RESUMEN
Insulin resistance (IR) is the corner stone of metabolic obesity. This cross-sectional analytical study was aimed to find out the frequency of IR in non-diabetic adult individuals of different obesity phenotypes that would help to implement preventive measures to avoid the cardiometabolic catastrophes. METHODS: Total 955 nondiabetic adult individuals were selected and categorized into six metabolic phenotypes by metabolic syndrome criteria in each BMI group (18.5-24.9-normal weight, 25-29.9-overweight, ≥30-obese). From them, metabolically obese normal weight, metabolically obese overweight, metabolically healthy obese and metabolically unhealthy obese were selected as Obesity phenotypes (Nâ¯=â¯616). RESULTS: The frequency of IR was found to be very high (60.2%) in total nondiabetic adult obese individuals (Nâ¯=â¯616). Highest frequency of IR was found in MUO phenotype (76.3%), lowest frequency of IR was found in MONW phenotype (37.1%) and frequency of IR in MOOW and MHO phenotypes found to be identical but significantly (pâ¯<â¯0.0001) less than MUO and significantly (pâ¯<â¯0.0001) more than MONW phenotype. Among the obesity phenotypes, females were more insulin resistant than males (67.5% vs 48.1% respectively, pâ¯<â¯0.05). Frequency of IR found significantly (pâ¯<â¯0.05) more in female than male in all obesity phenotypes except in MUO phenotype where males found to show significantly (pâ¯<â¯0.05) higher frequency than females. Frequency of IR was significantly higher in younger (20-39â¯yrs) age group than 40-60â¯yrs age group (63.2% vs 53.5% respectively, pâ¯<â¯0.05). CONCLUSION: IR is alarmingly high (60.2%) in nondiabetic adult obese individuals. Among different obesity phenotypes, it is highest (76.3%) in MUO and lowest (37.1%) in MONW.