RESUMEN
BACKGROUND: This study was aimed at identifying the prevalence, distribution, and clinicopathologic characteristic of colonic polyps among Nigerians undergoing colonoscopy at the Obafemi Awolowo University Teaching Hospitals complex, Ile-Ife, Nigeria. We also determined the polyp detection rate (PDR), polyps per colonoscopy (PPC) and adenoma detection rate (ADR). MATERIALS AND METHODS: This is a prospective study of all colonoscopy examinations performed at the endoscopy unit of our hospital from January, 2007 to December 2013. The patient demographics, indications for colonoscopy, colonoscopic findings, number of the polyps, their sizes, possible risk factors in the individual case histories, and histopathological characteristics of the polyps. RESULTS: During the study period, a total of 415 patients met the inclusion criteria and only 67 out of these had colonic polyps. The overall PDR was 16.1%. The age ranged was 2-87 years with a median of 57 years. Forty-three (64.2%) patients were 50 years or above and there were 40 (59.7%) males. Thirty-three (49.3%) patients were referred as a result of lower gastrointestinal bleeding, 14 (20.9%) for colorectal cancer (CRC) and 13 (19.4%) for routine screening. Thirty-nine (58.2%) patients had the polyps at the rectosigmoid region of the colon, 17 (25.4%) had the polyps located proximal to sigmoid colon and 11 (16.4%) patients had multiple polyps involving both segments. Adenomatous polyps was the most common (28 [47.5%]) histopathological finding of which two patients had adenomatous polyposis. Other findings include inflammatory polyps in 17 (18.8%) patients, 5 (8.5%) patients each had hyperplastic and malignant polyps, while 4 (6.8%) patients had juvenile polyps. The ADR was 6.8 and the PPC was 0.2. Statistically, patients 50 years and older were more likely to have adenomatous and hyperplastic polyps than those younger than this age (P = 0.010). CONCLUSION: We conclude that polyps are probably not as rare among black Africans especially when they are above 50 years. Our histopathological finding of adenomatous change in a good proportion of the detected polyps show that they are likely to be associated with CRCs in our compatriots and as such we would recommend a routine screening colonoscopy for Nigerians aged 50 and above.
Asunto(s)
Adenoma/epidemiología , Pólipos del Colon/epidemiología , Colonoscopía , Neoplasias Colorrectales/epidemiología , Hemorragia Gastrointestinal/epidemiología , Adenoma/diagnóstico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Pólipos del Colon/diagnóstico , Neoplasias Colorrectales/diagnóstico , Femenino , Hemorragia Gastrointestinal/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Nigeria/epidemiología , Prevalencia , Estudios Prospectivos , Recto/patología , Estudios Retrospectivos , Adulto JovenRESUMEN
BACKGROUND: Colonic diverticular disease is one of the most common and costly gastrointestinal disorders among industrialized societies, which have recently been described among Africans. Presentations and distribution pattern of the disease among Africans appeared to be different from that described among the Western population. We embark on this study aimed at evaluating the presentation, distribution pattern, and the management of diverticulosis in our tertiary health facility. MATERIALS AND METHODS: A prospective descriptive study of the cases of diverticular disease seen between January 2007 and December 2011 at Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria. RESULTS: During the 5-year study period, 40 cases were seen. The patients were aged 41-85 years with a median age of 64 years. There were 29 (72.5%) male and 11 (27.5%) female with an average male to female ratio of 3:1. The most common presentation was bleeding per rectum in 28 (70%) patients, which mostly needed transfusion. Ten (25%) patients presented with recurring abdominal pain, whereas one (2.5%) patient presented with abdominal mass and features of intestinal obstruction. Thirty patients were diagnosed on colonoscopy, eight on barium enema, and two on computerized tomography scan. Thirty-four (85%) patients had a pancolonic disease. All the patients were placed on high fiber diet and antibiotics namely ciprofloxacin and metronidazole. Five patients had recurrence within 6 months of follow up, of which one had emergency colectomy. CONCLUSION: Diverticular disease is no longer a rare disease in Nigeria. It is a common cause of lower gastrointestinal bleeding in elderly patients. High index of suspicion for diverticular disease of the colon and its complications should increase in the country.
