Temporary organ substitution by hemoperfusion through suspension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency.

The results of intensive therapy and temporary organ substitution by hemoperfusion through a suspension of active hepatocytes in 126 patients suffering from acute hepatic insufficiency (AHI) induced by virus B hepatitis, virus non-A, non-B hepatitis, acute toxic hepatitis, active liver cirrhosis, sepsis leptospirosis long-term subhepatic jaundice are presented in this paper. Hepatic encephalopathia confirmed both clinically and electroencephalographically was registered in all the patients. The patients were subdivided into two groups: a complex of commonly used curative measures according to the intensive therapy for AHI was applied in Group A (67 patients); in Group B (59 patients), alongside with the above measures, temporary organ substitution by hemoperfusion through a suspension of active porky hepatocytes was also performed. The lethality in Group A made up 59% and that in Group B was 37%.

[Hemoperfusion through adsorbents as a method of preoperative preparation of patients with severe form of mechanical jaundice]. / Gemoperfuziia cherez adsorbenty kak metod predoperatsionnoi podgotovki bol'nykh s tiazheloi formoi mekhanicheskoi zheltukhi.

The method of haemoperfusion through the ion exchange resin and active carbon was used 15 times in 13 patients with heavy forms of mechanical subhepatogenous jaundice. The haemoperfusion was used as a method of preoperative preparation for reduction of hyperbilirubinemia and cholemic intoxication and for prevention of possible postoperative complications. One patient recovered. One patient died of progressing hepatic insufficiency. The rest of the patients were subjected to surgical interventions for the main disease.

[Evaluation of the functional activity of the liver following its heterotopic transplantation in experimental acute hepatic insufficiency]. / Otsenka funktsional'noi aktivnosti pecheni posle ee geterotopicheskoi peresadki pri éksperimental'noi ostroi pechenochnoi nedostatochnosti.

The functional activity of the transplanted (additional) liver and its efficiency in the treatment of critical hepatic insufficiency was studied in experiments on dogs. Without an immunosuppression being used the additionally transplanted liver manifests its functional activity in the recipient's organism within 4 days and is able to support the animal's life for 3-4 days.

[Surgical aspects of a temporary heterotopic transplantation of the liver]. / Khirurgicheskie aspekty vremennoi geterotopicheskoi peresadki pecheni.

The ways of settling some surgical aspects of a temporary heterotopic transplantation of the liver are analysed in the article. According to the obtained data the placement of the graft into the iliac zone of the abdominal cavity is the most convenient for a temporary heterotopic transplantation of an additional liver. An adequate vascularization of the additional organ can be effected via hepatic artery, which simplifies considerably the removal and replacement of this organ. For a free placement of the graft the weight of the donor should be 2 or 3 times less than that of the recipient.

[The use of hemoperfusion through a suspension of cryopreserved hepatocytes in acute liver failure]. / Primenenie gemoperfuzii cherez vzves' kriokonservirovannykh gepatotsitov pri ostroi pechenochnoi nedostatochnosti.

The present work deals with results of intensive therapy and temporary organ substitution by using hemoperfusion through a suspension of living donor hepatocytes in 71 patients with acute hepatic insufficiency. Hemoperfusion was performed through a suspension of fresh living hepatocytes or through a suspension of cryo-conserved (during 60 days) living hepatocytes. Lethality was 37-42%.