Association between ultra-processed foods and recurrence of depressive symptoms: the Whitehall II cohort study.

OBJECTIVES: To examine the association between high intakes of ultra-processed foods (UPF) and recurrence of depressive symptoms (DepS) in a Western non-Mediterranean country and its contribution to the overall diet-depression relationship. METHODS: Analyses were carried out on British participants from the Whitehall II cohort. Present analyses were restricted to white participants N = 4554 (74% men, mean age = 61; SD = 5.9). UPF consumption was estimated from a 127-item food frequency questionnaire using the NOVA classification, and cumulative average of UPF intakes (g/day) over 11 years of exposure (1991/1994-2002/2004) was computed. Recurrent DepS after measurement of UPF was defined as having two or more episodes of DepS (the Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16 or antidepressants use) during four phases of follow-up (2002/2004-2015/2016). RESULTS: Over the follow-up, 588 (12.9%) cases of recurrent DepS were observed. After adjusting for socio-demographic factors, health behaviours and health status, participants in top quintile of UPF intakes [mean 33% of total daily intakes in grams] had 31% higher odds of recurrent DepS (odds ratio 1.31; 95% CI 1.04-1.64) compared to participants in the four lowest quintiles of UPF [mean 18.1% of total daily intakes in grams]. Additional analyses showed that associations between adherence to several diet quality measures and recurrent DepS were partially attenuated (17-27%) by UPF intakes. CONCLUSION: In this British population, high intakes of ultra-processed foods were associated with increased odds of recurrent depressive symptoms and contributed to the overall diet quality-depressive symptoms association.

A Multi-Sensing IoT System for MiC Module Monitoring during Logistics and Operation Phases.

Modular integrated construction (MiC) is now widely adopted by industry and governments. However, its fragile and delicate logistics are still a concern for impeding project performance. MiC logistic operations involve rigorous multimode transportation, loading-unloading, and stacking during storage. Such processes may induce latent and intrinsic damage to the module. This damage causes safety hazards during assembly and deteriorates the module's structural health during the building use phase. Also, additional inspection and repairs before assembly cause uncertainties and can delay the whole supply chain. Therefore, continuous monitoring of the module's structural response during MiC logistics and the building use phase is vital. An IoT-based multi-sensing system is developed, integrating an accelerometer, gyroscope, and strain sensors to measure the module's structural response. The compact, portable, wireless sensing devices are designed to be easily installed on modules during the logistics and building use phases. The system is tested and calibrated to ensure its accuracy and efficiency. Then, a detailed field experiment is demonstrated to assess the damage, safety, and structural health during MiC logistic operations. The demonstrated damage assessment methods highlight the application for decision-makers to identify the module's structural condition before it arrives on site and proactively avoid any supply chain disruption. The developed sensing system is directly helpful for the industry in monitoring MiC logistics and module structural health during the use phase. The system enables the researchers to investigate and improve logistic strategies and module design by accessing detailed insights into the dynamics of MiC logistic operations.

Diet and depression: exploring the biological mechanisms of action.

The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.