Asunto(s)
Dolor Abdominal/etiología , Diverticulosis del Colon/diagnóstico , Diverticulosis del Colon/terapia , Hemorragia Gastrointestinal/etiología , Adulto , Anciano , Anciano de 80 o más Años , Antiinfecciosos/uso terapéutico , Ciprofloxacina/uso terapéutico , Fibras de la Dieta/administración & dosificación , Diverticulosis del Colon/complicaciones , Femenino , Hemorragia Gastrointestinal/terapia , Humanos , Masculino , Metronidazol/uso terapéutico , Persona de Mediana Edad , Nigeria , Estudios ProspectivosRESUMEN
AIMS AND OBJECTIVES: To investigate the frequency of precancerous lesions in H. pylori gastritis in Nigerians MATERIALS AND METHODS: Previously, the slides of all endoscopic gastroduodenal biopsies seen at the Pathology Department of Obafemi Awolowo University Teaching Hospital, Ile-Ife between 1994 and 2003 were reviewed and published. The current review examined interplay of intestinal metaplasia, glandular atrophy and epithelial dysplasia with H.pylori. The H.pylori, intestinal metaplasia and glandular atrophy were graded based on updated Sydney classification scheme while Vienna classification was used for dysplasia. RESULTS: Out of 1036 biopsies seen during the study period, 135 (13%) had associated precancerous lesions. Intestinal metaplasia was the commonest (9.2%), followed by severe atrophic gastritis (4.3%) and low grade dysplasia (0.7%) occurring either alone or in various combinations. Most of these lesions were seen in patients above 40 years of age and over 80% were H.pylori positive. CONCLUSION: Frequency of precancerous lesions is low among Nigerians with H.pylori gastritis. Intestinal metaplasia was the commonest lesion and was mostly type I with relatively low risk for gastric cancer development. The relatively high prevalence H.pylori infection among these cases could have resulted from repeated infection and most were localised to the corpus relative to the antral region where the precancerous lesions were seen.
Asunto(s)
Adenocarcinoma/epidemiología , Gastritis/epidemiología , Lesiones Precancerosas/epidemiología , Neoplasias Gástricas/epidemiología , Adenocarcinoma/patología , Adulto , Anciano , Biopsia , Femenino , Mucosa Gástrica/patología , Gastritis/patología , Gastritis Atrófica/epidemiología , Gastritis Atrófica/patología , Gastroscopía , Infecciones por Helicobacter/epidemiología , Helicobacter pylori , Humanos , Masculino , Metaplasia/epidemiología , Metaplasia/patología , Persona de Mediana Edad , Lesiones Precancerosas/patología , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Índice de Severidad de la Enfermedad , Neoplasias Gástricas/patologíaRESUMEN
AIMS AND OBJECTIVES: Lower gastrointestinal (LGI) diseases are the leading causes of morbidity and mortality worldwide. Colonoscopy holds an important place in screening, diagnosing and treatment of these conditions. In Nigeria, as in many other developing countries, the facility for performing colonoscopy is rarely available. This prospective report seeks to evaluate the demographic data of patients presenting for colonoscopy, the pattern and validity of referral diagnosis versus colonoscopy findings in Ile-Ife, Nigeria. SUBJECTS AND METHODS: All patients who had colonoscopy procedure done in the Endoscopy Unit of Obafemi Awolowo University Teaching Hospital Complex between January 2007 and December 2011 were included in the study. RESULTS: During the study period, colonoscopy was carried out in 320 patients. One hundred and eighty two (56.9%) were males, while 138 (43.1%) were females. The median age was 59.5 years. Their ages ranged from 2-87 years. The most common indications were lower gastrointestinal bleeding and change in bowel habit which together accounted for 79.0%. No abnormality was seen in 93(29.1%) patients. Abnormal endoscopic findings included 66(20.6%) patients who had haemorrhoids, 50(15.6%) cases colorectal cancer, 33 (10.3%) patients had benign polyps and (30 (9.4%) patients had diverticular disease. Other findings were colitis, inflammatory bowel disease, rectovaginal fistula, vascular ectasia and extra luminal compression. Haemorrhoids, diverticulosis and polyps were the most common findings in patients presenting with lower gastrointestinal bleeding. CONCLUSION: This present report showed that colonoscopy is a cheap, safe and effective method of investigating lower gastrointestinal disease in Ile-Ife, Nigeria. When the indication is based on symptoms, the diagnostic yield could be as high as 90%. The common causes of lower gastrointestinal bleeding in Ile-Ife, Nigeria include haemorrhoids, diverticulosis and polyps.
