RESUMEN
AIM: In animal studies, aminoglycosides induced ductus arteriosus relaxation in a dose-dependent fashion. We tested the hypothesis that antibiotic treatment of preterm infants with aminoglycosides is associated with higher rates of surgical patent ductus arteriosus (PDA) closure. METHODS: Preterm infants (birthweight <1000 grams or gestational age <29 weeks) enrolled in 62 German neonatal intensive care units (NICUs) were analysed. NICUs were stratified according to the use of aminoglycosides as first-line antibiotics. RESULTS: Baseline data were not different when NICUs using aminoglycosides (n = 9965 infants) were compared to NICUs using other antibiotics (n = 1948 infants). Rates of surgical PDA closure were 5.9% for NICUs using aminoglycosides; 6.2% for units using gentamicin; and 5.0% for NICUs using tobramycin compared to 4.1% in NICUs using other antibiotics (P < .001, P < .001 and P = .140, respectively, Fisher's exact test). Indomethacin and ibuprofen use was more common in NICUs using aminoglycosides (41% vs 33%, P < .001, Fisher's exact test). Gentamicin trough levels were higher in NICUs with surgical closure rates above the mean (median 2.0 µg/mL, inter-quartile range 0.8-4.0 µg/mL vs 1.2 µg/mL, IQR 0.8-1.7, P < .001, Mann-Whitney U test). CONCLUSION: First-line antibiotic treatment of preterm infants with aminoglycosides was associated with higher rates of surgical PDA closure.
Asunto(s)
Conducto Arterioso Permeable , Aminoglicósidos , Antibacterianos , Conducto Arterioso Permeable/tratamiento farmacológico , Conducto Arterioso Permeable/cirugía , Humanos , Ibuprofeno , Indometacina , Lactante , Recién Nacido , Recien Nacido PrematuroRESUMEN
We report a case of an extremely low birth weight premature infant born at 27 weeks of gestation, transferred to our tertiary pediatric referral center for surgical repair of an esophageal atresia. Endoscopic evaluation before the start of surgery revealed a hypopharyngeal perforation, resulting in the false impression of esophageal atresia. If no tracheoesophageal fistula is found during tracheoscopy, esophagoscopy should be done before surgical intervention as the inability to pass a nasogastric tube into the stomach is not sufficiently reliable for a correct diagnosis of esophageal atresia.
Asunto(s)
Atresia Esofágica , Fístula Traqueoesofágica , Niño , Atresia Esofágica/diagnóstico , Atresia Esofágica/cirugía , Esofagoscopía , Humanos , Lactante , Recien Nacido con Peso al Nacer Extremadamente Bajo , Recién Nacido , Intubación Gastrointestinal , Fístula Traqueoesofágica/diagnóstico por imagen , Fístula Traqueoesofágica/cirugíaRESUMEN
OBJECTIVE: To determine if survival rates of preterm infants receiving active perinatal care improve over time. DESIGN: The German Neonatal Network is a cohort study of preterm infants with birth weight <1500 g. All eligible infants receiving active perinatal care are registered. We analysed data of patients discharged between 2011 and 2016. SETTING: 43 German level III neonatal intensive care units (NICUs). PATIENTS: 8222 preterm infants with a gestational age between 22/0 and 28/6 weeks who received active perinatal care. INTERVENTIONS: Participating NICUs were grouped according to their specific survival rate from 2011 to 2013 to high (percentile >P75), intermediate (P25-P75) and low (Asunto(s)
Recien Nacido Extremadamente Prematuro
, Unidades de Cuidado Intensivo Neonatal/estadística & datos numéricos
, Atención Perinatal/métodos
, Atención Perinatal/estadística & datos numéricos
, Mortalidad Perinatal/tendencias
, Causas de Muerte
, Comorbilidad
, Femenino
, Edad Gestacional
, Estado de Salud
, Humanos
, Lactante
, Recién Nacido
, Recién Nacido de muy Bajo Peso
, Masculino
, Estudios Prospectivos
, Mejoramiento de la Calidad
, Factores de Riesgo
, Factores Sexuales
, Centros de Atención Terciaria