RESUMEN
The in vitro activity of daptomycin was evaluated against 360 multidrug-resistant Staphylococcus aureus isolates (including hospital-acquired isolates) and multidrug-susceptible community-acquired methicillin-resistant S. aureus with known virulence genes. All isolates were inhibited at Asunto(s)
Antibacterianos/farmacología
, Daptomicina/farmacología
, Farmacorresistencia Bacteriana Múltiple
, Resistencia a la Meticilina
, Staphylococcus aureus/efectos de los fármacos
, Factores de Virulencia/análisis
, Infecciones Comunitarias Adquiridas/microbiología
, Infección Hospitalaria/microbiología
, Humanos
, Pruebas de Sensibilidad Microbiana
, Infecciones Estafilocócicas/microbiología
, Staphylococcus aureus/aislamiento & purificación
RESUMEN
An initiative was taken to determine the in vitro activity of daptomycin against 85 Gram-positive isolates with reduced susceptibilities to linezolid and quinupristin/dalfopristin. Daptomycin had potent activity against all strains, with a Staphylococcus spp. minimum inhibitory concentration (MIC) < or =2 microg/mL and an Enterococcus spp. MIC < or =8 microg/mL. Resistance to linezolid and quinupristin/dalfopristin appears to be independent of reduced susceptibility to daptomycin.