Asunto(s)
Colonoscopía , Hemorragia Gastrointestinal/diagnóstico , Enfermedades Intestinales/diagnóstico , Tracto Gastrointestinal Inferior/patología , Adulto , Distribución por Edad , Anciano , Colonoscopía/economía , Colonoscopía/métodos , Colonoscopía/estadística & datos numéricos , Análisis Costo-Beneficio , Femenino , Hemorragia Gastrointestinal/etiología , Humanos , Enfermedades Intestinales/clasificación , Enfermedades Intestinales/complicaciones , Enfermedades Intestinales/epidemiología , Masculino , Persona de Mediana Edad , Nigeria/epidemiología , Estudios Prospectivos , Derivación y Consulta/estadística & datos numéricos , Reproducibilidad de los Resultados , Distribución por SexoRESUMEN
BACKGROUND: Colonoscopy is considered to be the gold standard investigation for assessing the colonic mucosa. Good bowel preparation is essential in order to achieve optimal visualisation of the mucosa. Traditionally water enema is used for bowel preparation in most centres in Nigeria. This prospective study was performed at the Gastrointestinal Endoscopy Unit of Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria between July 2008 and June 2009. AIMS AND OBJECTIVES: This study compared patients' tolerability, adverse effects, efficacy and mean duration of colonoscopy of water enema and sodium phosphate (NaP) for bowel preparation toward colonoscopy. PATIENTS AND METHODS: Standard structured questionnaire was completed by 64 patients and the colonoscopist assessing tolerability, adverse effect, efficacy and mean duration of the procedure. RESULTS: There were sixty four patients aged between 22 to 86 years. The mean age was 58.16 ± 15.790. Thirty eight (59.4%) patients were in patients and 26 (40.6%) were out patients. Forty one (64.1%) patients had water enema while 23 (35.9%) patients were included in the NaP group. The median age for patients in both groups was 62.0 years. Patients in NaP group rated their bowel preparation as more tolerable and found the dietary restriction much easier than those in water enema group (p < 0.0001). Better colon cleansing score was found in patient in NaP group as compared with those in water enema group in all region of the colon. The procedure took significantly longer time in patients in water enema group as compared with those in NaP group (p < 0.0001). CONCLUSION: NaP has a better bowel cleansing score for colonoscopy than water. It has better tolerability, side effect profile, efficacy and gives a shorter mean duration for the procedure.
Asunto(s)
Catárticos/administración & dosificación , Enfermedades del Colon/diagnóstico , Colonoscopía , Enema , Fosfatos/administración & dosificación , Administración Oral , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Satisfacción del Paciente , Estudios Prospectivos , Irrigación Terapéutica/métodos , Factores de Tiempo , Adulto JovenRESUMEN
A total of 186 Helicobacter pylori isolates and 532 gastric biopsies recovered from 532 patients with varying degrees of gastroduodenal pathology are subjected to in vitro antibiotic susceptibility testing using the disc-diffusion method, Etest (MIC breakpoints) and molecular testing using the polymerase chain reaction (PCR). In the isolates studied, antibiotic resistance was as follows: piperacillin (72%), amoxicillin (66%), erythromycin (78%), tetracycline (100%) and metronidazole (95%). All isolates were sensitive to ofloxacin, ciprofloxacin and norfloxacin. None of the 245 amplicons (positive for H. pylori) from the biopsies were digested with the Bbs1 and Bsal restriction enzyme used in the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, showing sensitivity to clarithromycin. However, a 238 bp fragment from H. pylori chromosomal DNA (corresponding to the quinolone resistance determining region [QRDR]) of the gyrA gene was amplified successfully. Twelve (4.9%) of the 245 strains studied had the described mutation at position 91, from asparagine (Asn) to glycine (Gly). The study showed that all the H. pylori strains were sensitive to clarithromycin and ciprofloxacin. It also highlighted PCR as a potential tool for faster diagnosis and determination of antibiotic susceptibility (within 24 h) of H. pylori from biopsies and/or isolates recovered from peptic ulcer and gastritis patients.
