nanospheres: a rapid and sustainable approach.

The present study investigates the potential of Arachis hypogaea skin-derived carbon nanospheres (CNSs) as an efficient adsorbent for the rapid removal of cationic dyes from aqueous solutions. The CNSs were synthesized through a facile, cost-effective, catalyst-free and environmentally friendly process, utilizing Arachis hypogaea skin waste as a precursor. This is the first reported study on the synthesis of mesoporous carbon nanospheres from Arachis hypogaea skin. The structural and morphological characteristics of the CNSs were confirmed by different nano-characterization techniques. The adsorption performance of the carbon nanospheres was evaluated through batch adsorption experiments using two cationic dyes-methylene blue (MB) and malachite green (MG). The effects of the initial dye concentration, contact time, adsorbent dosage, and pH were investigated to determine the optimal conditions for dye removal. The results revealed that the obtained CNSs exhibited remarkable adsorption capacity and rapid adsorption kinetics. Up to ∼98% removal efficiency was noted for both dyes in as little as 2 min for a 5 mg L-1 dye concentration, and the CNSs maintained their structural morphology even after adsorption. The adsorption data were fitted to various kinetic and isotherm models to gain insights into the adsorption mechanism and behaviour. The pseudo-second-order kinetic model and Redlich-Peterson model best described the experimental data, indicating multi-layer adsorption and chemisorption as the predominant adsorption mechanism. The maximum adsorption capacity was determined to be 1128.46 mg g-1 for MB and 387.6 mg g-1 for MG, highlighting the high affinity of the carbon nanospheres towards cationic dyes. Moreover, CNS reusability and stability were examined through desorption and regeneration experiments, which revealed sustained efficiency over 7 cycles. CNSs were immobilised in a membrane matrix and examined for adsorption, which demonstrated acceptable efficiency values and opened the door for further improvement.

Carbon Nanomaterials for Biomedical Applications: Progress and Outlook.

Recent developments in nanoscale materials have found extensive use in various fields, especially in the biomedical industry. Several substantial obstacles must be overcome, particularly those related to nanostructured materials in biomedicine, before they can be used in therapeutic applications. Significant concerns in biomedicine include biological processes, adaptability, toxic effects, and nano-biointerfacial properties. Biomedical researchers have difficulty choosing suitable materials for drug carriers, cancer treatment, and antiviral uses. Carbon nanomaterials are among the various nanoparticle forms that are continually receiving interest for biomedical applications. They are suitable materials owing to their distinctive physical and chemical properties, such as electrical, high-temperature, mechanical, and optical diversification. An individualized, controlled, dependable, low-carcinogenic, target-specific drug delivery system can diagnose and treat infections in biomedical applications. The variety of carbon materials at the nanoscale is remarkable. Allotropes and other forms of the same element, carbon, are represented in nanoscale dimensions. These show promise for a wide range of applications. Carbon nanostructured materials with exceptional mechanical, electrical, and thermal properties include graphene and carbon nanotubes. They can potentially revolutionize industries, including electronics, energy, and medicine. Ongoing investigation and expansion efforts continue to unlock possibilities for these materials, making them a key player in shaping the future of advanced technology. Carbon nanostructured materials explore the potential positive effects of reducing the greenhouse effect. The current state of nanostructured materials in the biomedical sector is covered in this review, along with their synthesis techniques and potential uses.