Asunto(s)
Antibacterianos/farmacología , Farmacorresistencia Bacteriana Múltiple/genética , Infecciones por Helicobacter/tratamiento farmacológico , Helicobacter pylori/efectos de los fármacos , Amoxicilina/farmacología , Antibacterianos/uso terapéutico , Biopsia , Ciprofloxacina/farmacología , Ciprofloxacina/uso terapéutico , Claritromicina/farmacología , Claritromicina/uso terapéutico , ADN Bacteriano/genética , Dispepsia/tratamiento farmacológico , Dispepsia/microbiología , Infecciones por Helicobacter/microbiología , Infecciones por Helicobacter/patología , Helicobacter pylori/genética , Helicobacter pylori/aislamiento & purificación , Humanos , Metronidazol/farmacología , Metronidazol/uso terapéutico , Pruebas de Sensibilidad Microbiana/métodos , Pruebas de Sensibilidad Microbiana/estadística & datos numéricos , Nigeria , Úlcera Péptica/microbiología , Reacción en Cadena de la Polimerasa , Estómago/microbiología , Estómago/patología , Tetraciclina/farmacología , Tetraciclina/uso terapéuticoRESUMEN
OBJECTIVE: Morphologic changes seen in the endoscopic biopsies are dynamic and could be predictive of more important sequelae of chronic H. pylori gastritis such as gastric carcinoma and lymphoma. The objective of the study was to review the biopsy appearances of endoscopic gastroduodenal biopsies using the updated Sydney System of classification in order to throw some light on the biology of gastroduodenitis. METHODS: A retrospective review of all endoscopic gastroduodenal biopsies received in the department of Morbid Anatomy of Obafemi Awolowo University Teaching Hospitals Complex between 1994 and 2003 was undertaken. Grading of the chronicity, activity, atrophy, H. pylori density and metaplasia were done using the updated Sydney System of classification and grading. RESULTS: A total of 1047 gastric and 47 duodenal biopsies from 1047 patients were reviewed. There was evidence of significant chronic gastritis in 98.1% of the gastric biopsies and in 78.0% of these, H. pylori was the main identifiable aetiological agent. Marked atrophic changes and intestinal metaplasia that are known to predispose to gastric malignances were seen in 4.9% and 9.3% of our cases respectively. Chronic duodenitis was seen in 83% of the duodenal biopsies and in 29.6%, H. pylori was seen on a background of gastric metaplasia. CONCLUSION: The prevalence of H. pylori was high and it was the single most important aetiological factor responsible for the biopsy changes associated with chronic gastroduodenitis.
Asunto(s)
Duodenitis/patología , Gastritis/patología , Infecciones por Helicobacter/patología , Helicobacter pylori/aislamiento & purificación , Adolescente , Adulto , Distribución por Edad , Anciano , Biopsia , Niño , Preescolar , Enfermedad Crónica , Duodenitis/microbiología , Endoscopía , Femenino , Gastritis/microbiología , Infecciones por Helicobacter/complicaciones , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Nigeria , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Adulto JovenRESUMEN
Gastric mucosal biopsies of 77 dyspeptic patients whose endoscopic features were suggestive of cancer and 56 patients with uncomplicated duodenal ulcer (DU) were subjected to histopathological analysis. Gastric cancer was confirmed in 18 (23.4%) of the 77 patients but not in 59 (76.6%). 4 (5.2%) of the 18 patients had early gastric cancer (EGC). Histopathological findings in the stomach biopsy of the 59 patients in whom cancer could not be confirmed were compared with those of the 56 patients with DU. Intestinal metaplasia (IM) was present in 32.2% of the 59 cases with endoscopic suspicion of gastric cancer and in 16.1% of the 56 DU controls (P < 0.05). Mucosa-associated lymphoid tissue (MALT) occurred in 28.8% of the cancer-resembling cases and in 12.5% of the DU patients (P < 0.05). The difference in the prevalence of gastric mucosal atrophy and Helicobacter pylori infection between the two groups (83% vs. 71.4%) did not reach statistical significance (P > 0.10). All 18 patients with gastric cancer were positive for Helicobacter pylori and the prevalence of the infection approached 95% in those with IM and MALT. This study shows that IM and MALT present with endoscopic appearances that resemble that of gastric cancer and that along with the latter, their main aetiological agent is Helicobacter pylori.
Asunto(s)
Mucosa Gástrica/patología , Gastroscopía , Linfoma de Células B de la Zona Marginal/diagnóstico , Adenocarcinoma/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Dispepsia/etiología , Femenino , Mucosa Gástrica/microbiología , Infecciones por Helicobacter/epidemiología , Helicobacter pylori/aislamiento & purificación , Humanos , Masculino , Persona de Mediana Edad , Nigeria , Estudios Prospectivos , Neoplasias GástricasRESUMEN
Kaposi's sarcoma (KS) was previously a relatively rare disease. With the advent of HIV/AIDS pandemic however, AIDS-related KS has been on the increase and so has interest in the disease. Ninety per cent of patients with KS present with skin lesions. While the gastrointestinal tract is a fairly common site of metastatic KS, primary gastrointestinal KS is uncommon. The presentation of gastrointestinal KS with severe gastrointestinal bleeding is rarer still. In this report, we present a 56yr old HIV-negative patient who presented with severe gastrointestinal bleeding without any skin lesions. Multiple haemorrhagic polypoidal lesions were found on the walls of the jejunum and ileum as well as the liver at exploratory laparotomy and these were found to be KS on histopathologic examination. We also discuss the diagnostic and therapeutic challenges we had with this rare cause of severe GI bleeding.
Asunto(s)
Hemorragia Gastrointestinal/etiología , Neoplasias del Íleon/diagnóstico , Neoplasias del Yeyuno/diagnóstico , Sarcoma de Kaposi/diagnóstico , Hemorragia Gastrointestinal/terapia , Humanos , Neoplasias del Íleon/complicaciones , Neoplasias del Íleon/terapia , Neoplasias del Yeyuno/complicaciones , Neoplasias del Yeyuno/terapia , Masculino , Persona de Mediana Edad , Sarcoma de Kaposi/complicaciones , Sarcoma de Kaposi/terapiaRESUMEN
AIM: To comparatively evaluate PCR and other diagnostic methods (the rapid urease test and / or culture) in order to determine which of the three PCR methods (ureA, glmM and 26-kDa, SSA gene) was most appropriate in the diagnosis of Helicobacter pylori (H pylori ) infection and also to evaluate the detection of a putative virulence marker of H pylori, the cagA gene, by PCR in biopsy specimens. METHODS: One hundred and eighty-nine biopsy specimens were collected from 63 patients (three biopsies each) undergoing upper gastroduodenal endoscopy for various dyspeptic symptoms. The PCR methods used to detect H pylori DNA directly from biopsies were the glmM, 26-kDa, ureA and then cagA was used to compare the culture technique and CLO for urease with the culture technique being used as the gold standard. RESULTS: Thirty-five percent of the biopsies were positive for H pylori DNA using the 3 PCR methods, while 68% of these were positive for the cagA gene. Twenty-four percent of the biopsies were negative for H pylori DNA in all PCR methods screened. The remaining 41% were either positive for ureA gene only, glmM only, 26-kDa only, or ureA + glmM, ureA + 26-kDa, glmM + 26-kDa. Out of the 35% positive biopsies, 41% and 82% were positive by culture and CLO respectively, while all negative biopsies were also negative by culture and cagA. Cag A+ infection was also predominantly found in H pylori DNA of the biopsies irrespective of the clinical diagnosis. CONCLUSION: This method is useful for correctly identifying infections caused by H pylori and can be easily applied in our laboratory for diagnostic purposes.
Asunto(s)
Antígenos Bacterianos/genética , Proteínas Bacterianas/genética , Infecciones por Helicobacter/patología , Helicobacter pylori/aislamiento & purificación , Reacción en Cadena de la Polimerasa/métodos , Biopsia , Mucosa Gástrica/microbiología , Mucosa Gástrica/patología , Infecciones por Helicobacter/microbiología , Helicobacter pylori/genética , Helicobacter pylori/patogenicidad , Humanos , Fosfoglucomutasa/genética , Sensibilidad y Especificidad , Ureasa/genética , VirulenciaRESUMEN
It is generally believed that colonic neoplasms are uncommon amongst Blacks. One hundred and twenty seven cases of large bowel neoplasms were treated at Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife between 1981 and 1990. There were 84 males and 43 females. The mean age was 53 years. Duration of illness prior to presentation at the hospital varied between two weeks to three years with a mean time lag of 15 months. Intestinal obstruction was found in 83 patients and these also presented with anaemia. However massive rectal bleeding was noticed only in 38 cases. Most of the lesions were rectosigmoid. Some of these patients accounting for 87 cases (69 pc) refused permanent colostomy due to social embarrassment. Histopathologic appearance of the tumours were mostly adenocarcinoma in 97 cases. Thirty five patients died within the first year of their presentation and management. Twenty eight patients are still being followed up while other patients have been lost to follow up. This study shows that a sizeable number of patients suffer from colonic neoplasm in our community.
Asunto(s)
Adenocarcinoma/epidemiología , Población Negra , Neoplasias del Colon/epidemiología , Vigilancia de la Población , Adenocarcinoma/complicaciones , Adenocarcinoma/cirugía , Adulto , Anciano , Anemia/etiología , Colectomía , Neoplasias del Colon/complicaciones , Neoplasias del Colon/cirugía , Colostomía , Femenino , Estudios de Seguimiento , Hemorragia Gastrointestinal/etiología , Humanos , Obstrucción Intestinal/etiología , Masculino , Persona de Mediana Edad , Nigeria/epidemiología , Tasa de SupervivenciaRESUMEN
Over 75 pc of 138 patients prospectively studied tolerated field block local anaesthesia for inguinal herniorrhaphy. This tolerance was, however, lower in the younger age groups. There were few complications and patients were discharged within 24 to 72 hours.
Asunto(s)
Anestesia Local/métodos , Hernia Inguinal/cirugía , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Anestesia Local/efectos adversos , Femenino , Humanos , Tiempo de Internación , Masculino , Persona de Mediana Edad , Nigeria , Estudios ProspectivosRESUMEN
Gastroscopy is the preferred method of diagnosis of upper gastrointestinal (UGI) disorders which often present with dyspepsia. Since the discovery of helicobacter pylori (H. pylori) as an important aetiological agent in gastroduodenal disease, investigation for this organism during UGI endoscopy has become a standard clinical practice. We have studied a large number of Nigerian patients with dyspeptic symptoms referred for endoscopy for the spectrum of gastroduodenal diseases and the incidence of H. pylori infection. Detection of H. pylori was done on gastric muscosal biopsies either by the Campylobacter-Like Organism (CLO)-urease test or by histropathology. A total of 834 patients were studied out of which 268 were investigated for H. pylori. A hundred and ninety-five patients (73%) were positive for H. pylori and the peak age was in the fourth decade. Duodenal ulcer (DU) was the most common endoscopic finding (38.7%). The incidence of H. pylori infection was 76% among patients with DU, gastritis, gastroduodenitis and gastric outlet obstruction. However, all the anterior and pyloric channel Duus tested for H. pylori were positive gastric ulcer (GU) was diagnosed in only 4.7% of patients but 82% of them tested for H. pylori were positive. H. pylori was significantly associated with GU occurring with gastritis. Gastric carcinoma was diagnosed in 52 patients (6.2%) and 50% of those tested for H. pylori were positive. This study shows that H. pylori plays an important role in the aetiopathogenesis of peptic ulcer disease among Nigerian patients and that the diagnosis of anterior and pyloric channel Duus or gastroesophageal polyp disease may be an indicator of massive H. pylori infection.
Asunto(s)
Población Negra , Úlcera Duodenal/microbiología , Dispepsia/microbiología , Esofagitis/microbiología , Obstrucción de la Salida Gástrica/microbiología , Gastritis/microbiología , Infecciones por Helicobacter/complicaciones , Infecciones por Helicobacter/epidemiología , Helicobacter pylori , Adolescente , Adulto , Distribución por Edad , Anciano , Anciano de 80 o más Años , Biopsia , Niño , Endoscopía del Sistema Digestivo , Femenino , Gastroscopía , Infecciones por Helicobacter/diagnóstico , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Nigeria/epidemiología , Estudios Prospectivos , Derivación y Consulta , Distribución por SexoRESUMEN
To define the pattern of serum and gastric lactic dehydrogenase (LDH) in Nigerians. Levels of this glycolytic enzyme were estimated in 60 (49M, 20F) healthy Nigerians using the spectrophotometric techniques. The mean serum LDH levels were 181.2 +/- 43.9 i.u./L and 157.05 +/- 37.82 i.u./L in males and females respectively. The difference related to sex was significant (P greater than 0.05). The mean gastric juice LDH levels in males and females were 17.39 +/- 7.94 i.u./L and 15.75 +/- 7.50 i.u./L. There was no correlation between the serum and gastric juice LDH levels. The levels in the healthy Nigerians are comparable to the observed values in the caucasians.
Asunto(s)
Jugo Gástrico/enzimología , L-Lactato Deshidrogenasa/análisis , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Nigeria , Valores de ReferenciaRESUMEN
LDH is found in many body fluids and tissues. Its level is elevated in many diseases. Thus the levels of LDH in serum and gastric juice were determined in both benign and malignant disease of the upper gastro-intestinal tract using the spectrophotometric techniques. 45 patients were included in the study (duodenal ulcer 19; gastric ulcer 6; gastric polyps 5; and gastric carcinoma 15). Serum LDH levels were not significantly elevated. However, the gastric juice LDH levels were significantly elevated in gastric polyps and gastric carcinoma. The mean levels were 96.81 +/- 14.31 and 443.2 +/- 58.1 i.u./L respectively. Serial estimation of gastric juice LDH in patients with gastric polyps showed a remarkable elevation at the time of malignant transformation.